Over-expression of SOCS-3 Gene Promotes IL-10 Production by JEG-3 Trophoblast Cells

Placenta

Volumn 30, Issue 1, 2009, Pages 11-14

  Dong, Q ^a,b   Fan, R ^a   Zhao, S ^a   Wang, Y ^a  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

IL 10; IL 6; SOCS 3; Trophoblasts

Indexed keywords

GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; PLACENTA; PRIORITY JOURNAL; TROPHOBLAST;

CELL LINE, TUMOR; CHORIOCARCINOMA; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSFECTION; TROPHOBLASTS; UTERINE NEOPLASMS;

EID: 57649176602     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2008.10.008     Document Type: Article

References (21)

1. Diehl S., and Rincón M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 39 (2002) 531-536
2. Marine J.C., Topham D.J., McKay C., Wang D., Parganas E., Stravopodis D., et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98 (1999) 609-616
3. Alexander W.S., Starr R., Fenner J.E., Scott C.L., Handman E., Sprigg N.S., et al. Owczarek CM and others. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98 (1999) 597-608
4. Lang R., Pauleau A.L., Parganas E., Takahashi Y., Mages J., Ihle J.N., et al. SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol 4 (2003) 546-550
5. Qasimi P., Ming-Lum A., Ghanipour A., Ong C.J., Cox M.E., Ihle J., et al. Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages. J Biol Chem 281 (2006) 6316-6324
6. Roberts A.W., Robb L., Rakar S., Hartley L., Cluse L., Nicola N.A., et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A 98 (2001) 9324-9329
7. Waal Malefyt R., and Moore K.W. Interleukin-10. In: Thomson A. (Ed). The cytokine handbook. 3 edition (1998), Academic Press, San Diego 333-364
8. Chaouat G., Assal Meliani A., Martal J., Raghupathy R., Elliott J.F., Mosmann T., et al. IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol 154 (1995) 4261-4268
9. Fiorentino D.F., Zlotnik A., Vieira P., Mosmann T.R., Howard M., Moore K.W., et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146 (1991) 3444-3451
10. Hennessy A., Pilmore H.L., Simmons L.A., and Painter D.M. A deficiency of placental IL-10 in preeclampsia. J Immunol 163 (1999) 3491-3495
11. Rein D.T., Breidenbach M., Hönscheid B., Friebe-Hoffmann U., Engel H., Göhring U.J., et al. Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro. Cytokine 23 (2003) 119-125
12. Yang X.P., Schaper F., Teubner A., Lammert F., Heinrich P.C., Matern S., et al. Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo. J Hepatol 43 (2005) 704-710
13. Zhao S., Gu Y., Dong Q., Fan R., and Wang Y. Altered IL-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with preeclampsia. Placenta 29 (2008) 1024-1028
14. Mandl M., Ghaffari-Tabrizi N., Haas J., Nöhammer G., and Desoye G. Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines. Reproduction 132 (2006) 159-167
15. Serrano M.A., Macias R.I., Briz O., Monte M.J., Blazquez A.G., Williamson C., et al. Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta. Placenta 28 (2006) 107-117
16. Geiger T., Andus T., Klapproth J., Hirano T., Kishimoto T., and Heinrich P.C. Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol 18 (1988) 717-721
17. Ikebuchi K., Wong G.G., Clark S.C., Ihle J.N., Hirai Y., and Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci U S A 84 (1987) 9035-9039
18. Kühn R., Löhler J., Rennick D., Rajewsky K., and Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75 (1993) 263-274
19. Berg D.J., Kühn R., Rajewsky K., Müller W., Menon S., Davidson N., et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 96 (1995) 2339-2347
20. Robertson S.A., Care A.S., and Skinner R.J. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod 76 (2007) 738-748
21. Egwuagu C.E., Yu C.R., Zhang M., Mahdi R.M., Kim S.J., and Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol 168 (2002) 3181-3187