Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors

Journal of Medicinal Chemistry

Volumn 51, Issue 24, 2008, Pages 7670-7672

  Gopalsamy, Ariamala ^a   Shi, Mengxiao ^a   Stauffer, Barbara ^b   Bahat, Ramesh ^b   Billiard, Julia ^b   Ponce De Leon, Helga ^b   Seestaller Wehr, Laura ^b   Fukayama, Shoichi ^b   Mangine, Annamarie ^b   Moran, Robert ^b   Krishnamurthy, Girija ^a   Bodine, Peter ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYLSULFONE SULFONAMIDE; PROTEIN INHIBITOR; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 1 INHIBITOR; SULFONAMIDE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE STRENGTH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STABILITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR SIZE; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN FUNCTION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOCHEMISTRY; BONE DENSITY; CELLS, CULTURED; DRUG DESIGN; HUMANS; MICE; MODELS, CHEMICAL; OSTEOBLASTS; PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES;

EID: 58149092256     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801069w     Document Type: Article

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