Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes

Annals of the New York Academy of Sciences

Volumn 1150, Issue , 2008, Pages 112-122

  Bortell, Rita ^a,c   Pino, Steven C ^a   Greiner, Dale L ^a   Zipris, Danny ^b   Rossini, Aldo A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c Diabetes Division   (United States)

Author keywords

Toll like receptors; Type 1A diabetes; Viruses

Indexed keywords

CD3 ANTIBODY; DOCOSAHEXAENOIC ACID; GLUTAMATE DECARBOXYLASE; HEAT SHOCK PROTEIN 60; HLA ANTIGEN CLASS 1; INSULIN ANTIBODY; INTERLEUKIN 2 RECEPTOR ANTIBODY; MICRORNA; OMEGA 3 FATTY ACID; PROTEIN P277; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; ZINC TRANSPORTER;

AUTOIMMUNE DISEASE; BIOMEDICAL TECHNOLOGY ASSESSMENT; CELL ORGANELLE; CELL STRUCTURE; CLINICAL OBSERVATION; CONFERENCE PAPER; DIABETOGENESIS; DISEASE MODEL; ENVIRONMENTAL FACTOR; EXPERIMENTAL MODEL; GENETIC PREDISPOSITION; HEREDITY; HUMAN; IMMUNOPATHOLOGY; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PATIENT MONITORING; VIRUS INFECTION;

ANIMALIA;

EID: 57749205591     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1447.025     Document Type: Conference Paper

References (30)

1. Rossini, A.A., D.L. Greiner, H.P. Fuller & J.P. Mordes. 1993. Immunopathogenesis of diabetes mellitus. Diab. Rev. 1 : 43 75.
2. Mayfield, J. 1998. Diagnosis and classification of diabetes mellitus: new criteria. Am. Fam. Physician 58 : 1355 1370.
3. Rossini, A.A. 2004. From beast to bedside: a commentary. Diabetologia 47 : 1647 1649.
4. Todd, J.A., N.M. Walker, J.D. Cooper, et al. 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39 : 857 864.
5. Rossini, A.A., E.S. Handler, J.P. Mordes & D.L. Greiner. 1995. Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice: caveat emptor. Clin. Immunol. Immunopathol. 74 : 2 9.
6. Van Der, W.N., F.G. Kroese, J. Rozing & J.L. Hillebrands. 2007. Viral infections as potential triggers of type 1 diabetes. Diab. Metab Res. Rev. 23 : 169 183.
7. Honeyman, M. 2005. How robust is the evidence for viruses in the induction of type 1 diabetes? Curr. Opin. Immunol. 17 : 616 623.
8. Filippi, C. & M. Von Herrath. 2005. How viral infections affect the autoimmune process leading to type 1 diabetes. Cell Immunol. 233 : 125 132.
9. Von Herrath, M.G., A. Holz, D. Homann & M.B. Oldstone. 1998. Role of viruses in type I diabetes. Semin. Immunol. 10 : 87 100.
10. Robles, D.T. & G.S. Eisenbarth. 2001. Type 1A diabetes induced by infection and immunization. J. Autoimmun. 16 : 355 362.
11. Rossini, A.A. 2004. Autoimmune diabetes and the circle of tolerance. Diabetes 53 : 267 275.
12. Rossini, A.A., J.P. Mordes & A.A. Like. 1985. Immunology of insulin-dependent diabetes mellitus. Annu. Rev. Immunol. 3 : 289 320.
13. Haverkos, H.W., N. Battula, D.P. Drotman & O.M. Rennert. 2003. Enteroviruses and type 1 diabetes mellitus. Biomed. Pharmacother. 57 : 379 385.
14. Andreoletti, L., D. Hober, C. Hober-Vandenberghe, et al. 1997. Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus. J. Med. Virol. 52 : 121 127.
15. Munakata, Y., T. Kodera, T. Saito & T. Sasaki. 2005. Rheumatoid arthritis, type 1 diabetes, and Graves' disease after acute parvovirus B19 infection. Lancet 366 : 780.
16. Von Herrath, M.G., R.S. Fujinami & J.L. Whitton. 2003. Microorganisms and autoimmunity: making the barren field fertile? Nat. Rev. Microbiol. 1 : 151 157.
17. Shi, F.D., H.G. Ljunggren & N. Sarvetnick. 2001. Innate immunity and autoimmunity: from self-protection to self-destruction. Trends Immunol. 22 : 97 101.
18. Hawa, M.I., H. Beyan, L.R. Buckley & R.D. Leslie. 2002. Impact of genetic and non-genetic factors in type 1 diabetes. Am. J. Med. Genet. 115 : 8 17.
19. Oldstone, M.B. 1988. Prevention of type I diabetes in nonobese diabetic mice by virus infection. Science 239 : 500 502.
20. Hillebrands, J.L., B. Whalen, J.T. Visser, et al. 2006. A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J. Immunol. 177 : 7820 7832.
21. Ellerman, K.E. & A.A. Like. 2000. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43 : 890 898.
22. Guberski, D.L., V.A. Thomas, W.R. Shek, et al. 1991. Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. Science 254 : 1010 1013.
23. Brown, D.W., R.M. Welsh & A.A. Like. 1993. Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats. J. Virol. 67 : 5873 5878.
24. Paronen, J., M. Knip, E. Savilahti, et al. 2000. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes: Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes 49 : 1657 1665.
25. Zipris, D., E. Lien, J.X. Xie, et al. 2005. TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J. Immunol. 174 : 131 142.
26. Zipris, D., J.L. Hillebrands, R.M. Welsh, et al. 2003. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J. Immunol. 170 : 3592 3602.
27. Zipris, D., E. Lien, A. Nair, et al. 2007. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J. Immunol. 178 : 693 701.
28. Skyler, J.S. 2007. Prediction and prevention of type 1 diabetes: progress, problems, and prospects. Clin. Pharmacol. Ther. 81 : 768 771.
29. O'Connell, R.M., K.D. Taganov, M.P. Boldin, et al. 2007. MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. USA 104 : 1604 1609.
30. Majno, G. & I. Joris. 2004. Cells, Tissues, and Disease: Principle of General Pathology. Oxford University Press. New York.