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Volumn 129, Issue 23, 2008, Pages

Charge-transport-mediated recruitment of DNA repair enzymes

Author keywords

[No Author keywords available]

Indexed keywords

ATOMS; CATALYSTS; DNA; ELECTRIC INSTRUMENT TRANSFORMERS; ELECTRONS; GENES; MAINTENANCE; MONTE CARLO METHODS; NUCLEIC ACIDS; ORGANIC ACIDS; POSITIVE IONS; PROBABILITY DISTRIBUTIONS; PROTEINS; REPAIR; STOCHASTIC MODELS;

EID: 57849085252     PISSN: 00219606     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.3026735     Document Type: Article
Times cited : (16)

References (40)
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    • Coli, the maximum deposition rate can be obtained by assuming a nucleoid radius of approximately b≈0.3 μm. Upon assuming a MutY diffusivity of D∼3× 10-7 cm2 /s, the Debye-Smoluchowski estimate is kon ∼4π Db≈6× 1010 M-1 s-1. For MutY concentration of C≈20 enzymes/femtoliter, the average time between depositions is (kC) -1 ≈0.0005 s.
    • For E. Coli, the maximum deposition rate can be obtained by assuming a nucleoid radius of approximately b≈0.3 μm. Upon assuming a MutY diffusivity of D∼3× 10-7 cm2 /s, the Debye-Smoluchowski estimate is kon ∼4π Db≈6× 1010 M-1 s-1. For MutY concentration of C≈20 enzymes/femtoliter, the average time between depositions is (kC) -1 ≈0.0005 s.
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    • While passive enzymes converge more quickly to enzymes when measured in terms of the deposition number n, CT repair enzymes converge more quickly when measured in terms of the number of adsorptions m=O (n1/3). In fact, the enzyme-lesion distance for repair enzymes scales as O (n-2/3) =O (m-2) compared to O (m-1) for passive enzymes with m=n (every deposition results in an adsorption).
    • While passive enzymes converge more quickly to enzymes when measured in terms of the deposition number n, CT repair enzymes converge more quickly when measured in terms of the number of adsorptions m=O (n1/3). In fact, the enzyme-lesion distance for repair enzymes scales as O (n-2/3) =O (m-2) compared to O (m-1) for passive enzymes with m=n (every deposition results in an adsorption).


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