The pharmacology study of a new recombinant human VEGF receptor-Fc fusion protein on experimental choroidal neovascularization

Pharmaceutical Research

Volumn 26, Issue 1, 2009, Pages 204-210

  Zhang, Ming ^a   Yu, Dechao ^b   Yang, Chun ^b   Xia, Qingjie ^a   Li, Wang ^c   Liu, Bin ^c   Li, Hong ^b  

^a SICHUAN UNIVERSITY   (China)

^b Chengdu Kanghong Biotechnology Co Ltd   (China)

^c National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine   (China)

Author keywords

Age related macular degeneration; Antiangiogenesis; Choroidal neovascularization; Intravitreal injection; Vascular endothelial growth factor receptor

Indexed keywords

ANGIOGENESIS INHIBITOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; KH 902; RANIBIZUMAB; RECOMBINANT HUMAN VASCULOTROPIN RECEPTOR FC FUSION PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING ASSAY; CELL PROLIFERATION; CONJUNCTIVAL HEMORRHAGE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE EXAMINATION; EYE FUNDUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LASER; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MONKEY; NONHUMAN; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION; TISSUE DISTRIBUTION;

ANGIOGENESIS INHIBITORS; ANGIOGRAPHY; ANIMALS; AREA UNDER CURVE; CELL PROLIFERATION; CHOROID; CHOROIDAL NEOVASCULARIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE; FLUORESCEIN ANGIOGRAPHY; FUNCTIONAL LATERALITY; IMMUNOGLOBULIN FC FRAGMENTS; INJECTIONS; LIGANDS; MACACA MULATTA; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS;

EID: 57749174301     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9718-9     Document Type: Article

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