Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?

American Journal of Hypertension

Volumn 22, Issue 1, 2009, Pages 80-86

  Hahntow, Ines N ^a   Mairuhu, Gideon ^a   Van Valkengoed, Irene G M ^a   Baas, Frank ^a   Alewijnse, Astrid E ^a   Koopmans, Richard P ^a,b   Michel, Martin C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

RGS2 PROTEIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; DNA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HELIX-LOOP-HELIX MOTIFS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NETHERLANDS; POLYMORPHISM, GENETIC; PREVALENCE; PROGNOSIS; RGS PROTEINS; SEX DISTRIBUTION;

EID: 57749210202     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2008.310     Document Type: Article

References (38)

1. Insel PA, Tang CM, Hahntow I, Michel MC. Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets. Biochim Biophys Acta 2007; 1768:994-1005.
2. Ladds G, Goddard A, Hill C, Thornton S, Davey J. Differential effects of RGS proteins on Gαq and Gα11 activity. Cell Signal 2007; 19:103-113.
3. Hendriks-Balk MC, Peters SLM, Michel MC, Alewijnse AE. Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins. Eur J Pharmacol 2008; 585:278-291.
4. Osei-Owusu P, Sun X, Drenan RM, Steinberg TH, Blumer KJ. Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase. J Biol Chem 2007; 282:31656-31665.
5. 2β) participates in angiotensin II-induced transcriptional upregulation of regulator of G-protein signaling-2 in vascular smooth muscle cells. J Biol Chem 2007; 282:25278-25289.
6. Semplicini A, Lenzini L, Sartori M, Papparella I, Calo LA, Pagnin E, Strapazzon G, Benna C, Costa R, Avogaro A, Ceolotto G, Pessina AC. Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. J Hypertens 2006; 24:1125-1135.
7. Wieland T, Lutz S, Chidiac P. Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system. Curr Opin Pharmacol 2007; 7:201-207.
8. De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG. The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 2000; 40:235-271.
9. Calo LA, Pagnin E, Ceolotto G, Davis PA, Schiavo S, Papparella I, Semplicini A, Pessina AC. Silencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes. J Hypertens 2008; 26:938-945.
10. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 2003; 9:1506-1512.
11. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 2003; 111: 445-452.
12. Calo LA, Pagnin E, Davis PA, Sartori M, Ceolotto G, Pessina AC, Semplicini A. Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension. J Clin Endocrinol Metab 2004; 89: 4153-4157.
13. Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension 2006; 47:415-420.
14. Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T. Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. J Hypertens 2005; 23:1497-1505.
15. Gu S, Tirgari S, Heximer S. RGS2 gene product from candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq. FASEB J 2008; 22:1044.5.
16. Freson K, Stolarz K, Aerts R, Brand E, Brand-Herrmann SM, Kawecka-Jaszcz K, Kuznetsova T, Tikhonoff V, Thijs L, Vermylen J, Staessen JA, Van Geet C; European Project on Genes in Hypertension Investigators. -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies. J Hypertens 2007; 25:117-125.
17. Michel MC, Hahntow I, Koopmans RP. Multiple gene approaches to delineate the role of the renin-angiotensin-aldosterone system in nephropathy. J Hypertens 2005; 23:269-272.
18. Rosskopf D, Schürks M, Rimmbach C, Schäfers R. Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol 2007; 374:429-469.
19. Schulze TG, McMahon FJ. Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Hum Hered 2004; 58:131-138.
20. Agyemang C, Bindraban N, Mairuhu G, Montfrans G, Koopmans R, Stronks K. Prevalence, awareness, treatment, and control of hypertension among Black Surinamese, South Asian Surinamese and White Dutch in Amsterdam, The Netherlands: the SUNSET study. J Hypertens 2005; 23:1971-1977.
21. Bindraban N, van Valkengoed IGM, Mairuhu G, Koster RW, Holleman F, Hoekstra JB, Koopmans RP, Stronks K. A new tool, a better tool? Prevalence and performance of the International Diabetes Federation and the National Cholesterol Education Program criteria for metabolic syndrome in different ethnic groups. Eur J Epidemiol 2008; 23:37-44.
22. Skol AD, Xiao R, Boehnke M. An algorithm to construct genetically similar subsets of families with the use of self-reported ethnicity information. Am J Hum Genet 2005; 77:346-354.
23. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shaddick NA, Reich D. Principal components analysis corrections for stratification in genome-wide association studies. Nat Genet 2006; 38:904-909.
24. Mondorf UF, Russ A, Wiesemann A, Herrero M, Oremek G, Lenz T. Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension. Am J Hypertens 1998; 11:174-183.
25. Sauer S, Gut IG. Genotyping single-nucleotide polymorphisms by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 782:73-87.
26. Zinkstok JR, de Wilde O, van Amelsvoort TAMJ, Tanck MW, Baas F, Linszen DH. Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct 2007; 3:1-10.
27. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
28. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
29. Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet 2005; 76:449-462.
30. Agyemang C, van Valkengoed I, Koopmans R, Stronks K. Factors associated with hypertension awareness, treatment and control among ethnic groups in Amsterdam, The Netherlands: the SUNSET study. J Hum Hypertens 2006; 20:874-881.
31. Rankinen T, Church TS, Rice T, Bouchard C, Blair SN. Cardiorespiratory fitness, BMI, and risk of hypertension: the HYPGENE study. Med Sci Sports Exerc 2007; 39: 1687-1692.
32. Pinto E. Blood pressure and ageing. Postgrad Med J 2007; 83: 109-114.
33. Franklin SS. Hypertension in older people: part 2. J Clin Hypertens (Greenwich) 2006; 8: 521-525.
34. Franklin SS. Hypertension in older people: part 1. J Clin Hypertens (Greenwich) 2006; 8: 444-449.
35. Benjafield AV, Wang WYS, Speirs HJL, Morris BJ. Genome-wide scan for hypertension in Sydney sibships: the GENIHUSS study. Am J Hypertens 2005; 18: 828-832.
36. Rice T, Cooper RS, Wu X, Bouchard C, Rankinen T, Rao DC, Jaquish CE, Fabsitz RR, Province MA. Meta-analysis of genome-wide scans for blood pressure in African American and Nigerian samples. Am J Hypertens 2006; 19: 270-274.
37. Wu X, Kan D, Province M, Quertermous T, Rao DD, Chang C, Mosley TH, Curb D, Boerwinkle E, Cooper RS. An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI family blood pressure program (FBPP). Am J Hypertens 2006; 19:122-127.
38. Antonarakis SE. Recommendations for a nomenclature system for human gene mutations. Nomenclature Working Group. Hum Mutat 1998; 11:1-3.