Gene targeting demonstrates that inducible nitric oxide synthase is not essential for resistance to oral candidiasis in mice, or for killing of Candida albicans by macrophages in vitro

Oral Microbiology and Immunology

Volumn 24, Issue 1, 2009, Pages 83-88

  Farah, C S ^a   Saunus, J M ^a   Hu, Y ^a   Kazoullis, A ^a   Ashman, R B ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Candida albicans; Innate immunity; INOS; Oral candidiasis; Oral infection

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; EFFECTOR CELL; GENE TARGETING; INFECTION RESISTANCE; INFECTION SENSITIVITY; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; TH1 CELL; THRUSH;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS, ORAL; CYTOKINES; GENE TARGETING; ISOENZYMES; MACROPHAGES; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS;

EID: 57649170968     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2008.00462.x     Document Type: Article

References (34)

1. Balish E, Filutowicz H, Oberley TD. Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun 1990 : 58 : 107 113.
2. Balish E, Warner TF, Nicholas PJ, Paulling EE, Westwater C, Schofield DA. Susceptibility of germfree phagocyte oxidase- and nitric oxide synthase 2-deficient mice, defective in the production of reactive metabolites of both oxygen and nitrogen, to mucosal and systemic candidiasis of endogenous origin. Infect Immun 2005 : 73 : 1313 1320.
3. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 : 441 : 235 238.
4. Beutler B. TLR4 as the mammalian endotoxin sensor. Curr Top Microbiol Immunol 2002 : 270 : 109 120.
5. Bogdan C The function of nitric oxide in the immune system. In : Mayer B, ed. Handbook of experimental pharmacology. Berlin, New York : Springer, 2000 : 443 492.
6. Bogdan C, Rollinghoff M, Diefenbach A. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr Opin Immunol 2000 : 12 : 64 76.
7. Chakir J, Cote L, Coulombe C, Deslauriers N. Differential pattern of infection and immune response during experimental oral candidiasis in BALB/c and DBA/2 (H-2d) mice. Oral Microbiol Immunol 1994 : 9 : 88 94.
8. Challacombe S, Rahman D, Mistry M, Naglik J. Humoral factors in the protection of the oral cavity against candidiasis. In : Fidel P, Huffnagle G, ed. Fungal immunology: from an organ perspective. Berlin, New York : Springer, 2005 : 37 57.
9. Dongari-Bagtzoglou A. Innate defense mechanisms in oral candidiasis. In : Fidel P, Huffnagle G ed. Fungal immunology: from an organ perspective. Berlin, New York : Springer, 2005 : 13 35.
10. Elahi S, Pang G, Ashman RB, Clancy R. Nitric oxide-enhanced resistance to oral candidiasis. Immunology 2001 : 104 : 447 454.
11. Elahi S, Pang G, Clancy R, Ashman RB. Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis. Infect Immun 2000 : 68 : 5771 5777.
12. Farah CS, Ashman RB. Active and passive immunization against oral Candida albicans infection in a murine model. Oral Microbiol Immunol 2005 : 20 : 376 381.
13. Farah CS, Ashman RB, Challacombe SJ. Oral candidosis. Clin Dermatol 2000 : 18 : 553 562.
14. Farah CS, Elahi S, Drysdale K et al. Primary role for CD4(+) T lymphocytes in recovery from oropharyngeal candidiasis. Infect Immun 2002 : 70 : 724 731.
15. Farah CS, Elahi S, Pang G et al. T cells augment monocyte and neutrophil function in host resistance against oropharyngeal candidiasis. Infect Immun 2001 : 69 : 6110 6118.
16. Farah CS, Gotjamanos T, Seymour GJ, Ashman RB. Cytokines in the oral mucosa of mice infected with Candida albicans. Oral Microbiol Immunol 2003 : 17 : 375 378.
17. Farah CS, Hong S, Wanasaengsakul S et al. Irradiation-induced oral candidiasis in an experimental murine model. Oral Microbiol Immunol 2001 : 16 : 358 363.
18. Farah CS, Hu Y, Riminton S, Ashman RB. Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting. Oral Microbiol Immunol 2006 : 21 : 252 255.
19. Fierro IM, Barja-Fidalgo C, Cunha FQ, Ferreira SH. The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils. Immunology 1996 : 89 : 295 300.
20. Filler SG. Candida-host cell receptor-ligand interactions. Curr Opin Microbiol 2006 : 9 : 333 339.
21. Hu Y, Farah CS, Ashman RB. Effector function of leucocytes from susceptible and resistant mice against distinct isolates of Candida albicans. Immunol Cell Biol 2006 : 84 : 455 460.
22. Huang FP, Niedbala W, Wei XQ et al. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 1998 : 28 : 4062 4070.
23. Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007 : 25 : 221 242.
24. MacMicking JD, Nathan C, Hom G et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995 : 81 : 641 650.
25. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006 : 441 : 231 234.
26. Miljkovic D, Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev 2004 : 15 : 21 32.
27. Murray HW, Nathan CF. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med 1999 : 189 : 741 746.
28. Pfaller MA. Epidemiology of candidiasis. J Hosp Infect 1995 : 30 : 329 338.
29. Romani L. Immunity to fungal infections. Nat Rev Immunol 2004 : 4 : 1 23.
30. Saresella M, Roda K, Speciale L et al. A rapid evaluation of phagocytosis and killing of Candida albicans by CD13+ leukocytes. J Immunol Methods 1997 : 210 : 227 234.
31. Scully C, el-Kabir M, Samaranayake LP. Candida and oral candidosis: a review. Crit Rev Oral Biol Med 1994 : 5 : 125 157.
32. Ueno Y, Fukumatsu M, Ogasawara A, Watanabe T, Mikami T, Matsumoto T. Hyphae formation of Candida albicans is regulated by polyamines. Biol Pharm Bull 2004 : 27 : 890 892.
33. Vazquez-Torres A, Balish E. Macrophages in resistance to candidiasis. Microbiol Mol Biol Rev 1997 : 61 : 170 192.
34. Vazquez-Torres A, Jones-Carson J, Balish E. Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages. Infect Immun 1996 : 64 : 3127 3133.