메뉴 건너뛰기




Volumn 2, Issue 2, 2004, Pages 181-196

Coartemether (artemether and lumefantrin): An oral antimalarial drug

Author keywords

Artemether; Coarremether; Lumefantrine; Malaria; Plasmodium falciparum; Plasmodium vivax

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE; ATOVAQUONE PLUS PROGUANIL; BENFLUMETOL; CHLOROQUINE; CHLORPROGUANIL; CHLORPROGUANIL PLUS DAPSONE; DESBUTYLBENFLUMETOL; DIHYDROARTEMISININ; DOXYCYCLINE; DRUG METABOLITE; FANSIDAR; HALOFANTRINE; KETOCONAZOLE; LENNON; MEFLOQUINE; NAPTHOQUINE; PRIMAQUINE; PYRIMETHAMINE; QUININE; QUININE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; SESQUITERPENE;

EID: 85047692367     PISSN: 14787210     EISSN: None     Source Type: Journal    
DOI: 10.1586/14787210.2.2.181     Document Type: Review
Times cited : (59)

References (69)
  • 1
    • 0003997298 scopus 로고    scopus 로고
    • WHO Expert Committee on Malaria, 20th report
    • World Health Organization
    • World Health Organization. WHO Expert Committee on Malaria, 20th report. WHO Tech. Rep. Ser. 892, 3 (2000).
    • (2000) WHO Tech. Rep. Ser. , vol.892 , pp. 3
  • 2
    • 0842334566 scopus 로고    scopus 로고
    • Malaria at the turn from the 2nd to the 3rd millennium
    • Wernsdorfer G, Wernsdorfer W. Malaria at the turn from the 2nd to the 3rd millennium. Wien. Klin. Wochenschr. 115(Suppl. 3), 2-9 (2003).
    • (2003) Wien. Klin. Wochenschr. , vol.115 , Issue.SUPPL. 3 , pp. 2-9
    • Wernsdorfer, G.1    Wernsdorfer, W.2
  • 4
    • 0003473861 scopus 로고    scopus 로고
    • The use of antimalarial drugs. Report of a WHO informal consultation
    • World Health Organization. WHO Document WHO/CDS/RBM/2001.33. World Health Organization, Geneva, Switzerland
    • World Health Organization. The use of antimalarial drugs. Report of a WHO informal consultation. WHO Document WHO/CDS/RBM/2001.33. World Health Organization, Geneva, Switzerland, 47-50 (2001).
    • (2001) , pp. 47-50
  • 5
    • 0003588734 scopus 로고    scopus 로고
    • Antimalarial drug combination therapy. Report of a WHO technical consultation
    • World Health Organization. WHO Document WHO/CDS/RBM/2001.35. World Health Organization, Geneva, Switzerland
    • World Health Organization. Antimalarial drug combination therapy. Report of a WHO technical consultation. WHO Document WHO/CDS/RBM/2001.35. World Health Organization, Geneva, Switzerland, 6-28 (2001).
    • (2001) , pp. 6-28
  • 6
    • 0141517670 scopus 로고    scopus 로고
    • Comparative clinical trial of two fixed combinations dihydroartemisinin-naphthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand
    • Krudsood S, Chalermut K, Pengruksa C et al. Comparative clinical trial of two fixed combinations dihydroartemisinin-naphthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand. Southeast Asian J. Trop. Med. Public Health 34, 316-321 (2003).
    • (2003) Southeast Asian J. Trop. Med. Public Health , vol.34 , pp. 316-321
    • Krudsood, S.1    Chalermut, K.2    Pengruksa, C.3
  • 7
    • 0033784974 scopus 로고    scopus 로고
    • Artemether-lumefantrine for the treatment of multidrug resistant falciparum malaria
    • van Vugt M, Looareesuwan S, Wilairatana P et al. Artemether-lumefantrine for the treatment of multidrug resistant falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 94, 545-548 (2000).
    • (2000) Trans. R. Soc. Trop. Med. Hyg. , vol.94 , pp. 545-548
    • van Vugt, M.1    Looareesuwan, S.2    Wilairatana, P.3
  • 8
    • 0002521085 scopus 로고    scopus 로고
    • Positioning, labeling and medical information control of co-artemether tablets (CPG 56697): A fixed novel combination of artemether and benflumetol
    • Novartis Co-Artemether International Development Team
    • Skelton-Stroud P, Mull R. Positioning, labeling and medical information control of co-artemether tablets (CPG 56697): a fixed novel combination of artemether and benflumetol. Novartis Co-Artemether International Development Team. Med. Trop. 53 (Suppl. 3), 77-81 (1998).
    • (1998) Med. Trop. , vol.53 , Issue.SUPPL. 3 , pp. 77-81
    • Skelton-Stroud, P.1    Mull, R.2
  • 9
    • 0034907150 scopus 로고    scopus 로고
    • Chemotherapeutic approaches to protozoa: Haemosporina - Current level of knowledge and outlook
    • Harder A, Greif G, Haberkorn A. Chemotherapeutic approaches to protozoa: haemosporina - current level of knowledge and outlook. Parasitol. Res. 87, 781-784 (2001).
    • (2001) Parasitol. Res. , vol.87 , pp. 781-784
    • Harder, A.1    Greif, G.2    Haberkorn, A.3
  • 10
    • 0020097279 scopus 로고
    • The chemistry and synthesis of Qinghaosu derivatives
    • China Co-operative Research Group on Qinghaosu and its Derivatives as Antimalarials
    • China Co-operative Research Group on Qinghaosu and its Derivatives as Antimalarials. The chemistry and synthesis of Qinghaosu derivatives. J. Tradit. Chin. Med. 2, 3-8 (1982).
    • (1982) J. Tradit. Chin. Med. , vol.2 , pp. 3-8
  • 11
    • 0004320488 scopus 로고
    • Practical chemotherapy of malaria
    • World Health Organization. Report of a WHO Scientific Group
    • World Health Organization. Practical chemotherapy of malaria. Report of a WHO Scientific Group. WHO Tech. Rep. Ser. 805. 124-126 (1990).
    • (1990) WHO Tech. Rep. Ser. , vol.805 , pp. 124-126
  • 12
    • 0031261051 scopus 로고    scopus 로고
    • Crystal and molecular structure of the antimalarial agent α-(dibutylaminomethyl)-2, 7-dichloro-9-(p-chlorobenzylidene)-4-fluorenemethanol (benflumetol)
    • Zhong JX, Deng RX, Wang J, Zheng QT, Jiao KF. Crystal and molecular structure of the antimalarial agent α -(dibutylaminomethyl)-2, 7-dichloro-9-(p-chlorobenzylidene -4-fluorenemethanol (benflumetol). Yao Xue Xue Bao 32, 824-829 (1997).
    • (1997) Yao Xue Xue Bao , vol.32 , pp. 824-829
    • Zhong, J.X.1    Deng, R.X.2    Wang, J.3    Zheng, Q.T.4    Jiao, K.F.5
  • 13
    • 0032525989 scopus 로고    scopus 로고
    • Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa
    • Wernsdorfer WH, Landgraf B, Kilimali VA, Wernsdorfer G. Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa. Acta Tropica 70, 9-15 (1998).
    • (1998) Acta Tropica , vol.70 , pp. 9-15
    • Wernsdorfer, W.H.1    Landgraf, B.2    Kilimali, V.A.3    Wernsdorfer, G.4
  • 14
    • 0029146165 scopus 로고
    • Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies
    • Navaratnam V, Mansor SM, Chin LK, Mordi MN, Asokan M, Nair NK. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J. Chromatogr. 699, 289-294 (1995).
    • (1995) J. Chromatogr. , vol.699 , pp. 289-294
    • Navaratnam, V.1    Mansor, S.M.2    Chin, L.K.3    Mordi, M.N.4    Asokan, M.5    Nair, N.K.6
  • 15
    • 0037099763 scopus 로고    scopus 로고
    • Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma
    • Souppart C, Gauduchau N, Sandrenan N, Richard F. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 774, 195-202 (2002).
    • (2002) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.774 , pp. 195-202
    • Souppart, C.1    Gauduchau, N.2    Sandrenan, N.3    Richard, F.4
  • 16
    • 0030013737 scopus 로고    scopus 로고
    • Determination of benflumetol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection
    • Zeng MY, Lu ZL, Yang SC et al. Determination of benflumetol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr. B. Biomed. Appl. 681, 299-306 (1996).
    • (1996) J. Chromatogr. B. Biomed. Appl. , vol.681 , pp. 299-306
    • Zeng, M.Y.1    Lu, Z.L.2    Yang, S.C.3
  • 17
    • 0030581186 scopus 로고    scopus 로고
    • Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography
    • Mansor SM, Navaratnam V, Yahaya N, Nair NK, Wernsdorfer WH, Degen PH. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. J. Chromatogr. 682, 321-325 (1996).
    • (1996) J. Chromatogr. , vol.682 , pp. 321-325
    • Mansor, S.M.1    Navaratnam, V.2    Yahaya, N.3    Nair, N.K.4    Wernsdorfer, W.H.5    Degen, P.H.6
  • 18
    • 0034816441 scopus 로고    scopus 로고
    • A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo
    • Chimanuka B, Francois G, Timperman G et al. A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo. Parasitol. Res. 87, 795-803 (2001).
    • (2001) Parasitol. Res. , vol.87 , pp. 795-803
    • Chimanuka, B.1    Francois, G.2    Timperman, G.3
  • 19
    • 0242317284 scopus 로고    scopus 로고
    • Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with hemin
    • Messori L, Piccioli F, Eitler B, Bergonzi MC, Bilia AR, Vincieri FF. Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with hemin. Bioorg. Me. Chem. Lett. 13, 4055-4057 (2003).
    • (2003) Bioorg. Me. Chem. Lett. , vol.13 , pp. 4055-4057
    • Messori, L.1    Piccioli, F.2    Eitler, B.3    Bergonzi, M.C.4    Bilia, A.R.5    Vincieri, F.F.6
  • 20
    • 17344382730 scopus 로고    scopus 로고
    • A randomized controlled trial of artemether/benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children
    • von Seidlein L, Bojang K, Jones P et al. A randomized controlled trial of artemether/benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children. Am. J. Trop. Med. Hyg. 58, 638-644 (1998).
    • (1998) Am. J. Trop. Med. Hyg. , vol.58 , pp. 638-644
    • von Seidlein, L.1    Bojang, K.2    Jones, P.3
  • 24
    • 0033793944 scopus 로고    scopus 로고
    • Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during 5 years of extensive use of artesunate-mefloquine
    • Brockman A, Price RN, van Vugt M et al. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during 5 years of extensive use of artesunate-mefloquine. Trans. R. Soc. Trop. Med. Hyg. 94, 537-544 (2000).
    • (2000) Trans. R. Soc. Trop. Med. Hyg. , vol.94 , pp. 537-544
    • Brockman, A.1    Price, R.N.2    van Vugt, M.3
  • 27
    • 0031711884 scopus 로고    scopus 로고
    • In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon
    • Basco LK, Bickii J, Ringwald P. In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon. Antimicrob. Agents Chemother. 42, 2347-2351 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2347-2351
    • Basco, L.K.1    Bickii, J.2    Ringwald, P.3
  • 28
    • 0033023732 scopus 로고    scopus 로고
    • In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs
    • Pradines B, Tall A, Fusai T et al. In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Antimicrob. Agents Chemother. 43, 418-420 (1999).
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 418-420
    • Pradines, B.1    Tall, A.2    Fusai, T.3
  • 29
    • 0033380993 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of artemether and lumefantrine (Riamet®)
    • Lefèvre G, Thomsen MS. Clinical pharmacokinetics of artemether and lumefantrine (Riamet®). Clin. Drug Invest. 18, 467-480 (1999).
    • (1999) Clin. Drug Invest. , vol.18 , pp. 467-480
    • Lefèvre, G.1    Thomsen, M.S.2
  • 30
    • 0034950952 scopus 로고    scopus 로고
    • Desbutyl-benflumetol, a novel antimalarial compound: In vitro activity in fresh isolates of Plasmodium falciparum from Thailand
    • Noedl H, Allmendinger T, Prajakwong S, Wernsdorfer G, Wernsdorfer WH. Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand. Antimicrob. Agents Chemother. 45, 2106-2109 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2106-2109
    • Noedl, H.1    Allmendinger, T.2    Prajakwong, S.3    Wernsdorfer, G.4    Wernsdorfer, W.H.5
  • 32
    • 0842291591 scopus 로고    scopus 로고
    • In vitro sensitivity testing of Plasmodium vivax: Response to lumefantrine and chloroquine in northwestern Thailand
    • Lux D, Prajakwong S, Kollaritsch H, Wernsdorfer G, Wernsdorfer WH. In vitro sensitivity testing of Plasmodium vivax: response to lumefantrine and chloroquine in northwestern Thailand. Wien. Klin. Wochenschrift 115(Suppl.3), 50-54 (2003).
    • (2003) Wien. Klin. Wochenschrift , vol.115 , Issue.SUPPL. 3 , pp. 50-54
    • Lux, D.1    Prajakwong, S.2    Kollaritsch, H.3    Wernsdorfer, G.4    Wernsdorfer, W.H.5
  • 33
    • 0344549158 scopus 로고    scopus 로고
    • Synergism of benflumetol and artemether in Plasmodium falciparum
    • Alin H, Bjorkman A, Wernsdorfer WH. Synergism of benflumetol and artemether in Plasmodium falciparum. Am. J. Trop. Med. Hyg. 61, 439-445 (1999).
    • (1999) Am. J. Trop. Med. Hyg. , vol.61 , pp. 439-445
    • Alin, H.1    Bjorkman, A.2    Wernsdorfer, W.H.3
  • 34
    • 2442614219 scopus 로고    scopus 로고
    • Molecular markers for drug resistance in malaria: Use in treatment, diagnosis and epidemiology
    • Wernsdorfer WH, Noedl H. Molecular markers for drug resistance in malaria: use in treatment, diagnosis and epidemiology. Curr. Opin. Infect. Dis. 16, 553-558 (2003).
    • (2003) Curr. Opin. Infect. Dis. , vol.16 , pp. 553-558
    • Wernsdorfer, W.H.1    Noedl, H.2
  • 35
    • 0034106867 scopus 로고    scopus 로고
    • In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether
    • Tanariya P, Tippawangkoso P, Karbwang J, Na-Bangchang K, Wernsdorfer WH. In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether. Br. J. Clin. Pharmacol. 49, 437-444 (2000).
    • (2000) Br. J. Clin. Pharmacol. , vol.49 , pp. 437-444
    • Tanariya, P.1    Tippawangkoso, P.2    Karbwang, J.3    Na-Bangchang, K.4    Wernsdorfer, W.H.5
  • 36
    • 0029616401 scopus 로고
    • Predictors of mefloquine treatment failure: A prospective study in 1590 patients with uncomplicated falciparum malaria
    • ter Kuile FO, Luxemburger F, Nosten F et al. Predictors of mefloquine treatment failure: a prospective study in 1590 patients with uncomplicated falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 89, 660-664 (1995).
    • (1995) Trans. R. Soc. Trop. Med. Hyg. , vol.89 , pp. 660-664
    • ter Kuile, F.O.1    Luxemburger, F.2    Nosten, F.3
  • 37
    • 0032862673 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine
    • White NJ, van Vugt M, Ezzet F. Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine. Clin. Pharmacokinet. 37, 105-125 (1999).
    • (1999) Clin. Pharmacokinet. , vol.37 , pp. 105-125
    • White, N.J.1    van Vugt, M.2    Ezzet, F.3
  • 38
    • 0141905757 scopus 로고    scopus 로고
    • Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers
    • Go ML, Li QT. Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers. Chem. Pharm. Bull. 51, 241-246 (2003).
    • (2003) Chem. Pharm. Bull. , vol.51 , pp. 241-246
    • Go, M.L.1    Li, Q.T.2
  • 39
    • 0030905911 scopus 로고    scopus 로고
    • Prolongation of the QTc interval in African children treated for falciparum malaria
    • von Seidlein L, Jaffar S, Greenwood B. Prolongation of the QTc interval in African children treated for falciparum malaria. Am. J. Trop. Med. Hyg. 56, 494-497 (1997).
    • (1997) Am. J. Trop. Med. Hyg. , vol.56 , pp. 494-497
    • von Seidlein, L.1    Jaffar, S.2    Greenwood, B.3
  • 40
    • 0033386669 scopus 로고    scopus 로고
    • No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine
    • van Vugt M, Ezzet, F., Nosten F et al. No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine. Am. J. Trop. Med. Hyg. 61, 964-967 (1999).
    • (1999) Am. J. Trop. Med. Hyg. , vol.61 , pp. 964-967
    • van Vugt, M.1    Ezzet, F.2    Nosten, F.3
  • 41
    • 0036309852 scopus 로고    scopus 로고
    • Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants
    • Bindschedler M, Lefèvre G, Degen P, Sioufi A. Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants. Am. J. Trop. Med. Hyg. 66, 295-300 (2002).
    • (2002) Am. J. Trop. Med. Hyg. , vol.66 , pp. 295-300
    • Bindschedler, M.1    Lefèvre, G.2    Degen, P.3    Sioufi, A.4
  • 42
    • 0033844418 scopus 로고    scopus 로고
    • Cardiac effects of co-artemether (artemether/lumefantrine) and mefloquine given alone or in combination to healthy volunteers
    • Bindschedler M, Lefèvre G, Ezzet F, Schaeffer N, Meyer I, Thomsen MS. Cardiac effects of co-artemether (artemether/lumefantrine) and mefloquine given alone or in combination to healthy volunteers. Eur. J. Clin. Pharmacol. 56, 375-381 (2000).
    • (2000) Eur. J. Clin. Pharmacol. , vol.56 , pp. 375-381
    • Bindschedler, M.1    Lefèvre, G.2    Ezzet, F.3    Schaeffer, N.4    Meyer, I.5    Thomsen, M.S.6
  • 44
    • 0032860379 scopus 로고    scopus 로고
    • Binding of artemether and lumefantrine to plasma proteins and erythrocytes
    • Colussi D, Parisot C, Leagay F, Lefèvre G. Binding of artemether and lumefantrine to plasma proteins and erythrocytes. Eur. J. Pharmaceut. Sci. 9, 9-16 (1999).
    • (1999) Eur. J. Pharmaceut. Sci. , vol.9 , pp. 9-16
    • Colussi, D.1    Parisot, C.2    Leagay, F.3    Lefèvre, G.4
  • 45
    • 0033067324 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria
    • van Agtmael MA, Cheng-Qi S, Qing JX, Mull R, van Boxtel CJ. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int. J. Antimicrob. Agents 12, 151-158 (1999).
    • (1999) Int. J. Antimicrob. Agents , vol.12 , pp. 151-158
    • van Agtmael, M.A.1    Cheng-Qi, S.2    Qing, J.X.3    Mull, R.4    van Boxtel, C.J.5
  • 46
    • 0034968177 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of antimalarial agents
    • Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin. Pharmacokinet. 40, 343-373 (2001).
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 343-373
    • Giao, P.T.1    de Vries, P.J.2
  • 47
    • 0034946077 scopus 로고    scopus 로고
    • A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug resistant Plasmodium falciparum malaria in Thailand
    • Lefèvre G, Looareesuwan S, Treeprasertsuk S et al. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug resistant Plasmodium falciparum malaria in Thailand. Am. J. Trop. Med. Hyg. 64, 247-256(2001).
    • (2001) Am. J. Trop. Med. Hyg. , vol.64 , pp. 247-256
    • Lefèvre, G.1    Looareesuwan, S.2    Treeprasertsuk, S.3
  • 48
    • 0033402421 scopus 로고    scopus 로고
    • Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria
    • Na-Bangchang K, Karbwang J, Tasanor U, Thanavibul A, Farkad E, Mull R. Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria. Int. J. Clin. Pharmacol. Res. 19, 41-46 (1999).
    • (1999) Int. J. Clin. Pharmacol. Res. , vol.19 , pp. 41-46
    • Na-Bangchang, K.1    Karbwang, J.2    Tasanor, U.3    Thanavibul, A.4    Farkad, E.5    Mull, R.6
  • 49
    • 0031753648 scopus 로고    scopus 로고
    • Population pharmacokinetics and therapeutic response of CGP 56697 (artemether and benflumetol) in malaria patients
    • Ezzet F, Mull R, Karbwang J. Population pharmacokinetics and therapeutic response of CGP 56697 (artemether and benflumetol) in malaria patients. Br. J. Clin. Pharmacol. 46, 553-561 (1998).
    • (1998) Br. J. Clin. Pharmacol. , vol.46 , pp. 553-561
    • Ezzet, F.1    Mull, R.2    Karbwang, J.3
  • 51
    • 0036785445 scopus 로고    scopus 로고
    • Interaction trial between artemether-lumefantrine (Riamet®) and quinine in healthy subjects
    • Lefèvre G, Carpenter P, Souppart C et al., Interaction trial between artemether-lumefantrine (Riamet®) and quinine in healthy subjects. J. Clin. Pharmacol. 42, 1147-1158 (2002).
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 1147-1158
    • Lefèvre, G.1    Carpenter, P.2    Souppart, C.3
  • 52
    • 0036435747 scopus 로고    scopus 로고
    • Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects
    • Lefèvre G, Carpenter P, Souppart C, Schmidli H, McClean M, Stypinski D. Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br. J. Clin. Pharmacol. 54, 485-492 (2002).
    • (2002) Br. J. Clin. Pharmacol. , vol.54 , pp. 485-492
    • Lefèvre, G.1    Carpenter, P.2    Souppart, C.3    Schmidli, H.4    McClean, M.5    Stypinski, D.6
  • 53
    • 0031219219 scopus 로고
    • Phase II trial in China of a new, rapidly-acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria
    • Jiao X, Liu GY, Shan CO et al. Phase II trial in China of a new, rapidly-acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria. Southeast Asian J. Trop. Med. Public Health 28, 476-481 (1977).
    • (1977) Southeast Asian J. Trop. Med. Public Health , vol.28 , pp. 476-481
    • Jiao, X.1    Liu, G.Y.2    Shan, C.O.3
  • 54
    • 0042787928 scopus 로고    scopus 로고
    • Clinical comparative trial of coartemether and benflumetol (two formulations) in the treatment of falciparum malaria
    • Sun ZW, Shan CQ, Li GF et al. Clinical comparative trial of coartemether and benflumetol (two formulations) in the treatment of falciparum malaria. Zhongguo J. Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 18, 159-161 (2000).
    • (2000) Zhongguo J. Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi , vol.18 , pp. 159-161
    • Sun, Z.W.1    Shan, C.Q.2    Li, G.F.3
  • 55
    • 0033779429 scopus 로고    scopus 로고
    • A randomized double-blind, parallel-group, comparative safety and efficacy trial of oral coartemether versus oral chloroquine in die treatment of acute uncomplicated Plasmodium falciparum malaria in adults in India
    • Kshirsagar NA, Gogtay NJ, Moorthy NS et al. A randomized double-blind, parallel-group, comparative safety and efficacy trial of oral coartemether versus oral chloroquine in die treatment of acute uncomplicated Plasmodium falciparum malaria in adults in India. Am. J. Trop. Med. Hyg. 62, 402-408 (2000).
    • (2000) Am. J. Trop. Med. Hyg. , vol.62 , pp. 402-408
    • Kshirsagar, N.A.1    Gogtay, N.J.2    Moorthy, N.S.3
  • 56
    • 0033038463 scopus 로고    scopus 로고
    • The comparative efficacy and tolerability of CGP 56697 (artemether and lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travelers returning from the tropics to The Netherlands and France
    • van Agtmael M, Bouchaud O, Malvy D et al. The comparative efficacy and tolerability of CGP 56697 (artemether and lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travelers returning from the tropics to The Netherlands and France. Int. J. Antimicrob. Agents 12, 159-169 (1999).
    • (1999) Int. J. Antimicrob. Agents , vol.12 , pp. 159-169
    • van Agtmael, M.1    Bouchaud, O.2    Malvy, D.3
  • 57
    • 0033048031 scopus 로고    scopus 로고
    • A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand
    • Looareesuwan S, Wilairatana P, Chokejindachai W et al. A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. Am. J. Trop. Med. Hyg. 60, 238-243 (1999).
    • (1999) Am. J. Trop. Med. Hyg. , vol.60 , pp. 238-243
    • Looareesuwan, S.1    Wilairatana, P.2    Chokejindachai, W.3
  • 58
    • 0031973150 scopus 로고    scopus 로고
    • Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug resistant falciparum
    • van Vugt M, Brockman A, Gemperli B et al. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug resistant falciparum. Antimicrob. Agents Chemother. 42, 135-139 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 135-139
    • van Vugt, M.1    Brockman, A.2    Gemperli, B.3
  • 59
    • 0033784974 scopus 로고    scopus 로고
    • Artemether-lumefantrine for the treatment of multidrug resistant falciparum malaria
    • van Vugt M, Looareesuwan S, Wilairatana P et al. Artemether-lumefantrine for the treatment of multidrug resistant falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 94, 545-548 (2000).
    • (2000) Trans. R. Soc. Trop. Med. Hyg. , vol.94 , pp. 545-548
    • van Vugt, M.1    Looareesuwan, S.2    Wilairatana, P.3
  • 60
    • 0033027432 scopus 로고    scopus 로고
    • Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug resistant Plasmodium falciparum malaria
    • van Vugt M, Wilairatana P, Gemperli B et al. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug resistant Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 60, 936-942 (1999).
    • (1999) Am. J. Trop. Med. Hyg. , vol.60 , pp. 936-942
    • van Vugt, M.1    Wilairatana, P.2    Gemperli, B.3
  • 61
    • 0030812746 scopus 로고    scopus 로고
    • Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697
    • von Seidlein L, Jaffar S, Pinder M et al. Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697. J. Infect. Dis. 176, 1113-1116 (1997).
    • (1997) J. Infect. Dis. , vol.176 , pp. 1113-1116
    • von Seidlein, L.1    Jaffar, S.2    Pinder, M.3
  • 62
    • 0031777975 scopus 로고    scopus 로고
    • Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years
    • Hatz C, Abdulla S, Mull R et al. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years. Trop. Med. Int. Health 3, 498-504 (1998).
    • (1998) Trop. Med. Int. Health , vol.3 , pp. 498-504
    • Hatz, C.1    Abdulla, S.2    Mull, R.3
  • 63
    • 0031800628 scopus 로고    scopus 로고
    • Distinction of recrudescences from new infections by PCR-RFLP analysis in a comparative trial of CGP 56697 and chloroquine in Tanzanian children
    • Irion A, Felger I, Abdulla S et al. Distinction of recrudescences from new infections by PCR-RFLP analysis in a comparative trial of CGP 56697 and chloroquine in Tanzanian children. Trop. Med. Int. Health 3, 490-497 (1998).
    • (1998) Trop. Med. Int. Health , vol.3 , pp. 490-497
    • Irion, A.1    Felger, I.2    Abdulla, S.3
  • 66
    • 0028338629 scopus 로고
    • Neurotoxicity in animals due to arteether and artemether
    • Brewer TG, Peggins JO, Grate SJ et al. Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl.1), 33-36 (1994).
    • (1994) Trans. R. Soc. Trop. Med. Hyg. , vol.88 , Issue.SUPPL. 1 , pp. 33-36
    • Brewer, T.G.1    Peggins, J.O.2    Grate, S.J.3
  • 67
    • 0033847345 scopus 로고    scopus 로고
    • An integrated assessment of the clinical safety of artemether-lumefantrine: A new oral fixed-dose combination antimalarial drug
    • Bakshi R, Hermeling-Fritz I, Gathmann I, Alteri E. An integrated assessment of the clinical safety of artemether-lumefantrine: a new oral fixed-dose combination antimalarial drug. Trans. R. Soc. Trop. Med. Hyg. 94, 419-424 (2000).
    • (2000) Trans. R. Soc. Trop. Med. Hyg. , vol.94 , pp. 419-424
    • Bakshi, R.1    Hermeling-Fritz, I.2    Gathmann, I.3    Alteri, E.4
  • 68
    • 0035893146 scopus 로고    scopus 로고
    • Artemisinin antimalarials in pregnancy: A prospective study of 539 episodes of multidrug resistant Plasmodium falciparum
    • McGready R, Cho T, Keo NM et al. Artemisinin antimalarials in pregnancy: a prospective study of 539 episodes of multidrug resistant Plasmodium falciparum. Clin. Infect. Dis. 33, 2009-2016 (2001).
    • (2001) Clin. Infect. Dis. , vol.33 , pp. 2009-2016
    • McGready, R.1    Cho, T.2    Keo, N.M.3
  • 69
    • 0028258342 scopus 로고
    • Epidemiology of drug resistance in malaria
    • Wernsdorfer WH. Epidemiology of drug resistance in malaria. Acta Tropica 56, 143-156 (1994).
    • (1994) Acta Tropica , vol.56 , pp. 143-156
    • Wernsdorfer, W.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.