Mechanism of heart rate responses elicited by chemical stimulation of the hypothalamic paraventricular nucleus in the rat

Brain Research

Volumn 1248, Issue , 2009, Pages 115-126

  Kawabe, Tetsuya ^a   Chitravanshi, Vineet C ^a   Nakamura, Takeshi ^a   Kawabe, Kazumi ^a   Sapru, Hreday N ^a  

^a RWJ Barnabas Health   (United States)

Author keywords

Barodenervation; GABA receptor antagonist; Intrathecal injection; Ionotropic glutamate receptor antagonist; Microinjection; Vagotomy

Indexed keywords

CHEMICAL AGENT; N METHYL DEXTRO ASPARTIC ACID; OXYTOCIN RECEPTOR; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; HEART RATE; HYPOTHALAMUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SOLITARY TRACT NUCLEUS; SPINAL CORD; SYMPATHETIC TONE; TACHYCARDIA; THALAMUS MIDLINE NUCLEUS; VAGOTOMY;

ANIMALS; AUTONOMIC DENERVATION; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; HEART; HEART RATE; MALE; MICROINJECTIONS; N-METHYLASPARTATE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; RECEPTORS, GABA; RECEPTORS, GLUTAMATE; RECEPTORS, VASOPRESSIN; SOLITARY NUCLEUS; SPINAL CORD; SPINAL NERVES; STIMULATION, CHEMICAL; SYMPATHETIC NERVOUS SYSTEM; VAGOTOMY;

RATTUS; RATTUS NORVEGICUS;

EID: 57749173843     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.10.059     Document Type: Article

References (49)

1. Badoer E. Hypothalamic paraventricular nucleus and cardiovascular regulation. Clin. Exp. Pharmacol. Physiol. 28 (2001) 95-99
2. Boscan P., Kasparov S., and Paton J.F.R. Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex. Eur. J. Neurosci. 16 (2002) 907-920
3. Chen Q.H., Haywood J.R., and Toney G.M. Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors. Hypertension 42 (2003) 725-731
4. Coote J.H. The hypothalamus and cardiovascular regulation. In: Dun N.J., Machado B.H., and Pilowsky P.M. (Eds). Neural Mechanisms of Cardiovascular Regulation (2004), Kluwer Academic Publishers, Boston, MA, USA 117-146
5. Coote J.H., Yang Z., Pyner S., and Deering J. Control of sympathetic outflows by the hypothalamic paraventricular nucleus. Clin. Exp. Pharmacol. Physiol. 25 (1998) 461-463
6. Darlington D.N., Miyamoto M., Keil L.C., and Dallman M.F. Paraventricular stimulation with glutamate elicits bradycardia and pituitary responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 256 (1989) R112-R119
7. Dhruva A., Bhatnagar T., and Sapru H.N. Cardiovascular responses to microinjections of glutamate into the nTS of unanesthetized supracollicular decerebrate rats. Brain Res. 801 (1998) 88-100
8. Gordon F.J., and Sved A.F. Neurotransmitters in central cardiovascular regulation: glutamate and GABA. Clin. Exp. Pharmacol. Physiol. 29 (2002) 522-524
9. Gustafsson L.L., Post C., Edvardsen B., and Ramsay C.H. Distribution of morphine and meperidine after intrathecal administration in rat and mouse. Anesthesiology 63 (1985) 483-489
10. Guyenet P.G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 7 (2006) 335-346
11. Hardy S.G.P. Hypothalamic projections to cardiovascular centers of the medulla. Brain Res. 894 (2001) 233-240
12. Holstege G. Some anatomical observations on the projections from the hypothalamus to brainstem and spinal cord: an HRP and autoradiographic tracing study in the cat. J. Comp. Neurol. 260 (1987) 98-126
13. Izzo P.N., Sykes R.M., and Spyer K.M. Gamma-aminobutyric acid immunoreactive structures in the nucleus tractus solitarius: a light and electron microscopic study. Brain Res. 591 (1992) 69-78
14. Jia H.G., Wang B.R., Rao Z.R., Shi J.W., Shigemoto R., Kaneko T., and Mizuno N. GABAergic synapses upon neurons expressing substance P receptors in the nucleus of the solitary tract: an immunocytochemical electron microscope study in the rat. Neurosci. Lett. 210 (1996) 49-52
15. Kannan H., Niijima A., and Yamashita H. Effects of stimulation of the hypothalamic paraventricular nucleus on blood pressure and renal sympathetic nerve activity. Brain Res. Bull. 20 (1988) 779-783
16. Kannan H., Hayashida Y., and Yamashita H. Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am. J. Physiol. Regul. Interg. Comp. Physiol. 256 (1989) R1325-R1330
17. Kasamatsu K., Chitravanshi V.C., and Sapru H.N. Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (2004) R715-R728
18. Kawabe T., Chitravanshi V.C., Kawabe K., and Sapru H.N. Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat. Brain Res. 1102 (2006) 117-126
19. Kawabe T., Chitravanshi V.C., Kawabe K., and Sapru H.N. Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat. Neuroscience 153 (2008) 605-617
20. B receptors in the nucleus tractus solitarii. Clin. Exp. Hypertens. 17 (1995) 91-100
21. Li Y.F., Mayhan G.W., and Patel K.P. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H2328-H2336
22. Li Y.F., Jackson K.L., Stern J.E., Rabeler B., and Patel K.P. Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of hypothalamus. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H2847-H2856
23. Luiten P.G., Ter Horst G.J., Karst H., and Steffens A.B. The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res. 329 (1985) 374-378
24. Madden C.J., and Sved A.F. Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol. Neurobiol. 23 (2003) 739-749
25. Malpas S.C., and Coote J.H. Role of vasopressin in sympathetic response to paraventricular nucleus stimulation in anesthetized rats. Am. J. Physiol. Regul. Interg. Comp. Physiol. 266 (1994) R228-R236
26. Mendelowitz D. Advances in parasympathetic control of heart rate and cardiac function. News Physiol. Sci. 14 (1999) 155-161
27. 3H-morphine after intrathecal administration: relationship to analgesia. Anesth. Analg. 69 (1989) 323-327
28. Osborn J.W., and England S.K. Normalization of arterial pressure after barodenervation: role of pressure natriuresis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 259 (1990) R1172-R1180
29. Palkovits M. Interconnections between the neuroendocrine hypothalamus and the central autonomic system. Geoffrey Harris Memorial Lecture, Kitakyushu, Japan, October1998. Front. Neuroendocrinol. 20 (1999) 270-295
30. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press
31. Pickering A.E., Boscan P., and Paton J.F.R. Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii. J. Physiol. 551 (2003) 589-599
32. Pyner S., and Coote J.H. Identification of an efferent projection from the paraventricular nucleus of the hypothalamus terminating close to spinally projecting rostral ventrolateral medullary neurons. Neuroscience 88 (1999) 949-957
33. Pyner S., and Coote J.H. Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience 100 (2000) 549-556
34. Riphagen C.L., and Pittman Q.J. Spinal arginine vasopressin elevates renal nerve activity in the rat. J. Neuroendocrinol. 1 (1989) 339-344
35. Sapru H.N. Glutamate circuits in selected medullo-spinal areas regulating cardiovascular function. Clin. Exp. Pharmacol. Physiol. 29 (2002) 491-496
36. Sapru H.N. Neurotransmitters in the nucleus tractus solitarius mediating cardiovascular function. In: Dun N.J., Machado B.H., and Pilowsky P.M. (Eds). Neural Mechanisms of Cardiovascular Regulation (2004), Kluwer Academic Publishers, Boston, MA, USA 81-98
37. Schreihofer A.M., and Guyenet P.G. The baroreflex and beyond: control of sympathetic vasomotor tone by GABAergic neurons in the ventrolateral medulla. Clin. Exp. Pharmacol. Physiol. 29 (2002) 514-521
38. Stocker S.D., Simmons J.R., Stornetta R.L., Toney G.M., and Guyenet P.G. Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla. J. Comp. Neurol. 494 (2006) 673-685
39. Sundaram K., and Sapru H.N. NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory responses elicited from the ventrolateral medullary pressor area. Brain Res. 544 (1991) 33-41
40. Sundaram K., Murugaian J., and Sapru H.N. Cardiac responses to the microinjections of excitatory amino acids into the intermediolateral cell column of the rat spinal cord. Brain Res. 482 (1989) 12-22
41. Sved A.F. GABA mediated neural transmission in mechanisms of cardiovascular control by the NTS. In: Barraco I.R.A. (Ed). Nucleus of the Solitary Tract (1994), CRC Press, Boca Raton, FL, USA 245-253
42. Swanson L.W., and Sawchenko P.E. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu. Rev. Neurosci. 6 (1983) 269-324
43. Talman W.T., Granata A.R., and Reis D.J. Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control. Fed. Proc. 43 (1984) 39-44
44. Willette R.N., Krieger A.J., Barcas P.P., and Sapru H.N. Medullary GABA receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226 (1983) 893-899
45. Willette R.N., Barcas P.P., Krieger A.J., and Sapru H.N. Endogenous GABAergic mechanisms in the medulla and the regulation of blood pressure. J. Pharmacol. Exp. Ther. 230 (1984) 34-39
46. Yamashita H., Kannan H., Kasai M., and Osaka T. Decrease in blood pressure by stimulation of the rat hypothalamic paraventricular nucleus with l-glutamate or weak current. J. Auton. Nerv. Syst. 19 (1987) 229-234
47. Yang Z., and Coote J.H. Influence of the hypothalamic paraventricular nucleus on cardiovascular neurons in the rostral ventrolateral medulla of the rat. J. Physiol. 513 (1998) 521-530
48. Yang Z., Bertram D., and Coote J.H. The role of glutamate and vasopressin in the excitation of RVL neurones by paraventricular neurones. Brain Res. 908 (2001) 99-103
49. Yang Z., Wheatley M., and Coote J.H. Neuropeptides, amines and amino acids as mediators of the sympathetic effects of paraventricular nucleus activation in the rat. Exp. Physiol. 87.6 (2002) 663-674