Antimycobacterial activity of novel N-(substituted)-2-isonicotinoylhydrazinocarbothioamide endowed with high activity towards isoniazid resistant tuberculosis

Biomedicine and Pharmacotherapy

Volumn 63, Issue 1, 2009, Pages 36-39

  Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Yelamanchili Priya, Darshini ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antimycobacterial activity; Isoniazid; Tuberculosis

Indexed keywords

2 ISONICOTINOYL N [2 (TRIFLUOROMETHYL)PHENYL]HYDRAZINECARBOTHIOAMIDE; ANTIMYCOBACTERIAL AGENT; ISONIAZID; ISONIAZID DERIVATIVE; PHENYL THIOCARBAMATE; POTASSIUM SALT; UNCLASSIFIED DRUG;

AGAR DILUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, BACTERIAL; FEMALE; ISONIAZID; MICE; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; SEMICARBAZIDES; TUBERCULOSIS; VERO CELLS;

EID: 58049140164     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2008.01.012     Document Type: Article

References (11)

1. (May 2006). http://www.who.int/mediacentre/events/2006/world.tb.day/en/index.html
2. Mandell G.L., and Sande M.A. Antimicrobial agents: drugs used in the chemotherapy of tuberculosis and leprosy. In: Gilman A.G., Goodman L.S., Rall T.W., Vies A.S., and Taylor P. (Eds). The pharmacological basis of therapeutics. 8th ed. (1990), Pergamon Press, New York 1146-1153
3. Blair I.A., Timoco R.M., Brodie M.J., Clarc R.A., Dollery T., Timbrell J.A., et al. Plasma hydrazine concentrations in man after isoniazid and hydralazine administration. Hum Toxicol 4 (1985) 195-202
4. Sbarbaro J.A. Multidrug-resistant tuberculosis. It is time to focus on the private sector of medicine. Chest 111 (1997) 1149-1151
5. Sriram D., Yogeeswari P., and Madhu K. Synthesis and in vitro and in vivo antimycobacterial activity of isonicotinoyl hydrazones. Bioorg Med Chem Lett 15 (2005) 4502-4505
6. Sriram D., Yogeeswari P., and Madhu K. Synthesis and in vitro antitubercular activity of some 1-[(4-sub)phenyl]-3-(4-{1-[(pyridine-4-carbonyl)hydrazono]ethyl}phenyl)thiourea. Bioorg Med Chem Lett 16 (2006) 876-878
7. Shaharyar M., Siddiqui A.A., Ali M.A., Sriram D., and Yogeeswari P. Synthesis and in vitro antimycobacterial activity of N1-nicotinoyl-3-(4′-hydroxy-3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines. Bioorg Med Chem Lett 16 (2006) 3947-3949
8. National Committee for Clinical Laboratory Standards. Antimycobacterial susceptibility testing for Mycobacterium tuberculosis. Proposed standard M24-T (1995), National Committee for Clinical Laboratory Standards, Villanova, PA
9. Sriram D., Yogeeswari P., and Devakaram R.V. Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides. Bioorg Med Chem 14 (2006) 3113-3118
10. Kirk R.E. Experimental design procedures for the behavioral sciences (1986), Brooks-Cole, Belmont, CA
11. Bundgaard H., and Moss J. Prodrugs of peptides. 6. Bioreversible derivatives of thyrotropin-releasing hormone (TRH) with increased lipophilicity and resistance to cleavage by the TRH-specific serum enzyme. Pharm Res 7 (1990) 885-892