Saturation mutagenesis reveals that GLU54 of norovirus 3C-like protease is not essential for the proteolytic activity

Journal of Biochemistry

Volumn 144, Issue 6, 2008, Pages 771-780

  Someya, Yuichi ^a   Takeda, Naokazu ^a   Wakita, Takaji ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

3C like protease; Catalytic triad; Norovirus; Serine protease; Serine like cysteine protease

Indexed keywords

ASPARTIC ACID; CARBOXYLIC ACID; CHYMOTRYPSIN; CYSTINE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; NUCLEOPHILE; PROTEINASE; SERINE; SERINE PROTEINASE;

ARTICLE; HYDROGEN BOND; IN VITRO STUDY; JAPANESE; MUTAGENESIS; MUTANT; MUTATION; NONHUMAN; NOROVIRUS; PROTEIN DEGRADATION; WILD TYPE;

CATALYSIS; CYSTEINE ENDOPEPTIDASES; GLUTAMIC ACID; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; MUTATION; NOROVIRUS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

NOROVIRUS;

EID: 57749187792     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn130     Document Type: Article

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