The prognostic significance of 8p21 deletion in multiple myeloma

British Journal of Haematology

Volumn 144, Issue 2, 2009, Pages 266-268

  Sutlu, T ^a   Alici, E ^a   Jansson, M ^a   Wallblom, A ^a   Dilber, M S ^a   Gahrton, G ^a   Nahi, H ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

8p21; Autologous haematopoietic stem cell transplantation; Fluorescent in situ hybridization; Multiple myeloma; Survival analysis

Indexed keywords

BONE MARROW BIOPSY; CHROMOSOME; CHROMOSOME 8P21; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; HUMAN; LETTER; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROGNOSIS;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 8; GENE DELETION; HUMANS; MULTIPLE MYELOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS;

EID: 58149095084     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07454.x     Document Type: Letter

References (8)

1. Avet-Loiseau, H., Attal, M., Moreau, P., Charbonnel, C., Garban, F., Hulin, C., Leyvraz, S., Michallet, M., Yakoub-Agha, I., Garderet, L., Marit, G., Michaux, L., Voillat, L., Renaud, M., Grosbois, B., Guillerm, G., Benboubker, L., Monconduit, M., Thieblemont, C., Casassus, P., Caillot, D., Stoppa, A.M., Sotto, J.J., Wetterwald, M., Dumontet, C., Fuzibet, J.G., Azais, I., Dorvaux, V., Zandecki, M., Bataille, R., Minvielle, S., Harousseau, J.L., Facon, T. Mathiot, C. (2007) Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome. Blood, 109, 3489 3495.
2. Chng, W.J. Fonseca, R. (2005) Risk stratification of patients with newly diagnosed multiple myeloma: optimizing treatment based on pretreatment characteristics. Clinical Lymphoma & Myeloma, 6, 200 207.
3. Durie, B.G., Kyle, R.A., Belch, A., Bensinger, W., Blade, J., Boccadoro, M., Child, J.A., Comenzo, R., Djulbegovic, B., Fantl, D., Gahrton, G., Harousseau, J.L., Hungria, V., Joshua, D., Ludwig, H., Mehta, J., Morales, A.R., Morgan, G., Nouel, A., Oken, M., Powles, R., Roodman, D., San Miguel, J., Shimizu, K., Singhal, S., Sirohi, B., Sonneveld, P., Tricot, G. Van Ness, B. (2003) Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation. The Hematology Journal, 4, 379 398.
4. Gazitt, Y. (1999) TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia, 13, 1817 1824.
5. Hornstein, M., Hoffmann, M.J., Alexa, A., Yamanaka, M., Muller, M., Jung, V., Rahnenfuhrer, J. Schulz, W.A. (2008) Protein Phosphatase and TRAIL Receptor Genes as New Candidate Tumor Genes on Chromosome 8p in Prostate Cancer. Cancer Genomics Proteomics, 5, 123 136.
6. Martinez-Climent, J.A., Vizcarra, E., Sanchez, D., Blesa, D., Marugan, I., Benet, I., Sole, F., Rubio-Moscardo, F., Terol, M.J., Climent, J., Sarsotti, E., Tormo, M., Andreu, E., Salido, M., Ruiz, M.A., Prosper, F., Siebert, R., Dyer, M.J. Garcia-Conde, J. (2001) Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma. Blood, 98, 3479 3482.
7. Rubio-Moscardo, F., Blesa, D., Mestre, C., Siebert, R., Balasas, T., Benito, A., Rosenwald, A., Climent, J., Martinez, J.I., Schilhabel, M., Karran, E.L., Gesk, S., Esteller, M., deLeeuw, R., Staudt, L.M., Fernandez-Luna, J.L., Pinkel, D., Dyer, M.J. Martinez-Climent, J.A. (2005) Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood, 106, 3214 3222.
8. Takeda, K., Smyth, M.J., Cretney, E., Hayakawa, Y., Kayagaki, N., Yagita, H. Okumura, K. (2002) Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. Journal of Experimental Medicine, 195, 161 169.