GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

Developmental Biology

Volumn 325, Issue 1, 2009, Pages 43-48

  Levine, Ariel J ^a   Levine, Zachary J ^a   Brivanlou, Ali H ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

BMP; Embryo; GDF3; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; GROWTH DIFFERENTIATION FACTOR 3; MESSENGER RNA; PROTEIN INHIBITOR; PROTEIN NODAL; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; EMBRYO CELL; EMBRYO DEVELOPMENT; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

EID: 57849096555     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.09.006     Document Type: Article

References (31)

1. Andersson O., et al. Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev. Biol. 311 (2007) 500-511
2. Bachiller D., et al. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403 (2000) 658-661
3. Brennan J., et al. Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411 (2001) 965-969
4. Chen C., et al. The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development 133 (2006) 319-329
5. Cheng S.K., et al. Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors. PLoS Biol. 2 (2004) E30
6. Daluiski A., et al. Bone morphogenetic protein-3 is a negative regulator of bone density. Nat. Genet. 27 (2001) 84-88
7. Dosch R., et al. Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development 124 (1997) 2325-2334
8. Ferguson E.L., and Anderson K.V. Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71 (1992) 451-461
9. Green J.B., and Smith J.C. Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347 (1990) 391-394
10. Green J.B., et al. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71 (1992) 731-739
11. Grunz H., and Tacke L. Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer. Cell Differ. Dev. 28 (1989) 211-217
12. Hata A., et al. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100 (2000) 229-240
13. Huang H.C., et al. Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo. EMBO J. 14 (1995) 5965-5973
14. Joseph E.M., and Melton D.A. Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development 125 (1998) 2677-2685
15. Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
16. Lee S.J. Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol. Endocrinol. 4 (1990) 1034-1040
17. Levine A.J., and Brivanlou A.H. GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos. Development 133 (2006) 209-216
18. Meno C., et al. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4 (1999) 287-298
19. Peerani R., et al. Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. 26 (2007) 4744-4755
20. Rankin C.T., et al. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat. Genet. 24 (2000) 262-265
21. Rodriguez T.A., et al. Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm. Development 132 (2005) 2513-2520
22. Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
23. Smith J.C. A mesoderm-inducing factor is produced by Xenopus cell line. Development 99 (1987) 3-14
24. Soares M.L., et al. Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi. BMC Dev. Biol. 5 (2005) 28
25. Thomsen G., et al. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63 (1990) 485-493
26. Thomsen G.H., and Melton D.A. Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell 74 (1993) 433-441
27. Wall N.A., et al. Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene. Dev. Biol. 227 (2000) 495-509
28. Wilson P.A., and Hemmati-Brivanlou A. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376 (1995) 331-333
29. Wilson P.A., et al. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124 (1997) 3177-3184
30. Xu R.H., et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat. Biotechnol. 20 (2002) 1261-1264
31. Yeo C., and Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol. Cell. 7 (2001) 949-957