Early immunologic responses to trauma in the emergency department patients with major injuries

Resuscitation

Volumn 80, Issue 1, 2009, Pages 83-88

  Yadav, Kabir ^a   Zehtabchi, Shahriar ^a   Nemes, Petru C ^a   Miller, Andrew C ^a   Azher, Mohammed ^a   Durkin, Helen ^a   Sinert, Richard ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Cytokines; Injury; Interleukins; Lymphocytes; Trauma

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD TRANSFUSION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HEMATOCRIT; HUMAN; IMMUNE RESPONSE; INJURY; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; BIOLOGICAL MARKERS; BLOOD CELL COUNT; CD4 LYMPHOCYTE COUNT; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INJURY SEVERITY SCORE; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-5; INTERLEUKIN-6; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; MONOCYTES; PROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 57649221486     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2008.09.012     Document Type: Article

References (30)

1. Kincaid E.H., Miller P.R., Meredith J.W., et al. Elevated arterial base deficit in trauma patients: a marker of impaired oxygen utilization. J Am Col Surg 187 (1998) 384-392
2. Aslar A.K., Kuzu M.A., Elhan A.H., et al. Admission lactate level and the APACHE II score are the most useful predictors of prognosis following torso trauma. Injury 35 (2004) 746-752
3. Lavery R.F., Livingston D.H., Tortella B.J., et al. The utility of venous lactate to triage injured patients in the trauma center. J Am Coll Surg 190 (2000) 656-664
4. Moore F.A., Sauaia A., Moore E.E., et al. Postinjury multiple organ failure: a bimodal phenomenon. J Trauma 40 (1996) 501-510
5. Skillman J.J., Bushnell L.S., Goldman H., et al. Respiratory failure, hypotension, sepsis, and jaundice. A clinical syndrome associated with lethal hemorrhage from acute stress ulceration of the stomach. Am J Surg 117 (1969) 523-530
6. Schinkel C., Faist E., Zimmer S., et al. Kinetics of circulating adhesion molecules and chemokines after mechanical trauma and burns. Eur J Surg 162 (1996) 763-768
7. Biffl W.L., Moore E.E., Moore F.A., et al. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?. Ann Surg 224 (1996) 647-664
8. Lyons A., Kelly J.L., Rodrick M.L., et al. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. Ann Surg 226 (1997) 450-458
9. Association for the Advancement of Automotive Medicine. The Abbreviated Injury Scale, 1990 Revision (1990), Association for the Advancement of Automotive Medicine, Des Plaines, IL
10. Mattox K.L., Feliciano D.V., and Moore E.E. Trauma. 4th ed. (1999), McGraw-Hill 87
11. Malone D.L., Dunne J., Tracy J.K., et al. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 54 (2003) 898-905
12. Paradis N.A., Balter S., Davison C.M., et al. Hematocrit as a predictor of significant injury after penetrating trauma. Am J Emerg Med 15 (1997) 224-228
13. Landwehr J.M., Pregibon D., and Shoemaker A.C. Graphical methods for assessing logistic regression models. J Am Stat Assoc 79 (1984) 61-71
14. Ditschkowski M., Kreuzfelder E., Majetschak M., et al. Reduced B cell HLA-DR expression and natural killer cell counts in patients prone to sepsis after injury. Eur J Surg 165 (1999) 1129-1133
15. Barkhausen T, Frerker C, Pütz C, et al. Depletion of nk cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response. Shock 2008;30:401-10.
16. Joshi P., Hauser C.J., Jones Q., et al. Mechanism of suppression of natural killer cell activity in trauma patients. Res Commun Mol Pathol Pharmacol 101 (1998) 241-248
17. Hauser C.J., Joshi P., Jones Q., et al. Suppression of natural killer cell activity in patients with fracture/soft tissue injury. Arch Surg 132 (1997) 1326-1330
18. Murdoch C., Muthana M., and Lewis C.E. Hypoxia regulates macrophage functions in inflammation. J Immunol 175 (2005) 6257-6263
19. De A.K., Laudanski K., and Miller-Graziano C.L. Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colony-stimulating factor-driven macrophage differentiation. J Immunol 170 (2003) 6355-6362
20. Cheadle W.G., Pemberton R.M., Robinson D., et al. Lymphocyte subset responses to trauma and sepsis. J Trauma 35 (1993) 844-849
21. O'Sullivan S.T., Lederer J.A., Horgan A.F., et al. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg 222 (1995) 482-490
22. Sperry J.L., Friese R.S., Frankel H.L., et al. Inflammation and the host response to injury investigators. Male gender is associated with excessive IL-6 expression following severe injury. J Trauma 64 (2008) 572-578
23. Donnelly T.J., Meade P., Jagels M., et al. Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. Crit Care Med 22 (1994) 768-776
24. Svoboda P., Kantorová I., and Ochmann J. Dynamics of interleukin 1, 2, and 6 and tumor necrosis factor alpha in multiple trauma patients. J Trauma 36 (1994) 336-340
25. MacConmara M.P., Maung A.A., Fujimi S., et al. Increased CD4+ CD25+ regulatory cell activity in trauma patients depresses protective Th1 immunity. Ann Surg 244 (2006) 514-523
26. Martin C., Boisson C., Haccoun M., et al. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25 (1997) 1813-1819
27. Rajasingh J., Bord E., Luedemann C., et al. IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J 20 (2006) 2112-2114
28. Mokart D., Capo C., Blache J.L., et al. Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer. Br J Surg 89 (2002) 1450-1456
29. Giannoudis P.V., Smith R.M., Perry S.L., et al. Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intensive Care Med 26 (2000) 1076-1081
30. Muehlstedt S.G., Lyte M., and Rodriguez J.L. Increased IL-10 production and HLA-DR suppression in the lungs of injured patients precede the development of nosocomial pneumonia. Shock 17 (2002) 443-450