Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library

Journal of Neural Transmission, Supplement

Volumn , Issue 62, 2002, Pages 165-179

  Flores Flores, C ^a   Nissim, A ^b,c   Shochat, S ^a   Soreq, H ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE SYNAPTIC PEPTIDE; CHOLINESTERASE INHIBITOR; MONOCLONAL ANTIBODY; PEPTIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; IMMUNOGLOBULIN FRAGMENT; PEPTIDE LIBRARY;

AGING; ALZHEIMER DISEASE; ANTIBODY LIBRARY; CARBOXY TERMINAL SEQUENCE; CHOLINERGIC SYNAPSE; CONFERENCE PAPER; DEMENTIA; DISSOCIATION CONSTANT; DRUG MECHANISM; HUMAN; HYDROLYSIS; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ARTICLE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; ENZYMOLOGY; IMMUNOLOGY; MOLECULAR GENETICS; PATHOPHYSIOLOGY; SYNAPSE;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; COMPLEMENTARITY DETERMINING REGIONS; DEMENTIA; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; SYNAPSES;

EID: 0036050866     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6139-5_16     Document Type: Conference Paper

References (44)

1. Alvarez A, Alarcon R, Opazo C, Campos EO, Munoz FJ, Calderon FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC (1998) Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci 18: 3213-3223
2. Adey NB, Kay BK (1997) Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin. Biochem J 324: 523-528
3. Andres C, Beeri R, Friedman A, Lev-Lehman E, Henis S, Timberg R, Shani M, Soreq H (1997) Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Iβ gene expression followed by late-onset neuromotor deterioration. Proc Natl Acad Sci USA 94: 8173-8178
4. Atherton E, Sheppard RC (1989) Solid phase peptide synthesis: a practical approach. IRL Press, Oxford
5. Beeri R, Andres C, Lev-Lehman E, Timberg R, Huberman T, Shani M, Soreq H (1995) Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice. Curr Biol 5: 1063-1071
6. Beeri R, Le Novere N, Mervis R, Huberman T, Grauer E, Changeux JP, Soreq H (1997) Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice. J Neurochem 69: 2441-2451
7. Bigbee JW, Sharma KV, Chan EL, Bogler O (2000) Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons. Brain Res 861: 354-362
8. Boschetti N, Brodbeck U, Jensen SP, Koch C, Norgaard-Pedersen B (1996) Monoclonal antibodies against a C-terminal peptide of human brain acetylcholinesterase distinguish between erythrocyte and brain acetylcholinesterases. Clin Chem 42: 19-23
9. Chothia C, Lesk AM (1987) Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol 196: 901-917
10. Coyle JT, Price DL, DeLong MR (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219: 1184-1190
11. de Kruif J, Boel E, Logtenberg T (1995) Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions. J Mol Biol 248: 97-105
12. Darboux I, Barthalay Y, Piovant M, Hipeau-Jacquotte R (1996) The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties. EMBO J 15: 4835-4843
13. Friedman A, Kaufer D, Shemer J, Hendler I, Soreq H, Tur-Kaspa I (1996) Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat Med 2: 1382-1385
14. Futerman AH, Low MG, Michaelson DM, Silman I (1985) Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C. J Neurochem 45: 1487-1494
15. Griffiths AD, Malmqvist M, Marks JD, Bye JM, Embleton MJ, McCafferty J, Baier M, Holliger KP, Gorick BD, Hughes-Jones NC, Hoogenboom HR, Winter G (1993) Human anti-self antibodies with high specificity from phage display libraries. EMBO J 12: 725-734
16. Grifman M, Galyam N, Seidman S, Soreq H (1998) Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis. Proc Natl Acad Sci USA 95: 13935-13940
17. Grisaru D, Sternfeld M, Eldor A, Glick D, Soreq H (1999) Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem 264: 672-686
18. Grisaru D, Deutsch V, Shapira M, Pick M, Sternfeld M, Melamed-Book N, Kaufer D, Galyam N, Gait MJ, Owen D, Lessing JB, Eldor A, Soreq H (2001) ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities. Mol Med 7: 93-105
19. Harrinson JL, Williams SC, Winter G, Nissim A (1996) Screening of phage antibody libraries. Meth Enzymol 267: 83-109
20. Henderikx P, Kandilogiannaki M, Petrarca C, von Mensdorff-Pouilly S, Hilgers JHM, Krambovitis E, Arends J, Hoogenboom HR (1998) Human single-chain Fv antibodies to MUC1 core peptide selected from phage display libraries recognize unique epitopes and predominantly bind adenocarcinoma. Cancer Res 58: 4324-4332
21. Hoogenboom HR, Lutgerink JT, Pelsers MM, Rousch MJ, Coote J, van Neer N, De Bruine A, Van Nieuwenhoven FA, Glatz JF, Arends JW (1999) Selection-dominant and nonaccessible epitopes on cell-surface receptors revealed by cell-panning with a large phage antibody library. Eur J Biochem 260: 774-784
22. Karpel R, Ben Aziz-Aloya R, Sternfeld M, Ehrlich G, Ginzberg D, Tarroni P, Clementi F, Zakut H, Soreq H (1994) Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Exp Cell Res 210: 268-277
23. Kaufer D, Friedman A, Seidman S, Soreq H (1998) Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393: 373-377
24. Kristensen P, Winter G (1998) Proteolytic selection for protein folding using filamentous bacteriophages. Fold Des 3: 321-328
25. Layer PG, Willbold E (1995) Novel functions of cholinesterases in development, physiology and disease. Prog Histochem Cytochem 29: 1-94
26. Lofas S, Johnsson B (1990) A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands. J Chem Soc Chem Commun 21: 1526-1528
27. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, Winter G (1991) By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 222: 581-597
28. Marks JD, Griffiths AD, Malmqvist M, Clackson TP, Bye JM, Winter G (1992) By-passing immunization: building high affinity human antibodies by chain shuffling. Biotechnology 10: 779-783
29. Munro S, Pelham HR (1986) An Hsp70-like protein in the ER: identity with the 78kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell 46: 291-300
30. Neri D, Carnemolla B, Nissim A, Leprini A, Querze G, Balza E, Pini A, Tarli L, Halin C, Neri P, Zardi L, Winter G (1997) Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. Nat Biotechnol 15: 1271-1275
31. Nissim A, Hoogenboom HR, Tomlinson IM, Flynn G, Midgley C, Lane D, Winter G (1994) Antibody fragments from a "single pot" phage display library as immunochemical reagents. EMBO J 13: 692-698
32. Nordberg A, Hellstrom-Lindahl E, Almkvist O, Meurling L (1999) Activity of acetylcholinesterase in CSF increases in Alzheimer's patients after treatment with tacrine. Alzheimer's Reports 2: 347-352
33. Persic L, Horn IR, Rybak S, Cattaneo A, Hoogenboom HR, Bradbury A (1999) Single-chain variable fragments selected on the 57-76 p21Ras neutralising epitope from phage antibody libraries recognise the parental protein. FEBS Lett 443: 112-116
34. Roden LD, Myzka D (1996) Global analysis of a macromolecular interaction measured on BIAcore. Biochem Biophys Res Commu 225: 1073-1077
35. Schneider LS (2001) Treatment of Alzheimer's disease with cholinesterase inhibitors. Clin Geriatr Med 17: 337-358
36. Soreq H, Glick D (2000) Novel roles for cholinesterases in stress and inhibitor responses. In: Giacobini E (ed) Cholinesterases and cholinesterase inhibitors: basic, preclinical and clinical aspects. Martin Dunitz, London, pp 47-61
37. Soreq H, Seidman S (2001) Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci 2: 294-302
38. Sternfeld M, Ming G, Song H, Sela K, Timberg R, Poo M, Soreq H (1998) Acetylcholinesterase enhances neurite growth and synapse development through alternative contributions of its hydrolytic capacity, core protein, and variable C termini. J Neurosci 18: 1240-1249
39. Sternfeld M, Shoham S, Klein O, Flores-Flores C, Evron T, Idelson GH, Kitsberg D, Patrick JW, Soreq H (2000) Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates. Proc Natl Acad Sci USA 97: 8647-8652
40. Tainer JA, Getzoff ED, Alexander H, Houghten RA, Olson AJ, Lerner RA, Hendrickson WA (1984) The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature 312: 127-134
41. Thornton JM, Edwards MS, Taylor WR, Barlow DJ (1986) Location of "continuous" antigenic determinants in the protruding regions of proteins. EMBO J 5: 409-413
42. H segments with different hypervariable loops. J Mol Biol 227: 776-798
43. Vaughan TJ, Williams AJ, Pritchard K, Osbourn JK, Pope AR, Earnshaw JC, McCafferty J, Hodits RA, Wilton J, Johnson KS (1996) Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat Biotechnol 14: 309-314
44. Wright CI, Geula C, Mesulam MM (1993) Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Ann Neurol 34: 373-384