Desbutyl-benflumetol, a novel antimalarial compound: In vitro activity in fresh isolates of Plasmodium falciparum from Thailand

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 7, 2001, Pages 2106-2109

  Noedl, H ^a   Allmendinger, T ^a   Prajakwong, S ^a   Wernsdorfer, G ^a   Wernsdorfer, W H ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL; ANTIMALARIAL AGENT; AROMATIC AMINE; ARTEMISININ; ATOVAQUONE; BENFLUMETOL; CHLOROQUINE; DESBUTYLBENFLUMETOL; DRUG METABOLITE; MEFLOQUINE; QUININE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CORRELATION FUNCTION; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; DRUG SENSITIVITY; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT; STANDARD; THAILAND;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; ETHANOLAMINES; FLUORENES; HUMANS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; THAILAND;

EID: 0034950952     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.7.2106-2109.2001     Document Type: Article

References (19)

1. Synergism of benflumetol and artemether in Plasmodium falciparum
2. Population pharmacokinetics and therapeutic response of CGP 56697 (artemether + benflumetol) in malaria patients
3. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria
4. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years
5. Phase II trial in China of a new, rapidly-acting and oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria
6. A simplified method of evaluating dose-effect experiments
7. Benflumetol: In vitro sensitivity of Plasmodium falciparum in Thailand
8. An in vivo-in vitro model for the assessment of antimalarial cross-resistance
9. Mefloquine resistant falciparum malaria on the Thai-Burmese border
10. Co-artemether: A novel therapy to meet the global malaria challenge
11. Drug sensitivity of Plasmodium falciparum. An in vitro micro technique
12. In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether
13. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria
14. Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697
15. The development and spread of drug resistant malaria
16. Drug sensitivity tests in malaria parasites
17. The evaluation of in vitro tests for the assessment of drug response in Plasmodium falciparum
18. Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa
19. In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand