Eating disorders in females: Genetics, pathophysiology, and treatment

Journal of Pediatric Endocrinology and Metabolism

Volumn 15, Issue SUPPL. 5, 2002, Pages 1379-1386

  Halmi, Katherine ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Anorexia nervosa; Bulimia nervosa; Genetics; Serotonin; Serotonin reuptake inhibitors

Indexed keywords

ANTIDEPRESSANT AGENT; CHLORPROMAZINE; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; CYPROHEPTADINE; FLUOXETINE; GONADORELIN; LEPTIN; NEUROPEPTIDE; OLANZAPINE; OXYTOCIN; SEROTONIN; VASOPRESSIN;

AFFECTIVE PSYCHOSIS; ANOREXIA NERVOSA; ANXIETY DISORDER; ARTICLE; BEHAVIOR THERAPY; BULIMIA; CLINICAL TRIAL; COGNITIVE THERAPY; COMORBIDITY; EATING HABIT; FAMILY COUNSELING; FAMILY HISTORY; FAMILY LIFE; FEMALE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; NEUROENDOCRINE SYSTEM; PATHOGENESIS; PERSONALITY DISORDER; PSYCHOPHARMACOTHERAPY; SOCIAL INTERACTION; STARVATION; SUBSTANCE ABUSE; SYMPTOMATOLOGY; TREATMENT PLANNING;

ANOREXIA NERVOSA; BULIMIA; CHOLECYSTOKININ; DOPAMINE; FEMALE; HUMANS; NEUROPEPTIDE Y; SEROTONIN;

EID: 0036916591     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bell RM. Holy Anorexia. Chicago, IL: University of Chicago Press, 1985.
2. Halmi KA. Eating disorders. In: Hales KE, Yudofsky SC, Talbott J, eds. American Psychiatric Press Textbook of Psychiatry, 3rd Ed. Washington, DC: American Psychiatric Association Press Inc., 1999; 983-1002.
3. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Washington, DC: American Psychiatric Association, 1994.
4. Halmi KA, Falk JR. Common physiological changes in anorexia nervosa. Int J Eat Disord 1981; 1: 16-27.
5. Braun DL, Sunday SR, Halmi KA. Psychiatric comorbidity in patients with eating disorders. Psychol Med 1994; 24: 859-867.
6. Eckert ED, Halmi KA, Marchi P, Grove W, Crosby R. Ten-year follow-up of anorexia nervosa: clinical course and outcome. Psychol Med 1995; 25: 143-156.
7. Theander S. Outcome and prognosis in anorexia nervosa and bulimia: some results of previous investigations, compared with those of a Swedish long-term study. J Psychiatr Res 1985; 19: 493-508.
8. Keel PK, Mitchell JE. Outcome in bulimia nervosa. Am J Psychiatry 1997; 154: 313-321.
9. Zipfel S, Seibel MJ, Lowe B, Beumont PJ, Kasperk C, Herzog W. Osteoporosis in eating disorders: a follow up study of patients with anorexia and bulimia nervosa. J Clin Endocrinol Metab 2001; 86: 5227-5233.
10. Strober M, Morell W, Burroughs J. A controlled family study of anorexia nervosa. Psychiatr Res 1985; 19: 329-346.
11. Lilenfeld LR, Kaye WH, Greeno CG, Merikangas KR, Plotnicov K, Pollice C, Rao R, Strober M, Bulik CM, Nagy L. A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. Arch Gen Psychiatry 1998; 55: 603-610.
12. Kendler KS, MacLean C, Neale M, Kessler R, Heath A, Eaves L. The genetic epidemiology of bulimia nervosa. Am J Psychiatry 1991; 148: 1627-1637.
13. Walters EE, Kendler KS. Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample. Am J Psychiatry 1995; 152: 64-71.
14. Lilenfeld LR, Kaye WH, Greeno CG, Merikangas KR, Plotnicov K, Pollice C, Rao R, Strober M, Bulik CM, Nagy L. Psychiatric disorders in women with bulimia nervosa and their first degree relatives: effects of comorbid substance dependence. Int J Eat Disord 1997; 22: 253-264.
15. Grice DE, Halmi KA, Fichter MM, Strober M, Woodside DB, Treasure JT, Kaplan AS, Magistretti PJ, Goldman D, Bulik CM, Kaye WH, Berrettini WH. Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. Am J Hum Genet 2002; 70: 787-792.
16. Halmi KA, Sunday SR, Strober M, Kaplan A, Woodside DB, Fichter M, Berrettini WH, Kaye WH. Perfectionism in anorexia nervosa: variation by clinical subtype, obsessionality, and pathological eating behavior. Am J Psychiatry 2000; 157: 1799-1805.
17. Devlin B, Bacanu S, Klump K, Bulik C, Fichter M, Halmi KA, Kaplan A, Strober M, Woodside B, Berrettini W, Kaye WH. Linkage analysis of anorexia nervosa incorporating behavioral covariates. Hum Mol Genet; in press.
18. Hotta M, Shibasaki T, Massuda A, Imaki T, Deumura H, Ling N, Shizume K. The responses of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. J Clin Endocrinol Metab 1986; 62: 319-324.
19. Gold PW, Gwirtsman H, Kaye W. Pathophysiologic mechanisms in underweight and weight corrected patients. N Engl J Med 1986; 314: 335-342.
20. Halmi KA. Basic biological overview of eating disorders. In: Bloom FE, Kupfur DJ, eds. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, 1995; 1609-1616.
21. Falk JR, Halmi KA. Amenorrhea in anorexia nervosa: examination of the critical body hypothesis. Biol Psychiatry 1982; 17: 799-806.
22. Morley JE, Levine AS. The pharmacology of eating behavior. Annu Rev Pharmacol Toxicol 1985; 25: 127-146.
23. Kaye WH, Berrettini W, Gwirtsman H, George DT. Altered cerebral spinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa. Arch Gen Psychiatry 1990; 47: 548-556.
24. Morley JE, Levine AS, Grace M, Kneip J. Peptide YY (PYY), a potent orexigenic agent. Brain Res 1985; 341: 200-203.
25. Bohus B, Kovacs GL, de Wied D. Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes. Brain Res 1978; 157: 414-417.
26. Demitrek M, Kalogeras K, Altemus M. Plasma and cerebral spinal fluid measures of arginine vasopressin secretion in patients with bulimia nervosa and in healthy subjects. J Clin Endocrinol Metab 1992; 4: 1277-1283.
27. Tamai H, Takemura J, Kobayashi M, Matsubayashi S, Matsukura S, Nakagawa T. Changes in plasma cholecystokinin concentrations after oral glucose tolerance test in anorexia nervosa before and after therapy. Metabolism 1993; 42: 581-584.
28. Considine RV, Sinha M, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
29. Eckert ED, Pomeroy C, Raymond N, Kohler PF, Thuras P, Bowers CY. Leptin in anorexia nervosa. J Clin Endocrinol Metab 1998; 83: 791-795.
30. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-252.
31. Hoebel BG. Pharmacologic control of feeding. Annu Rev Pharmacol Toxicol 1977; 17: 605-621.
32. Leibowitz SF. Neurochemical systems of the hypothalamus: control of feeding and drinking behavior. In: Morgan PJ, Panksepp J, eds. Handbook of the Hypothalamus. New York: Raven Press, 1980; 299-347.
33. Soubrie P. Reconciling the role of central serotonin neurosis in human and animal behavior. Behav Brain Sci 1986; 9: 319-363.
34. Barr LC, Goodman WK, Price LH, McDougle CJ, Charney DS. The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacological challenge studies. J Clin Psychiatry 1992; 53: 17-28.
35. Charney DS, Wood SW, Krystal JH, Heninger GR. Serotonin function and human anxiety disorders. Ann NY Acad Sci 1990; 600: 558-572; discussion 572-573.
36. Grahame-Smith DG. Serotonin in affective disorders. Int J Clin Psychopharmacol 1992; 6: 485-513.
37. Kaye WH, Ebert MH, Gwirtsman HE, Weiss SR. Differences in brain serotonergic metabolism between nonbulimic and bulimic patients with anorexia nervosa. Am J Psychiatry 1984; 141: 1598-1601.
38. Jimerson DC, Wolfe BE, Metzger ED, Finkelstein DM, Cooper TB, Levine JM. Decreased serotonin function in bulimia nervosa. Arch Gen Psychiatry 1997; 54: 529-534.
39. 2A receptors: a review of in vivo studies. Behav Brain Res 1996; 73: 177-181.
40. Kaye W, Strober M. The neurobiology of eating disorder. In: Charney DS, Nestler EJ, Bunney BS, eds. Neurobiological Foundations of Mental Illness. New York: Oxford University Press, 1999; 891-906.
41. Liebowitz SF. Brain monoamines and peptides: role in the control of eating behavior. Fed Proc 1986; 45: 1396-1403.
42. Owen WP, Halmi KA, Lesley E. Dopamine regulation in anorexia nervosa. Psychopharmacol Bull 1983; 19: 578-580.
43. Brambilla F, Bellodi L, Arancio C, Ronchi P, Limonta D. Central dopaminergic function in anorexia and bulimia nervosa: a psychoneuroendocrine approach. Psychoneuroendocrinology 2001; 26: 393-409.
44. Levitan RD, Kaplan AS, Joffe RT, Levitt AJ, Brown GM. Hormonal and subjective responses to intravenous meta-chlorophenylpiperazine in bulimia nervosa. Arch Gen Psychiatry 1997; 54: 521-527.
45. Mitchell JE, de Zwaan M. Pharmacological treatments of binge eating. In: Fairburn CG, Wilson T, eds. Binge Eating: Nature, Assessment, and Treatment. New York: Guilford Press, 1993; 120-130.
46. Fairburn CG, Wilson GT. Cognitive-behavioral therapy for binge eating and bulimia nervosa: a comprehensive treatment manual. In: Fairburn CG, Wilson GT, eds. Binge Eating: Nature, Assessment, and Treatment. New York: Guilford Press, 1993; 361-404.
47. Kleifield EI, Wagner S, Halmi KA. Cognitive-behavioral treatment of anorexia nervosa. Psychiatr Clin N Am 1996; 19: 715-737.
48. Mitchell JE, Raymond NC. Cognitive-behavioral therapy and the treatment of bulimia nervosa. In: Halmi KA, ed. The Psychobiology and Treatment of Anorexia. Washington, DC: American Psychiatric Press Inc., 1992; 307-328
49. Halmi KA. Anorexia nervosa and bulimia nervosa. In: Lewis M, ed. Child and Adolescent Psychiatry, 3rd Ed. New York: Lippincott Williams & Wilkins, 2002; 692-700.