Interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum in vitro

Wiener Klinische Wochenschrift

Volumn 120, Issue SUPPL. 4, 2008, Pages 85-89

  Starzengruber, Peter ^a   Kollaritsch, Herwig ^a   Sirichaisinthop, Jeeraphat ^b   Wernsdorfer, Gunther ^c   Congpuong, Kanungnit ^b   Wernsdorfer, Walther H ^a,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MINISTRY OF PUBLIC HEALTH   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Lumefantrine; Monodesbutyl benflumetol; Plasmodium falciparum; Synergism

Indexed keywords

BENFLUMETOL; CHLOROQUINE; FLUORENE DERIVATIVE; MONODESBUTYLBENFLUMETOL; PRIMAQUINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GROWTH INHIBITION; HUMAN; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; PHARMACODYNAMICS; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX MALARIA; SCHIZONT; SCHOOL CHILD; SINGLE DRUG DOSE;

ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ETHANOLAMINES; FLUORENES; MYANMAR; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; THAILAND;

EID: 57849106490     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-008-1080-8     Document Type: Article

References (13)

1. World Health Organization (1990) Practical chemotherapy of malaria. Report of a WHO Scientific Group. WHO Tech Rep Ser 805, WHO, Geneva, pp 124-126
2. S Yeung W Pongtavompinyo IM Hastings AJ Mills NJ White 2004 Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modelling to elucidating policy choices Am J Trop Med Hyg 71 Suppl 2 179 186
3. H Noedl T Allmendinger S Prajakwong G Wernsdorfer WH Wernsdorfer 2001 Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand Antimicrob Agents Chemother 45 2106 2109
4. P Starzengruber G Wernsdorfer M Parizek C Rojanawatsirivet H Kollaritsch WH Wernsdorfer 2007 Specific pharmacokinetic interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum Wien Klin Wochenschr 119 Suppl 3 60 66
5. DK Pirker-Krassnig G Wernsdorfer J Sirichaisinthop C Rojanawatsirivet H Kollaritsch WH Wernsdorfer 2004 Comparative study on the in vitro activity of lumefantrine and debutyl-benflumetol in fresh isolates of Plasmodium vivax from Thailand Wien Klin Wochenschr 116 Suppl 4 47 52
6. World Health Organization (1991) Basic malaria microscopy. Part I. WHO, Geneva, pp 67-68
7. JT Litchfield Jr F Wilcoxon 1949 A simplified method for evaluating dose-effect experiments J Pharm Exp Ther 96 99 113
8. WH Wernsdorfer MG Wernsdorfer 1995 The evaluation of in vitro tests for the assessment of drug response in Plasmodium falciparum Mitteilungen Oesterr Gesellsch Tropenmed Parasitol 17 221 228
9. MC Berenbaum 1978 A method for testing for synergy with any number of agents J Infect Dis 137 122 130
10. G Lefèvre MS Thomsen 1999 Clinical pharmacokinetics of artemether and lumefantrine (Riamet®) Clin Drug Invest 18 467 480
11. WH Wernsdorfer 2004 Coartemether (artemether and lumefantrine): an oral antimalarial drug Expert Rev Anti-infect Ther 2 181 196
12. + currents by antimalarial drugs in stably transfected HEK293 cells Eur J Pharmacol 484 41 48
13. rd millennium Wien Klin Wochenschr 115 Suppl 3 2 9