Autologous hematopoietic stem cell transplantation for type 1 diabetes

Annals of the New York Academy of Sciences

Volumn 1150, Issue , 2008, Pages 220-229

  Voltarelli, Júlio C ^a   Couri, Carlos E B ^a   Stracieri, Ana B P L ^a   Oliveira, Maria C ^a   Moraes, Daniela A ^a   Pieroni, Fabiano ^a   Barros, George M N ^a   Madeira, Maria Isabel A ^a   Malmegrim, Kelen C R ^a   Foss Freitas, Maria C ^a   Simões, Belinda P ^a   Foss, Milton C ^a   Squiers, Elizabeth ^b   Burt, Richard K ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Pacific Biodevelopment LLC   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

High dose immunosuppression; Stem cell transplantation; Type 1 diabetes

Indexed keywords

CYCLOPHOSPHAMIDE; THYMOCYTE ANTIBODY;

BRAZIL; CELL THERAPY; CLINICAL ARTICLE; CONFERENCE PAPER; DIABETIC KETOACIDOSIS; DRUG MEGADOSE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; RELAPSE;

EID: 57749175499     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1447.048     Document Type: Conference Paper

References (32)

1. Slavin, S. 1976. Treatment of life-threatening autoimmune diseases with myeloablative doses of immunosuppressive agents: experimental background and rationale for ABMT. Bone Marrow Transplant. 12 : 85 88.
2. Brodsky, R.A. et al. 1998. Immunablative high dose cyclophosphamide without stem cell rescue for refractory severe autoimmune disease. Ann. Intern. Med. 129 : 1031 1035.
3. Burt, R.K. et al. 2006. Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum 54 : 3750 3760.
4. Burt, R.K., S. Slavin, W.H. Burns & A.M. Marmont. 2002. Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood 99 : 768 784.
5. Moore, J., A. Tyndall & P. Brooks. 2001. Stem cells in the aetiopathogenesis and therapy of rheumatic diseases. Best Pract. Res. Clin. Rheumatol. 15 : 711 726.
6. Passweg, J. & A. Tyndall. 2007. Autologous stem cell transplantation in autoimmune diseases. Semin. Hematol. 44 : 278 285.
7. Burt, R.K. et al. 2008. Clinical applications of blood-derived and marrow-derived stem cells for non-malignant diseases. JAMA 299 : 925 936.
8. Muraro, P.A. et al. 2005. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med. 201 : 805 816.
9. de Kleer, I. et al. 2006. Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network. Blood 107 : 1696 1702.
10. Zhang, Y. 2002. In situ beta cell death promotes priming of diabetogenic CD8 T lymphocytes. J. Immunol. 168 : 1466 1472.
11. Atkinson, M.A. & E.H. Leiter. 1999. The NOD mouse model of type 1 diabetes: as good as it gets? Nature Med. 6 : 601 604.
12. Kang, E.M. et al. 2005. Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet regeneration once disease is established. Exp. Hematol. 33 : 699 705.
13. Staeva-Vieira, T., M. Peakman & M. von Herrath. 2007. Translational mini-review series on type 1 diabetes: immune-based therapeutic approaches for type 1 diabetes. Clin. Exp. Immunol. 148 : 17 31.
14. Couri, C.E.B. et al. 2008. Beta-cell regeneration to treat type 1 diabetes mellitus. Exp. Rev. Endocrinol. Metab. 3 : 51 60.
15. Eisenbarth, G.S. et al. 1985. Anti-tymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus. Diabetes Res. 2 : 271 276.
16. Keymeulen, B. et al. 2005. Insulin needs after CD3-antibody-therapy in new-onset type 1 diabetes. N. Engl. J. Med. 352 : 2598 2608.
17. Herold, K.C. et al. 2005. A single course of anti-CD3 monoclonal antibody hOKT3gamma 1 (Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54 : 1763 1769.
18. Nelson, J.L. et al. 1997. Pre-existing autoimmune disease in patients with long term survival after allogeneic bone marrow transplantation. J. Rheumatol. 24 (Suppl 48 23 29.
19. Lampeter, E.F., S.R. McCann & H. Kolb. 1998. Transfer of insulin-dependent diabetes by bone marrow transplantation. Lancet 351 : 568 569.
20. Domenick, M.A. & S. Ildstad. 2001. Impact of bone marrow transplantation on type I diabetes. World J. Surg. 25 : 474 480.
21. Burt, R.K. et al. 2002. Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis. Autoimmune. Rev. 1 : 133 138.
22. Voltarelli, J.C. et al. 2007. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 297 : 1568 76.
23. Malmegrim, K.C.R. et al. 2006. Mechanisms of action of autologous hematopoietic stem cell transplantation in type 1 diabetes patients. Revista Brasileira Hematol. Hemoter. 28 (Suppl 2 241.
24. Oliveira, G.L.V. et al. 2007. Downregulated expression of the bcl-xl and mci-1 antiapoptotic genes in type 1 diabetes patients after autologous hematopoietic stem cell transplantation. Presented at the 13th International Congress of Imunology, Rio de Janeiro, Brazil, August 21-25.
25. Skyler, J.S. 2007. Cellular therapy for type 1 diabetes. Has the time come? JAMA 297 : 1599 1600.
26. Ross, L.F. & L.H. Philipson. 2007. Ethics in hematopoietic stem cell transplantation in type 1 diabetes mellitus. JAMA 198 : 285.
27. Voltarelli et al. 2007. In reply. JAMA 298 : 285 286.
28. Chao, N. 2007. How sweet is it? The Hematologist 4 : 7.
29. Moore, J. et al. 2002. A pilot randomized trial comparing CD34-selected versus unmanipulated hematopoietic stem cell transplantation for severe, refractory rheumatoid arthritis. Arthritis Rheum. 46 : 2301 2309.
30. Fousteri, G., A. Hayek & M. von Herrath. 2007. Stopping diabetes in its track: autologous non-myeloablative stem cell-transplantation. Regen. Med. 2 : 845 851.
31. Sanders, J.E. 2004. Growth and development after hematopoietic cell transplantation. In Thomas' Hematopoietic Cell Transplantation. K.G. Blume et al., Eds. : 929 943. Blackwell Publishing. Malden, MA.
32. Wen, Y. et al. 2008. Reversal of new onset type 1 diabetes in mice by syngeneic bone marrow transplantation. Biochem. Biophys. Res. Commun. 374 : 282 287.