Apolipoprotein(a), through its strong lysine-binding site in KIV 10, mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway

Journal of Biological Chemistry

Volumn 283, Issue 45, 2008, Pages 30503-30512

  Cho, Taewoo ^a   Jung, Yoojin ^a   Koschinsky, Marlys L ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b Heart and Stroke Foundation of Ontario

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BLOOD VESSEL PROSTHESES; CAPILLARITY; CHEMICAL REACTIONS; LIQUIDS; PHOSPHORYLATION; PIGMENTS; SELF ASSEMBLY; SHRINKAGE;

ACTIN CYTOSKELETON; APOLIPOPROTEIN; ATHEROGENESIS; CELL CONTRACTIONS; DO-MAINS; ENDOTHELIAL BARRIERS; ENDOTHELIAL DYSFUNCTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; KINASE INHIBITORS; LYSINEBINDING SITES; MLC PHOSPHORYLATIONS; MOLECULAR BASES; MYOSIN LIGHT CHAINS; PHOSPHATASE ACTIVITIES; PROTEIN COMPONENTS; RISK FACTORS; SIGNALING PATHWAYS; STRESS FIBER FORMATIONS;

ENDOTHELIAL CELLS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMINOCAPROIC ACID; APOLIPOPROTEIN A; LYSINE; MYOSIN LIGHT CHAIN; MYPT 1 PROTEIN; PHOSPHATASE; PROTEIN; RHO FACTOR; RHO KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EMBRYO; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KRINGLE DOMAIN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS FIBER;

6-AMINOCAPROIC ACID; ACTINS; AMIDES; ANTIFIBRINOLYTIC AGENTS; APOLIPOPROTEINS A; ATHEROSCLEROSIS; BINDING SITES; CAPILLARY PERMEABILITY; CELL LINE; CYTOSKELETON; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; LYSINE; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; PLASMINOGEN; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 57649155195     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802648200     Document Type: Article

References (46)

1. Koschinsky, M. L. (2006) Cardiovasc. Hematol. Disord. Drug Targets 6, 267-278
2. Anuurad, E., Boffa, M. B., Koschinsky, M. L., and Berglund, L. (2006) Clin. Lab. Med. 26, 751-772
3. Koschinsky, M. L., Côté, G. P., Gabel, B., and van der Hoek, Y. Y. (1993) J. Biol. Chem. 268, 19819-19825
4. McLean, J. W., Tomlinson, J. E., Kuang, W., Eaton, D. L., Chen, E., Fless, G., Scanu, A., and Lawn, R. M. (1987) Nature 330, 132-137
5. Gabel, B. R., and Koschinsky, M. L. (1995) Biochemistry 34, 15777-15784
6. van der Hoek, Y. Y., Wittekoek, M. E., Beisiegel, U., Kastelein, J. J. P., and Koschinsky, M. L. (1993) Hum. Mol. Genet. 2, 361-366
7. Lackner, D., Cohen, J. C., and Hobbs, H. H. (1993) Hum. Mol. Genet. 2, 933-940
8. Becker, L., McLeod, R. S., Marcovina, S. M., Yao, Z., and Koschinsky, M. L. (2001) J. Biol. Chem. 276, 36155-36162
9. Sangrar, W., and Koschinsky, M. L. (2000) Biochem. Cell Biol. 78, 519-525
10. Hughes, S. D., Lou, X. J., Ighani, S., Verstuyft, J., Grainger, D. J., Lawn, R. M., and Rubin, E. M. (1997) J. Clin. Invest. 100, 1493-1500
11. Michel, C. C., and Curry, F. E. (1999) Physiol. Rev. 79, 703-761
12. Schnittler, H. J., Wilke, A., Gress, T., Suttorp, N., and Drenckhahn, D. (1990) J. Physiol. 431, 379-401
13. Goeckeler, Z. M., and Wysolmerski, R. B. (1995) J. Cell Biol. 130, 613-627
14. Bodmer, J. E., Van Engelenhoven, J., Reyes, G., Blackwell, K., Kamath, A., Shasby, D. M., and Moy, A. B. (1997) Microvasc. Res. 53, 261-271
15. Gündüz, D., Hirche, F., Härtel, F. V., Rodewald, C. W., Schäfer, M., Pfitzer, G., Piper, H. M., and Noll, T. (2003) Cardiovasc. Res. 59, 470-478
16. Wojciak-Stothard, B., Entwistle, A., Garg, R., and Ridley, A. J. (1998) J. Cell. Physiol. 176, 150-165
17. Lum, H., Ashner, J. L., Phillips, P. G., Fletcher, P. W., and Malik, A. B. (1992) Am. J. Physiol. 263, L219-L225
18. Essler, M., Retzer, M., Bauer, M., Heemsker, J. W., Aepfelbacher, M., and Seiss, W. (1999) J. Biol. Chem. 274, 30361-30364
19. Pellegrino, M., Furmaniak-Kazmierczak, E., LeBlanc, J. C., Cho, T., Cao, K., Marcovina, S. M., Boffa, M. B., Côté, G. P., and Koschinsky, M. L. (2004) J. Biol. Chem. 279, 6526-6533
20. Garcia, J. G. N., Davis, H. W., and Patterson, C. E. (1995) J. Cell. Physiol. 163, 510-522
21. Van Nieuw Amerongen, G. P., Draijer, R., Vermeer, M. A., and van Hinsbergh, V. W. M. (1998) Circ. Res. 83, 1115-1123
22. Somlyo, A. P., and Somlyo, A. V. (2000) J. Physiol. 522, 177-185
23. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 273, 245-248
24. Essler, M., Amano, M., Kruse, H. J., Kaibuchi, K., Weber, P. C., and Aepfelbacher, M. (1998) J. Biol. Chem. 273, 21867-21874
25. Koschinsky, M. L., Tomlinson, J. E., Zioncheck, T. F., Schwartz, K., Eaton, D. L., and Lawn, R. M. (1991) Biochemistry 30, 5044-5051
26. Sangrar, W., Gabel, B. R., Boffa, M. B., Walker, J. B., Hancock, M. A., Marcovina, S. M., Horrevoets, A. J. G., Nesheim, M. E., and Koschinsky, M. L. (1997) Biochemistry 36, 10353-10363
27. Becker, L., Cook, P. M., and Koschinsky, M. L. (2004) Biochemistry 43, 9978-9988
28. Kawano, Y., Fukata, Y., Oshiro, N., Amano, M., Nakamura, T., Ito, M., Matsumura, F., Inagaki, M., and Kaibuchi, K. (1999) J. Cell Biol. 147, 1023-1038
29. Marcovina, S. M., Koschinsky, M. L., Albers, J. J., and Skarlatos, S. (2003) Clin. Chem. 49, 1785-1796
30. Angelin, B. (1997) Curr. Opin. Lipidol. 8, 337-341
31. Boonmark, N. W., Lou, X. J., Yang, Z. J., Schwartz, K., Zhang, J. L., Rubin, E. M., and Lawn, R. M. (1997) J. Clin. Invest. 100, 558-564
32. Allen, S., Khan, S., Tam, S., Koschinsky, M. L., Taylor, P., and Yacoub, M. (1998) FASEB J. 12, 1765-1766
33. Takami, S., Yamashita, S., Kihara, S., Ishigami, M., Takemura, K., Kume, N., Kita, T., and Matsuzawa, Y. (1998) Circulation 97, 721-728
34. Zhao, S. P., and Xu, D. Y. (2000) Thromb. Res. 100, 501-510
35. Haque, N. S., Zhang, X., French, D. L., Li, J., Poon, M., Fallon, J. T., Gabel, B. R., Taubman, M. B., Koschinsky, M. L., and Harpel, P. C. (2000) Circulation 102, 786-792
36. Sorensen, K. E., Celermajer, D. S., Georgakopoulos, D., Hatcher, G., Betteridge, D. J., and Deanfield, J. E. (1994) J. Clin. Invest. 93, 50-55
37. Tsurumi, Y., Nagashima, H., Ichikawa, K., Sumiyoshi, T., and Hosoda, S. (1995) J. Am. Coll. Cardiol. 26, 1242-1250
38. Schachinger, V., Halle, M., Minners, J., Berg, A., and Zeiher, A. M. (1997) J. Am. Coll. Cardiol. 30, 927-934
39. Hancock, M. A., Boffa, M. B., Marcovina, S. M., Nesheim, M. E., and Koschinsky, M. L. (2003) J. Biol. Chem. 278, 23260-23269
40. Belczewski, A. R., Ho, J., Taylor, F. B., Jr., Boffa, M. B., Jia, Z., and Koschinsky, M. L. (2005) Biochemistry 44, 555-564
41. Redlitz, A., and Plow, E. F. (1995) Baillieres Clin. Haematol. 8, 313-327
42. Kwon, M., MacLeod, T. J., Zhang, Y., and Waisman, D. M. (2005) Front. Biosci. 10, 300-325
43. Babbin, B. A., Parkos, C. A., Mandell, K. J., Winfree, L. M., Laur, O., Ivanov, A. I., and Nusrat, A. (2007) Am. J. Pathol. 170, 951-966
44. Guan, J. L. (2004) Science 303, 773-774
45. del Pozo, M. A., Alderson, N. B., Kiosses, W. B., Chiang, H. H., Anderson, R. G., and Schwartz, M. A. (2004) Science 303, 839-842
46. Palazzo, A. F., Eng, C. H., Schlaepfer, D. D., Marcantonio, E. E., and Gundersen, G. G. (2004) Science 303, 836-839