Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa

Child and Adolescent Psychiatry and Mental Health

Volumn 2, Issue , 2008, Pages

  Müller, Timo Dirk ^a,i   Reichwald, Kathrin ^a,b   Brönner, Günter ^a,c   Kirschner, Jeanette ^b   Nguyen, Thuy Trang ^d   Scherag, André ^a,d   Herzog, Wolfgang ^e   Herpertz Dahlmann, Beate ^f   Lichtner, Peter ^g,h   Meitinger, Thomas ^g,h   Platzer, Matthias ^b   Schäfer, Helmut ^d   Hebebrand, Johannes ^a   Hinney, Anke ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL LIPASE; ADENOSINE; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; FATTY ACID AMIDASE; HYDROLASE; N ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE; THYMIDINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; ARTICLE; BODY WEIGHT; CASE CONTROL STUDY; CONTROLLED STUDY; DNA FLANKING REGION; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 58049150199     PISSN: None     EISSN: 17532000     Source Type: Journal    
DOI: 10.1186/1753-2000-2-33     Document Type: Article

References (56)

1. Hinney A Friedel S Remschmidt H Hebebrand J Genetic risk factors in eating disorders Am J Pharmacogenomics 2004, 4:209-223. 10.2165/ 00129785-200404040-00001 15287815
2. Monteleone P Matias I Martiadis V De Petrocellis L Maj M Di Marzo V Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa Neuropsychopharmacology 2005, 30:1216-1221. 10.1038/sj.npp.1300695 15841111
3. Bulik CM Hebebrand J Keski-Rahkonen A Klump KL Reichborn-Kjennerud T Mazzeo SE Wade TD Genetic epidemiology, endophenotypes, and eating disorder classification Int J Eat Disord 2007, 40(Suppl):S52-60. 10.1002/ eat.20398 17573683
4. Klump KL Miller KB Keel PK McGue M Iacono WG Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample Psychol Med 2001, 31:737-740. 10.1017/S0033291701003725 11352375
5. Hebebrand J Muller TD Holtkamp K Herpertz-Dahlmann B The role of leptin in anorexia nervosa: Clinical implications Mol Psychiatry 2007, 12:23-35. 10.1038/sj.mp.4001909 17060920
6. Halmi KA Eating disorders in females: Genetics, pathophysiology, and treatment J Pediatr Endocrinol Metab 2002, 15(Suppl 5):1379-1386. 12510994
7. Støving RK Andries A Brixen K Flyvbjerg A Hørder K Frystyk J Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa J Psychiatr Res 2008.
8. Di Marzo V Bifulco M De Petrocellis L The endocannabinoid system and its therapeutic exploitation Nat Rev Drug Discov 2004, 3:771-784. 10.1038/ nrd1495 15340387
9. Colombo G Agabio R Diaz G Lobina C Reali R Gessa GL Appetite suppression and weight loss after the cannabinoid antagonist SR 141716 Life Sci 1998, 63:PL113-117. 10.1016/S0024-3205(98)00322-1 9718088
10. Liu YL Connoley IP Wilson CA Stock MJ Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice Int J Obes (Lond) 2005, 29:183-187. 10.1038/sj.ijo.0802847 15558076
11. Di Marzo V Goparaju SK Wang L Liu J Bátkai S Járai Z Fezza F Miura GI Palmiter RD Sugiura T Kunos G Leptin-regulated endocannabinoids are involved in maintaining food intake Nature 2001, 410:822-825. 10.1038/35071088 11298451
12. van Gaal LF Rissanen AM Scheen AJ Ziegler O Rössner S RIO-Europe Study Group Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study Lancet 2005, 365:1389-1397. 10.1016/S0140-6736(05)66374-X 15836887
13. Després JP Golay A Sjöström L Rimonabant in Obesity-Lipids Study Group Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia N Engl J Med 2005, 353:2121-2134. 10.1056/NEJMoa044537 16291982
14. Hebebrand J Exner C Hebebrand K Holtkamp C Casper RC Remschmidt H Herpertz-Dahlmann B Klingenspor M Hyperactivity in patients with anorexia nervosa and in semistarved rats: Evidence for a pivotal role of hypoleptinemia Physiol Behav 2003, 79:25-37. 10.1016/ S0031-9384(03)00102-1 12818707
15. Exner C Hebebrand J Remschmidt H Wewetzer C Ziegler A Herpertz S Schweiger U Blum WF Preibisch G Heldmaier G Klingenspor M Leptin suppresses semi-starvation induced hyperactivity in rats: Implications for anorexia nervosa Mol Psychiatry 2000, 5:476-481. 10.1038/ sj.mp.4000771 11032380
16. Holtkamp K Herpertz-Dahlmann B Mika C Heer M Heussen N Fichter M Herpertz S Senf W Blum WF Schweiger U Warnke A Ballauff A Remschmidt H Hebebrand J Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa J Clin Endocrinol Metab 2003, 88:5169-5174. 10.1210/jc.2003-030569 14602745
17. Holtkamp K Hebebrand J Herpertz-Dahlmann B The contribution of anxiety and food restriction on physical activity levels in acute anorexia nervosa Int J Eat Disord 2004, 36:163-171. 10.1002/eat.20035 15282686
18. Holtkamp K Herpertz-Dahlmann B Hebebrand K Mika C Kratzsch J Hebebrand J Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa Biol Psychiatry 2006, 60:311-313. 10.1016/j.biopsych.2005.11.001 16376860
19. Devane WA Hanus L Breuer A Pertwee RG Stevenson LA Griffin G Gibson D Mandelbaum A Etinger A Mechoulam R Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 1992, 258:1946-1949. 10.1126/science.1470919 1470919
20. Sugiura T Kondo S Sukagawa A Nakane S Shinoda A Itoh K Yamashita A Waku K 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain Biochem Biophys Res Commun 1995, 215:89-97. 10.1006/ bbrc.1995.2437 7575630
21. Di Marzo V Biosynthesis and inactivation of endocannabinoids: Relevance to their proposed role as neuromodulators Life Sci 1999, 65:645-655. 10.1016/S0024-3205(99)00287-8 10462065
22. Dinh TP Freund TF Piomelli D A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation Chem Phys Lipids 2002, 121:149-158. 10.1016/S0009-3084(02)00150-0 12505697
23. Puffenbarger RA Molecular biology of the enzymes that degrade endocannabinoids Curr Drug Targets CNS Neurol Disord 2005, 4:625-631. 10.2174/156800705774933050 16375680
24. Hillard CJ Wilkison DM Edgemond WS Campbell WB Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain Biochim Biophys Acta 1995, 1257(3):249-256. 7647100
25. Cravatt BF Giang DK Mayfield SP Boger DL Lerner RA Gilula NB Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Nature 1996, 384:83-87. 10.1038/384083a0 8900284
26. Cravatt BF Demarest K Patricelli MP Bracey MH Giang DK Martin BR Lichtman AH Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Proc Natl Acad Sci USA 2001, 98:9371-9376. 55427 11470906 10.1073/ pnas.161191698
27. Tsuboi K Sun YX Okamoto Y Araki N Tonai T Ueda N Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase J Biol Chem 2005, 280:11082-11092. 10.1074/jbc.M413473200 15655246
28. Tsuboi K Takezaki N Ueda N The N-acylethanolamine-hydrolyzing acid amidase (NAAA) Chem Biodivers 2007, 4:1914-1925. 10.1002/cbdv.200790159 17712833
29. Siegfried Z Kanyas K Latzer Y Karni O Bloch M Lerer B Berry EM Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and binging/purging subtypes Am J Med Genet B Neuropsychiatr Genet 2004, 125B:126-130. 10.1002/ajmg.b.20089 14755457
30. Sipe JC Waalen J Gerber A Beutler E Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH) Int J Obes (Lond) 2005, 29:755-759. 10.1038/sj.ijo.0802954 15809662
31. Sipe JC Chiang K Gerber AL Beutler E Cravatt BF A missense mutation in human fatty acid amide hydrolase associated with problem drug use Proc Natl Acad Sci USA 2002, 99:8394-8399. 123078 12060782 10.1073/ pnas.082235799
32. Zhang PW Ishiguro H Ohtsuki T Hess J Carillo F Walther D Onaivi ES Arinami T Uhl GR Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse Mol Psychiatry 2004, 9:916-931. 10.1038/ sj.mp.4001560 15289816
33. Hinney A Lentes KU Rosenkranz K Barth N Roth H Ziegler A Hennighausen K Coners H Wurmser H Jacob K Römer G Winnikes U Mayer H Herzog W Lehmkuhl G Poustka F Schmidt MH Blum WF Pirke KM Schäfer H Grzeschik KH Remschmidt H Hebebrand J Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa Int J Obes Relat Metab Disord 1997, 21:224-230. 10.1038/sj.ijo.0800391 9080262
34. American Psychiatric Association Diagnostic and statistical manual of mental disorders (DSM-IV) Washington, DC 1994, 539-549.
35. Müller TD Reichwald K Wermter AK Brönner G Nguyen TT Friedel S Koberwitz K Engeli S Lichtner P Meitinger T Schäfer H Hebebrand J Hinney A No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents Mol Genet Metab 2007, 90:429-434. 10.1016/j.ymgme.2007.01.002 17292652
36. Spielman RS McGinnis RE Ewens WJ Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 1993, 52:506-516. 1682161 8447318
37. Comings DE Muhleman D Gade R Johnson P Verde R Saucier G MacMurray J Cannabinoid receptor gene (CNR1): Association with i.v. drug use Mol Psychiatry 1997, 2:161-168. 10.1038/sj.mp.4000247 9106242
38. Covault J Gelernter J Kranzler H Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence Mol Psychiatry 2001, 6:501-502. 10.1038/sj.mp.4000925 11526463
39. Gazzerro P Caruso MG Notarnicola M Misciagna G Guerra V Laezza C Bifulco M Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population Int J Obes (Lond) 2007, 31:908-912. 10.1038/sj.ijo.0803510 17160086
40. Peeters A Beckers S Mertens I van Hul W van Gaal L The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men Endocrine 2007, 31:138-141. 10.1007/ s12020-007-0022-y 17873324
41. Benzinou M Chèvre JC Ward KJ Lecoeur C Dina C Lobbens S Durand E Delplanque J Horber FF Heude B Balkau B Borch-Johnsen K Jørgensen T Hansen T Pedersen O Meyre D Froguel P Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations Hum Mol Genet 2008, 17:1916-1921. 10.1093/hmg/ ddn089 18375449
42. Pagotto U Marsicano G Cota D Lutz B Pasquali R The emerging role of the endocannabinoid system in endocrine regulation and energy balance Endocr Rev 2006, 27:73-100. 10.1210/er.2005-0009 16306385
43. Poster DS Penta JS Bruno S Macdonald JS Delta 9-tetrahydrocannabinol in clinical oncology JAMA 1981, 245:2047-2051. 10.1001/jama.245.20.2047 6262541
44. Gorter RW Cancer cachexia and cannabinoids Forsch Komplementarmed 1999, 6(Suppl 3):21-22. 10.1159/000057152 10575285
45. Gross H Ebert MH Faden VB Goldberg SC Kaye WH Caine ED Hawks R Zinberg N A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa J Clin Psychopharmacol 1983, 3:165-171. 10.1097/ 00004714-198306000-00004 6308069
46. Naruse T Amano H Koizumi Y Possible involvement of dopamine D-1 and D-2 receptors in diazepam-induced hyperphagia in rats Fundam Clin Pharmacol 1991, 5:677-693. 1838347
47. Naruse T Effects of repeated intravenous administration of diazepam on food intake in rats Fundam Clin Pharmacol 1994, 8:379-384. 7851844
48. Hinney A Bornscheuer A Depenbusch M Mierke B Tölle A Middeke K Ziegler A Roth H Gerber G Zamzow K Ballauff A Hamann A Mayer H Siegfried W Lehmkuhl G Poustka F Schmidt MH Hermann H Herpertz-Dahlmann BM Fichter M Remschmidt H Hebebrand J No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: Identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region Mol Psychiatry 1998, 3:539-543. 10.1038/sj.mp.4000394 9857981
49. Quinton ND Meechan DW Brown K Eastwood H Blakemore AI Single nucleotide polymorphisms in the leptin receptor gene: Studies in anorexia nervosa Psychiatr Genet 2004, 14:191-194. 10.1097/00041444-200412000-00004 15564891
50. Miyasaka K Hosoya H Sekime A Ohta M Amono H Matsushita S Suzuki K Higuchi S Funakoshi A Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population J Neural Transm 2006, 113:1279-1285. 10.1007/s00702-005-0393-2 16362631
51. Monteleone P Tortorella A Castaldo E Di Filippo C Maj M No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa Neurosci Lett 2006, 398:325-327. 10.1016/j.neulet.2006.01.023 16472909
52. Ribasés M Gratacòs M Armengol L de Cid R Badía A Jiménez L Solano R Vallejo J Fernández F Estivill X Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type Mol Psychiatry 2003, 8:745-751. 10.1038/sj.mp.4001281 12888803
53. Ribasés M Gratacòs M Fernández-Aranda F Bellodi L Boni C Anderluh M Cavallini MC Cellini E Di Bella D Erzegovesi S Foulon C Gabrovsek M Gorwood P Hebebrand J Hinney A Holliday J Hu X Karwautz A Kipman A Komel R Nacmias B Remschmidt H Ricca V Sorbi S Wagner G Treasure J Collier DA Estivill X Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations Hum Mol Genet 2004, 13:1205-1212. 10.1093/hmg/ddh137 15115760
54. Ribasés M Gratacòs M Fernández-Aranda F Bellodi L Boni C Anderluh M Cristina Cavallini M Cellini E Di Bella D Erzegovesi S Foulon C Gabrovsek M Gorwood P Hebebrand J Hinney A Holliday J Hu X Karwautz A Kipman A Komel R Nacmias B Remschmidt H Ricca V Sorbi S Tomori M Wagner G Treasure J Collier DA Estivill X Association of BDNF with restricting anorexia nervosa and minimum body mass index: A family-based association study of eight European populations Eur J Hum Genet 2005, 13:428-434. 10.1038/sj.ejhg.5201351 15657604
55. Friedel S Horro FF Wermter AK Geller F Dempfle A Reichwald K Smidt J Brönner G Konrad K Herpertz-Dahlmann B Warnke A Hemminger U Linder M Kiefl H Goldschmidt HP Siegfried W Remschmidt H Hinney A Hebebrand J Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/ hyperactivity disorder Am J Med Genet B Neuropsychiatr Genet 2005, 132B:96-99. 10.1002/ajmg.b.30090 15457498
56. Ando T Ishikawa T Kawamura N Karibe M Oba M Tatsuta N Hara S Takii M Naruo T Takei M Kurokawa N Nozoe S Kubo C Komaki G Analysis of tumor necrosis factor-alpha gene promoter polymorphisms in anorexia nervosa Psychiatr Genet 2001, 11:161-164. 10.1097/00041444-200109000-00009 11702059