Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 303-310

  Schott, Herbert ^a   Hamprecht, Klaus ^b   Schott, Sarah ^a   Schott, Timm C ^b   Schwendener, Reto A ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Antiviral drug resistance; Antiviral duplex drug; Herpes simplex virus (HSV); Human cytomegalovirus (HCMV); Hydrogenphosphonate method

Indexed keywords

ACICLOVIR; FOSCARNET; FOSCARNET SODIUM; GANCICLOVIR; GLYCEROL; LIPID; PHOSPHONIC ACID DERIVATIVE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG MIXTURE; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IC 50; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN;

ANTIVIRAL AGENTS; CROSS-LINKING REAGENTS; CYTOMEGALOVIRUS; DRUG INTERACTIONS; FOSCARNET; GLYCERYL ETHERS; HIV; HUMANS; INHIBITORY CONCENTRATION 50; SIMPLEXVIRUS; ZIDOVUDINE;

HUMAN HERPESVIRUS 5; SIMPLEXVIRUS;

EID: 57649195401     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.081     Document Type: Article

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