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Volumn 1148, Issue , 2008, Pages 269-281

Stress-induced alternative splicing modulations in brain and periphery: Acetylcholinesterase as a case study

Author keywords

Acetylcholinesterase; Alternative splicing; Neuro immune dialogue; Stress responses

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ENZYME VARIANT; MESSENGER RNA PRECURSOR;

EID: 57649174636     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1410.001     Document Type: Conference Paper
Times cited : (21)

References (94)
  • 1
    • 12344250822 scopus 로고    scopus 로고
    • Function of alternative splicing
    • Stamm, S. et al. 2005. Function of alternative splicing. Gene 344 : 1 20.
    • (2005) Gene , vol.344 , pp. 1-20
    • Stamm, S.1
  • 2
    • 33646847625 scopus 로고    scopus 로고
    • Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants
    • Ben-Ari, S. et al. 2006. Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants. J. Neurochem. 97 (Suppl 1 24 34.
    • (2006) J. Neurochem. , vol.97 , Issue.1 , pp. 24-34
    • Ben-Ari, S.1
  • 3
    • 0037718047 scopus 로고    scopus 로고
    • Pre-mRNA splicing modulations in senescence
    • &
    • Meshorer, E. & H. Soreq. 2002. Pre-mRNA splicing modulations in senescence. Aging Cell 1 : 10 16.
    • (2002) Aging Cell , vol.1 , pp. 10-16
    • Meshorer, E.1    Soreq, H.2
  • 4
    • 11144355172 scopus 로고    scopus 로고
    • Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in health, risk factors, exercise training, and genetics study
    • Sklan, E.H. et al. 2004. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in health, risk factors, exercise training, and genetics study. Proc. Natl. Acad. Sci. USA 101 : 5512 5517.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5512-5517
    • Sklan, E.H.1
  • 5
    • 33846227915 scopus 로고    scopus 로고
    • Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selection
    • Farchi, N. et al. 2007. Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selection. Eur. J. Neurosci. 25 : 87 98.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 87-98
    • Farchi, N.1
  • 6
    • 12244311203 scopus 로고    scopus 로고
    • Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology
    • &
    • Farchi, N., H. Soreq & B. Hochner. 2003. Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology. J. Physiol. 546 : 165 173.
    • (2003) J. Physiol. , vol.546 , pp. 165-173
    • Farchi, N.1    Soreq, H.2    Hochner, B.3
  • 7
    • 0035458728 scopus 로고    scopus 로고
    • Modified testicular expression of stress-associated " readthrough" acetylcholinesterase predicts male infertility
    • Mor, I. et al. 2001. Modified testicular expression of stress-associated "readthrough" acetylcholinesterase predicts male infertility. FASEB J. 15 : 2039 2041.
    • (2001) FASEB J. , vol.15 , pp. 2039-2041
    • Mor, I.1
  • 8
    • 17844375406 scopus 로고    scopus 로고
    • The influence of social hierarchy on primate health
    • Sapolsky, R.M. 2005. The influence of social hierarchy on primate health. Science 308 : 648 652.
    • (2005) Science , vol.308 , pp. 648-652
    • Sapolsky, R.M.1
  • 9
    • 0142053041 scopus 로고    scopus 로고
    • Stress and plasticity in the limbic system
    • Sapolsky, R.M. 2003. Stress and plasticity in the limbic system. Neurochem. Res. 28 : 1735 1742.
    • (2003) Neurochem. Res. , vol.28 , pp. 1735-1742
    • Sapolsky, R.M.1
  • 10
    • 0035828455 scopus 로고    scopus 로고
    • Usefulness and validity of post-traumatic stress disorder as a psychiatric category
    • &
    • Mezey, G. & I. Robbins. 2001. Usefulness and validity of post-traumatic stress disorder as a psychiatric category. BMJ 323 : 561 563.
    • (2001) BMJ , vol.323 , pp. 561-563
    • Mezey, G.1    Robbins, I.2
  • 11
    • 0029850424 scopus 로고    scopus 로고
    • Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response
    • Friedman, A. et al. 1996. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat. Med. 2 : 1382 1385.
    • (1996) Nat. Med. , vol.2 , pp. 1382-1385
    • Friedman, A.1
  • 12
    • 0032574973 scopus 로고    scopus 로고
    • Acute stress facilitates long-lasting changes in cholinergic gene expression
    • Kaufer, D. et al. 1998. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393 : 373 377.
    • (1998) Nature , vol.393 , pp. 373-377
    • Kaufer, D.1
  • 13
    • 0037127007 scopus 로고    scopus 로고
    • Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    • Meshorer, E. et al. 2002. Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science 295 : 508 512.
    • (2002) Science , vol.295 , pp. 508-512
    • Meshorer, E.1
  • 14
    • 33748898490 scopus 로고    scopus 로고
    • Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties
    • Sklan, E.H. et al. 2006. Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties. Biol. Psychiatry 60 : 741 751.
    • (2006) Biol. Psychiatry , vol.60 , pp. 741-751
    • Sklan, E.H.1
  • 15
    • 10744223484 scopus 로고    scopus 로고
    • Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation
    • Nijholt, I. et al. 2004. Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol. Psychiatry 9 : 174 183.
    • (2004) Mol. Psychiatry , vol.9 , pp. 174-183
    • Nijholt, I.1
  • 16
    • 33845675368 scopus 로고    scopus 로고
    • Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure
    • Browne, R.O. et al. 2006. Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure. FASEB J. 20 : 1733 1735.
    • (2006) FASEB J. , vol.20 , pp. 1733-1735
    • Browne, R.O.1
  • 17
    • 0027991322 scopus 로고
    • Population diversity and distinct haplotype frequencies associated with ACHE and BCHE genes of Israeli Jews from trans-Caucasian Georgia and from Europe
    • Ehrlich, G. et al. 1994. Population diversity and distinct haplotype frequencies associated with ACHE and BCHE genes of Israeli Jews from trans-Caucasian Georgia and from Europe. Genomics 22 : 288 295.
    • (1994) Genomics , vol.22 , pp. 288-295
    • Ehrlich, G.1
  • 18
    • 0034701812 scopus 로고    scopus 로고
    • A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases
    • Shapira, M. et al. 2000. A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases. Hum. Mol. Genet. 9 : 1273 1281.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1273-1281
    • Shapira, M.1
  • 19
    • 33645988822 scopus 로고    scopus 로고
    • Virtues and woes of AChE alternative splicing in stress-related neuropathologies
    • &
    • Meshorer, E. & H. Soreq. 2006. Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends Neurosci. 29 : 216 224.
    • (2006) Trends Neurosci. , vol.29 , pp. 216-224
    • Meshorer, E.1    Soreq, H.2
  • 20
    • 0035320772 scopus 로고    scopus 로고
    • Acetylcholinesterase - New roles for an old actor
    • &
    • Soreq, H. & S. Seidman. 2001. Acetylcholinesterase - new roles for an old actor. Nat. Rev. Neurosci. 2 : 294 302.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 294-302
    • Soreq, H.1    Seidman, S.2
  • 21
    • 0030873431 scopus 로고    scopus 로고
    • Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration
    • Andres, C. et al. 1997. Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration. Proc. Natl. Acad. Sci. USA 94 : 8173 8178.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8173-8178
    • Andres, C.1
  • 22
    • 0029360450 scopus 로고
    • Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice
    • Beeri, R. et al. 1995. Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice. Curr. Biol. 5 : 1063 1071.
    • (1995) Curr. Biol. , vol.5 , pp. 1063-1071
    • Beeri, R.1
  • 23
    • 34548490940 scopus 로고    scopus 로고
    • Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath
    • Evron, T. et al. 2007. Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB J. 21 : 2961 2969.
    • (2007) FASEB J. , vol.21 , pp. 2961-2969
    • Evron, T.1
  • 24
    • 34547111537 scopus 로고    scopus 로고
    • Translational control of recombinant human acetylcholinesterase accumulation in plants
    • Geyer, B.C. et al. 2007. Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC Biotechnol. 7 : 27.
    • (2007) BMC Biotechnol. , vol.7 , pp. 27
    • Geyer, B.C.1
  • 25
    • 57649142901 scopus 로고    scopus 로고
    • Long-term neuroprotection by butyrylcholinesterase and its C-terminal peptide confer in vitro suppression of amyloid fibril formation
    • In. B. Lukey, S.M. Somani. & J.A. Romano. Eds. CRC Press. Boca Rator.
    • Podoly, E. et al. 2007. Long-term neuroprotection by butyrylcholinesterase and its C-terminal peptide confer in vitro suppression of amyloid fibril formation. In Chemical Warfare Agents: Chemistry Pharmacology, Toxicology and Therapeutics, 2nd ed. B. Lukey, S.M. Somani & J.A. Romano Eds 203 218. CRC Press. Boca Rator.
    • (2007) Chemical Warfare Agents: Chemistry Pharmacology, Toxicology and Therapeutics, 2nd Ed. , pp. 203-218
    • Podoly, E.1
  • 26
    • 0037422539 scopus 로고    scopus 로고
    • Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    • Birikh, K.R. et al. 2003. Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. Proc. Natl. Acad. Sci. USA 100 : 283 288.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 283-288
    • Birikh, K.R.1
  • 27
    • 0037308205 scopus 로고    scopus 로고
    • The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
    • Brenner, T. et al. 2003. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB J. 17 : 214 222.
    • (2003) FASEB J. , vol.17 , pp. 214-222
    • Brenner, T.1
  • 28
    • 34249337343 scopus 로고    scopus 로고
    • Readthrough acetylcholinesterase in inflammation-associated neuropathies
    • Dori, A. et al. 2007. Readthrough acetylcholinesterase in inflammation-associated neuropathies. Life Sci. 80 : 2369 2374.
    • (2007) Life Sci. , vol.80 , pp. 2369-2374
    • Dori, A.1
  • 29
    • 34047267318 scopus 로고    scopus 로고
    • A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress
    • Kehat, R. et al. 2007. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest. Ophthalmol. Vis. Sci. 48 : 1290 1297.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 1290-1297
    • Kehat, R.1
  • 30
    • 57649142903 scopus 로고    scopus 로고
    • Treatment of human myasthenia with oral antisense suppression of acetylcholinesterase
    • Argov, Z. et al. 2007. Treatment of human myasthenia with oral antisense suppression of acetylcholinesterase. Neurology. 69 : 629 630.
    • (2007) Neurology. , vol.69 , pp. 629-630
    • Argov, Z.1
  • 31
    • 23244463063 scopus 로고    scopus 로고
    • The readthrough variant of acetylcholinesterase remains very minor after heat shock, organophosphate inhibition and stress, in cell culture and in vivo
    • Perrier, N.A. et al. 2005. The readthrough variant of acetylcholinesterase remains very minor after heat shock, organophosphate inhibition and stress, in cell culture and in vivo. J. Neurochem. 94 : 629 638.
    • (2005) J. Neurochem. , vol.94 , pp. 629-638
    • Perrier, N.A.1
  • 32
    • 3142755799 scopus 로고    scopus 로고
    • Combinatorial complexity of 5′ alternative acetylcholinesterase transcripts and protein products
    • Meshorer, E. et al. 2004. Combinatorial complexity of 5′ alternative acetylcholinesterase transcripts and protein products. J. Biol. Chem. 279 : 29740 29751.
    • (2004) J. Biol. Chem. , vol.279 , pp. 29740-29751
    • Meshorer, E.1
  • 33
    • 27544499653 scopus 로고    scopus 로고
    • SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    • Meshorer, E. et al. 2005. SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Mol. Psychiatry 10 : 985 997.
    • (2005) Mol. Psychiatry , vol.10 , pp. 985-997
    • Meshorer, E.1
  • 34
    • 20644448197 scopus 로고    scopus 로고
    • Chronic cholinergic imbalances promote brain diffusion and transport abnormalities
    • Meshorer, E. et al. 2005. Chronic cholinergic imbalances promote brain diffusion and transport abnormalities. FASEB J. 19 : 910 922.
    • (2005) FASEB J. , vol.19 , pp. 910-922
    • Meshorer, E.1
  • 35
    • 0037122918 scopus 로고    scopus 로고
    • PRiMA: The membrane anchor of acetylcholinesterase in the brain
    • &
    • Perrier, A.L., J. Massoulie & E. Krejci. 2002. PRiMA: the membrane anchor of acetylcholinesterase in the brain. Neuron 33 : 275 285.
    • (2002) Neuron , vol.33 , pp. 275-285
    • Perrier, A.L.1    Massoulie, J.2    Krejci, E.3
  • 36
    • 0022212796 scopus 로고
    • Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C
    • Futerman, A.H. et al. 1985. Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C. J. Neurochem. 45 : 1487 1494.
    • (1985) J. Neurochem. , vol.45 , pp. 1487-1494
    • Futerman, A.H.1
  • 37
    • 15244356627 scopus 로고    scopus 로고
    • Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development
    • Dori, A. et al. 2005. Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development. Cereb Cortex 15 : 419 430.
    • (2005) Cereb Cortex , vol.15 , pp. 419-430
    • Dori, A.1
  • 38
    • 0028365611 scopus 로고
    • Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins
    • Karpel, R. et al. 1994. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Exp. Cell Res. 210 : 268 277.
    • (1994) Exp. Cell Res. , vol.210 , pp. 268-277
    • Karpel, R.1
  • 39
    • 0030045560 scopus 로고    scopus 로고
    • Overexpression of alternative human acetylcholinesterase forms modulates process extensions in cultured glioma cells
    • Karpel, R. et al. 1996. Overexpression of alternative human acetylcholinesterase forms modulates process extensions in cultured glioma cells. J. Neurochem. 66 : 114 123.
    • (1996) J. Neurochem. , vol.66 , pp. 114-123
    • Karpel, R.1
  • 40
    • 34250726519 scopus 로고    scopus 로고
    • Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia
    • Perry, C. et al. 2007. Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia. Leukemia 21 : 1472 1480
    • (2007) Leukemia , vol.21 , pp. 1472-1480
    • Perry, C.1
  • 41
    • 0037028246 scopus 로고    scopus 로고
    • Complex regulation of acetylcholinesterase gene expression in human brain tumors
    • Perry, C. et al. 2002. Complex regulation of acetylcholinesterase gene expression in human brain tumors. Oncogene 21 : 8428 8441.
    • (2002) Oncogene , vol.21 , pp. 8428-8441
    • Perry, C.1
  • 42
    • 2442666424 scopus 로고    scopus 로고
    • CREB regulates AChE-R-induced proliferation of human glioblastoma cells
    • &
    • Perry, C., E.H. Sklan & H. Soreq. 2004. CREB regulates AChE-R-induced proliferation of human glioblastoma cells. Neoplasia 6 : 279 286.
    • (2004) Neoplasia , vol.6 , pp. 279-286
    • Perry, C.1    Sklan, E.H.2    Soreq, H.3
  • 43
    • 3242678754 scopus 로고    scopus 로고
    • From brain to blood: Alternative splicing evidence for the cholinergic basis of Mammalian stress responses
    • &
    • Pick, M., C. Flores-Flores & H. Soreq. 2004. From brain to blood: alternative splicing evidence for the cholinergic basis of Mammalian stress responses. Ann. N. Y. Acad. Sci. 1018 : 85 98.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1018 , pp. 85-98
    • Pick, M.1    Flores-Flores, C.2    Soreq, H.3
  • 44
    • 20044382046 scopus 로고    scopus 로고
    • Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities
    • Bryk, B. et al. 2005. Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. J. Neurochem. 92 : 1216 1227.
    • (2005) J. Neurochem. , vol.92 , pp. 1216-1227
    • Bryk, B.1
  • 45
    • 0033402485 scopus 로고    scopus 로고
    • Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms
    • &
    • Kaufer, D. & H. Soreq. 1999. Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms. Curr. Opin. Neurol. 12 : 739 743.
    • (1999) Curr. Opin. Neurol. , vol.12 , pp. 739-743
    • Kaufer, D.1    Soreq, H.2
  • 46
    • 0242708697 scopus 로고    scopus 로고
    • Expression of PRiMA in the mouse brain: Membrane anchoring and accumulation of 'tailed' acetylcholinesterase
    • Perrier, N.A. et al. 2003. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase. Eur. J. Neurosci. 18 : 1837 1847.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 1837-1847
    • Perrier, N.A.1
  • 47
    • 33646800553 scopus 로고    scopus 로고
    • Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats
    • Schwienbacher, I. et al. 2006. Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats. Neuroscience 140 : 769 778.
    • (2006) Neuroscience , vol.140 , pp. 769-778
    • Schwienbacher, I.1
  • 48
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
    • Chandrasekharan, N.V. et al. 2002. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl. Acad. Sci. USA 99 : 13926 13931.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13926-13931
    • Chandrasekharan, N.V.1
  • 49
    • 0030461557 scopus 로고    scopus 로고
    • Cholinergic drug resistance and impaired spatial learning in transgenic mice overexpressing human brain acetylcholinesterase
    • Andres, C. et al. 1996. Cholinergic drug resistance and impaired spatial learning in transgenic mice overexpressing human brain acetylcholinesterase. Prog. Brain Res. 109 : 265 272.
    • (1996) Prog. Brain Res. , vol.109 , pp. 265-272
    • Andres, C.1
  • 50
    • 0035048978 scopus 로고    scopus 로고
    • Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase
    • Erb, C. et al. 2001. Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. J. Neurochem. 77 : 638 646.
    • (2001) J. Neurochem. , vol.77 , pp. 638-646
    • Erb, C.1
  • 51
    • 0036386343 scopus 로고    scopus 로고
    • Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments
    • Cohen, O. et al. 2002. Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments. Mol. Psychiatry 7 : 874 885.
    • (2002) Mol. Psychiatry , vol.7 , pp. 874-885
    • Cohen, O.1
  • 52
    • 0036014116 scopus 로고    scopus 로고
    • Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase
    • Svedberg, M.M. et al. 2002. Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase. J. Mol. Neurosci. 18 : 211 222.
    • (2002) J. Mol. Neurosci. , vol.18 , pp. 211-222
    • Svedberg, M.M.1
  • 53
    • 15244356627 scopus 로고    scopus 로고
    • Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development
    • Dori, A. et al. 2005. Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development. Cereb Cortex 15 : 419 430.
    • (2005) Cereb Cortex , vol.15 , pp. 419-430
    • Dori, A.1
  • 54
    • 0034682493 scopus 로고    scopus 로고
    • Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates
    • Sternfeld, M. et al. 2000. Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates. Proc. Natl. Acad. Sci. USA 97 : 8647 8652.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8647-8652
    • Sternfeld, M.1
  • 55
    • 34248384448 scopus 로고    scopus 로고
    • The thymic theme of acetylcholinesterase splice variants in myasthenia gravis
    • Gilboa-Geffen, A. et al. 2007. The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood 109 : 4383 4391.
    • (2007) Blood , vol.109 , pp. 4383-4391
    • Gilboa-Geffen, A.1
  • 56
    • 0038618612 scopus 로고    scopus 로고
    • Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex
    • Rees, T. et al. 2003. Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol. Aging 24 : 777 787.
    • (2003) Neurobiol. Aging , vol.24 , pp. 777-787
    • Rees, T.1
  • 57
    • 22144436584 scopus 로고    scopus 로고
    • Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice
    • Rees, T.M. et al. 2005. Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Curr. Alzheimer. Res. 2 : 291 300.
    • (2005) Curr. Alzheimer. Res. , vol.2 , pp. 291-300
    • Rees, T.M.1
  • 58
    • 29644435705 scopus 로고    scopus 로고
    • Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses
    • Grisaru, D. et al. 2006. Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses. J Immunol. 176 : 27 35.
    • (2006) J Immunol. , vol.176 , pp. 27-35
    • Grisaru, D.1
  • 59
    • 20044362207 scopus 로고    scopus 로고
    • Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    • Benmoyal-Segal, L. et al. 2005. Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. FASEB J. 19 : 452 454.
    • (2005) FASEB J. , vol.19 , pp. 452-454
    • Benmoyal-Segal, L.1
  • 60
    • 11844283307 scopus 로고    scopus 로고
    • Anxiety and panic: From human studies to animal research and back
    • &
    • Battaglia, M. & A. Ogliari. 2005. Anxiety and panic: from human studies to animal research and back. Neurosci. Biobehav. Rev. 29 : 169 179.
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 169-179
    • Battaglia, M.1    Ogliari, A.2
  • 61
    • 3242707284 scopus 로고    scopus 로고
    • Blood-cell-specific acetylcholinesterase splice variations under changing stimuli
    • Pick, M. et al. 2004. Blood-cell-specific acetylcholinesterase splice variations under changing stimuli. Int. J. Dev. Neurosci. 22 : 523 531.
    • (2004) Int. J. Dev. Neurosci. , vol.22 , pp. 523-531
    • Pick, M.1
  • 63
    • 0030750402 scopus 로고    scopus 로고
    • Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons
    • Holmes, C. et al. 1997. Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons. J. Neurosci. Res. 49 : 207 218.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 207-218
    • Holmes, C.1
  • 64
    • 0023178782 scopus 로고
    • On-line visualization of dendritic release of acetylcholinesterase from mammalian substantia nigra neurons
    • &
    • Llinas, R.R. & S.A. Greenfield. 1987. On-line visualization of dendritic release of acetylcholinesterase from mammalian substantia nigra neurons. Proc. Natl. Acad. Sci. USA 84 : 3047 3050.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3047-3050
    • Llinas, R.R.1    Greenfield, S.A.2
  • 65
    • 0030657499 scopus 로고    scopus 로고
    • Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice
    • Beeri, R. et al. 1997. Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice. J. Neurochem. 69 : 2441 2451.
    • (1997) J. Neurochem. , vol.69 , pp. 2441-2451
    • Beeri, R.1
  • 66
    • 21844438972 scopus 로고    scopus 로고
    • Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    • Maskos, U. et al. 2005. Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436 : 103 107.
    • (2005) Nature , vol.436 , pp. 103-107
    • Maskos, U.1
  • 67
    • 0032486467 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors
    • von der Kammer, H. et al. 1998. Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors. J. Biol. Chem. 273 : 14538 14544.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14538-14544
    • Von Der Kammer, H.1
  • 68
    • 0033063505 scopus 로고    scopus 로고
    • Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission
    • Kaufer, D. et al. 1999. Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission. Chem. Biol. Interact. 119-120 : 349 360.
    • (1999) Chem. Biol. Interact. , vol.119-120 , pp. 349-360
    • Kaufer, D.1
  • 69
    • 5644244190 scopus 로고    scopus 로고
    • Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons
    • Dong, H. et al. 2004. Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons. J. Neurosci. 24 : 8950 8960.
    • (2004) J. Neurosci. , vol.24 , pp. 8950-8960
    • Dong, H.1
  • 70
    • 0141818332 scopus 로고    scopus 로고
    • Cholinergic function and Alzheimer's disease
    • Giacobini, E. 2003. Cholinergic function and Alzheimer's disease. Int. J. Geriatr. Psychiatry. 18 : S1 S5.
    • (2003) Int. J. Geriatr. Psychiatry. , vol.18
    • Giacobini, E.1
  • 71
    • 3242722725 scopus 로고    scopus 로고
    • Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase
    • Cohen, O. et al. 2003. Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase. J. Mol. Neurosci. 21 : 199 212.
    • (2003) J. Mol. Neurosci. , vol.21 , pp. 199-212
    • Cohen, O.1
  • 72
    • 66549119033 scopus 로고    scopus 로고
    • Acetylcholinesterase as a window onto stress responses
    • In. T. Steckler, N.H. Kalin. & J.M.H.M. Reul. Eds. Elsevier Science Amsterdam.
    • Soreq, H. et al. 2005. Acetylcholinesterase as a window onto stress responses. In Handbook on Stress in the Brain Part 1, Neuro biology and Stress, Vol. 1. T. Steckler, N.H. Kalin & J.M.H.M. Reul Eds 585 608. Elsevier Science Amsterdam.
    • (2005) Handbook on Stress in the Brain Part 1, Neuro Biology and Stress , vol.1 , pp. 585-608
    • Soreq, H.1
  • 73
    • 0036581331 scopus 로고    scopus 로고
    • Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: Implications for hippocampus-dependent learning
    • Blank, T. et al. 2002. Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning. J. Neurosci. 22 : 3788 3794.
    • (2002) J. Neurosci. , vol.22 , pp. 3788-3794
    • Blank, T.1
  • 74
    • 16344373908 scopus 로고    scopus 로고
    • Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression
    • &
    • Ben-Shaul, Y., H. Bergman & H. Soreq. 2005. Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression. Bioinformatics 21 : 1129 1137.
    • (2005) Bioinformatics , vol.21 , pp. 1129-1137
    • Ben-Shaul, Y.1    Bergman, H.2    Soreq, H.3
  • 75
    • 0032540337 scopus 로고    scopus 로고
    • Increased expression of acetylcholinesterase T and R transcripts during hematopoietic differentiation is accompanied by parallel elevations in the levels of their respective molecular forms
    • Chan, R.Y. et al. 1998. Increased expression of acetylcholinesterase T and R transcripts during hematopoietic differentiation is accompanied by parallel elevations in the levels of their respective molecular forms. J. Biol. Chem. 273 : 9727 9733.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9727-9733
    • Chan, R.Y.1
  • 76
    • 0036024019 scopus 로고    scopus 로고
    • Induction of acetylcholinesterase expression during apoptosis in various cell types
    • Zhang, X.J. et al. 2002. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ. 9 : 790 800.
    • (2002) Cell Death Differ. , vol.9 , pp. 790-800
    • Zhang, X.J.1
  • 77
    • 0036789955 scopus 로고    scopus 로고
    • The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34 (+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    • Deutsch, V.R. et al. 2002. The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34 (+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation. Exp. Hematol. 30 : 1153 1161.
    • (2002) Exp. Hematol. , vol.30 , pp. 1153-1161
    • Deutsch, V.R.1
  • 78
    • 0035260244 scopus 로고    scopus 로고
    • ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities
    • Grisaru, D. et al. 2001. ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities. Mol. Med. 7 : 93 105.
    • (2001) Mol. Med. , vol.7 , pp. 93-105
    • Grisaru, D.1
  • 79
    • 0036050866 scopus 로고    scopus 로고
    • Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library
    • Flores-Flores, C. et al. 2002. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. J. Neural. Transm. Suppl. 165 179.
    • (2002) J. Neural. Transm. Suppl. , pp. 165-179
    • Flores-Flores, C.1
  • 80
    • 35448939247 scopus 로고    scopus 로고
    • Cholinergic status modulations in human volunteers under acute inflammation
    • Ofek, K. et al. 2007. Cholinergic status modulations in human volunteers under acute inflammation. J. Mol. Med. 85 : 1239 1251.
    • (2007) J. Mol. Med. , vol.85 , pp. 1239-1251
    • Ofek, K.1
  • 81
    • 0034695178 scopus 로고    scopus 로고
    • Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    • Borovikova, L.V. et al. 2000. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton. Neurosci. 85 : 141 147.
    • (2000) Auton. Neurosci. , vol.85 , pp. 141-147
    • Borovikova, L.V.1
  • 82
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey, K.J. 2002. The inflammatory reflex. Nature 420 : 853 859.
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 83
    • 11144355227 scopus 로고    scopus 로고
    • Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors
    • Shytle, R.D. et al. 2004. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. J. Neurochem. 89 : 337 343.
    • (2004) J. Neurochem. , vol.89 , pp. 337-343
    • Shytle, R.D.1
  • 84
    • 0037461768 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    • Wang, H. et al. 2003. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 : 384 388.
    • (2003) Nature , vol.421 , pp. 384-388
    • Wang, H.1
  • 85
    • 0142178155 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: A missing link in neuroimmunomodulation
    • Pavlov, V.A. et al. 2003. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol. Med. 9 : 125 134.
    • (2003) Mol. Med. , vol.9 , pp. 125-134
    • Pavlov, V.A.1
  • 86
    • 18244401355 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
    • Pollak, Y. et al. 2005. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Ann. Neurol. 57 : 741 745.
    • (2005) Ann. Neurol. , vol.57 , pp. 741-745
    • Pollak, Y.1
  • 87
    • 23844441866 scopus 로고    scopus 로고
    • RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons
    • Evron, T. et al. 2005. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegenerative Dis. 2 : 16 27.
    • (2005) Neurodegenerative Dis. , vol.2 , pp. 16-27
    • Evron, T.1
  • 88
    • 23144441616 scopus 로고    scopus 로고
    • Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function
    • &
    • Kawashima, K. & T. Fujii. 2004. Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front Biosci. 9 : 2063 2085.
    • (2004) Front Biosci. , vol.9 , pp. 2063-2085
    • Kawashima, K.1    Fujii, T.2
  • 89
    • 0036848231 scopus 로고    scopus 로고
    • Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes
    • Tayebati, S.K. et al. 2002. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. J. Neuroimmunol. 132 : 147 155.
    • (2002) J. Neuroimmunol. , vol.132 , pp. 147-155
    • Tayebati, S.K.1
  • 90
    • 0020075929 scopus 로고
    • Acetylcholinesterase activity of lymphocytes: An enzyme characteristic of T-cells
    • &
    • Szelenyi, J.G., E. Bartha & S.R. Hollan. 1982. Acetylcholinesterase activity of lymphocytes: an enzyme characteristic of T-cells. Br. J. Haematol. 50 : 241 245.
    • (1982) Br. J. Haematol. , vol.50 , pp. 241-245
    • Szelenyi, J.G.1    Bartha, E.2    Hollan, S.R.3
  • 91
    • 33947621251 scopus 로고    scopus 로고
    • Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults
    • Evron, T. et al. 2007. Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults. Toxicology 233 : 97 107.
    • (2007) Toxicology , vol.233 , pp. 97-107
    • Evron, T.1
  • 92
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and inflammation
    • &
    • Hanada, T. & A. Yoshimura. 2002. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev. 13 : 413 421.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 413-421
    • Hanada, T.1    Yoshimura, A.2
  • 93
    • 0034161531 scopus 로고    scopus 로고
    • Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells
    • Kovanen, P.E. et al. 2000. Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells. Blood 95 : 1626 1632.
    • (2000) Blood , vol.95 , pp. 1626-1632
    • Kovanen, P.E.1
  • 94
    • 0032693784 scopus 로고    scopus 로고
    • Manipulations of ACHE gene expression suggest non-catalytic involvement of acetylcholinesterase in the functioning of mammalian photoreceptors but not in retinal degeneration
    • Broide, R.S. et al. 1999. Manipulations of ACHE gene expression suggest non-catalytic involvement of acetylcholinesterase in the functioning of mammalian photoreceptors but not in retinal degeneration. Brain. Res. Mol. Brain Res. 71 : 137 148.
    • (1999) Brain. Res. Mol. Brain Res. , vol.71 , pp. 137-148
    • Broide, R.S.1


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