Genetics of susceptibility to malaria related phenotypes

Infection, Genetics and Evolution

Volumn 9, Issue 1, 2009, Pages 97-103

  Carpenter, Danielle ^a   Rooth, Ingegerd ^b   Färnert, Anna ^c   Abushama, Hind ^a   Quinnell, Rupert J ^a   Shaw, Marie Anne ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Association; Clinical episodes; Parasite density; Plasmodium falciparum; TDT; TNF

Indexed keywords

HLA DQA1 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR;

ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALARIA; NONHUMAN; PEDIGREE ANALYSIS; PHENOTYPE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TANZANIA; VARIABLE NUMBER OF TANDEM REPEAT;

ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DATA INTERPRETATION, STATISTICAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA-D ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-10; INTERLEUKINS; LINKAGE DISEQUILIBRIUM; LONGITUDINAL STUDIES; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PARASITEMIA; PEDIGREE; PHENOTYPE; POLYMORPHISM, GENETIC; TANZANIA; TUMOR NECROSIS FACTOR-ALPHA;

PLASMODIUM FALCIPARUM;

EID: 57649138656     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meegid.2008.10.008     Document Type: Article

References (44)

1. Abecasis G.R., Cardon L.R., and Cookson W.O.C. A general test of association for quantitative traits in nuclear families. Am. J. Hum. Genet. 66 (2000) 279-292
2. Abel L., Cot M., Mulder L., Carnevale P., and Feingold J. Segregation analysis detects a major gene controlling blood infection levels in human malaria. Am. J. Hum. Genet. 50 (1993) 1308-1317
3. Aidoo M., McElroy P.D., Kolczak M.S., Terlouw D.J., ter Kuile F.O., Nahlen B., Lal A.A., and Udhayakumar V. Tumour necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in Western Kenya. Genet. Epidemiol. 21 (2001) 201-211
4. Bennett S., Allen S.J., Olerup O., Jackson D.J., Wheeler J.G., Rowe P.A., Riley E.M., and Greenwood B.M. Human leukocyte antigen (HLA) and malaria morbidity in a Gambian community. Trans. R. Soc. Trop. Med. Hyg. 87 (1993) 286-287
5. Bereczky S., Liljander A., Rooth I., Faraja L., Granath F., Montgomery S.M., and Farnett A. Multiclonal asymptomatic Plasmodium falciparum infections predict a reduced risk of malaria disease in a Tanzanian population. Microb. Infect. 9 (2007) 103-110
6. Blangero J., and Almasy L. Multipoint oligogenic linkage analysis of quantitative traits. Genet. Epidemiol. 14 (1997) 959-964
7. Brinkman B.M.N., Zuijdgeest D., Kaijzel E.L., Breedveld F.C., and Verweij C.L. Relevance of the tumour necrosis factor alpha (TNF alpha)-308 promoter polymorphism in the TNF alpha gene regulation. J. Inflamm. 46 (1996) 32-41
8. Carpenter D., Abushama H., Bereczky S., Färnert A., Rooth I., Troye-Blomberg M., Quinnell R.J., and Shaw M.-A. Immunogenetic control of antibody responsiveness in a malaria endemic area. Hum. Immunol. 68 (2007) 165-169
9. Cornélis F., Hashimoto L., Loveridge J., MacCarthy A., Buckle V., Julier C., and Bell J. Identification of a CA repeat at the TCRA locus using yeast artificial chromosomes: a general method for generating highly polymorphic markers at chosen loci. Genomics 13 (1992) 820-825
10. Craddock T.P., Zumla A.M., Ollier W.E.R., Chintu C.Z., Muyinda G.P., Lancaster F.C., and Boylston A.W. Predominance of one T-cell antigen receptor BV haplotype in African populations. Immunogenetics 51 (2000) 231-237
11. Donaldson I., Shefta J., Hill A.V.S., and Boylston A. Malaria is not responsible for the selection of the TCRβ-subunit variable gene haplotypes in The Gambia. Immunogenetics 53 (2002) 894-899
12. Donaldson I., Shefta J., Lawson C.A., Bushnell J.A., Morgan A.W., Isaacs J.D., Carpenter D., Shaw M.-A., Rooth I., Quinnell R.J., Zumla A.M., Ollier W.E.R., Chintu C.Z., Muyinda G.P., Hill A.V.S., and Boylston A.W. Unique TCR-β subunit variable gene haplotypes in Africa. Immunogenetics 53 (2002) 884-893
13. Erlich H.A. HLA class II gene polymorphisms: DNA typing evolution and relationship to disease susceptibility. In: Erlich H.A. (Ed). PCR Technology: Principles and Applications for DNA Amplifications (1989), Stockton Press, New York 193-208
14. Farnert A., Snounou G., Rooth I., and Bjorkman A. Daily dynamics of Plasmodium falciparum sub populations in asymptomatic children in a holoendemic area. Am. J. Trop. Med. Hyg. 56 (1997) 538-547
15. Ferrante A., Staugas R.E.M., Rowan-Kelly B., Bresatz S., Kumaratilake L.M., Rzepczyk C.M., and Adolf G.R. Production of tumour necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria and malaria parasites. Infect. Immun. 58 (1990) 3994-4004
16. Flori L., Delahaye N.F., Iraqi F.A., Hernandez-Valladares M., Fumoux F., and Rihet P. TNF as a malaria candidate gene: polymorphism-screening and family based association analysis of mild malaria attack and parasitaemia in Burkina Faso. Genes Immun. 6 (2005) 472-480
17. Flori L., Kumulugui B., Aucan C., Esnault C., Traore A.S., Fumoux F., and Rihet P. Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-33. Genes Immun. 4 (2003) 265-268
18. Flori L., Sawadogo S., Esnault C., Delahaye F., Fumoux F., and Rihet P. Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso. Hum. Mol. Genet. 12 (2003) 375-378
19. Garcia A., Cot M., Chippaux J.P., Ranque S., Feingold J., Demenais F., and Abel L. Genetic control of blood infection levels in human malaria: evidence for a complex genetic model. Am. J. Trop. Med. Hyg. 58 (1998) 480-488
20. Garcia A., Marquet S., Bucheton B., Hillaire D., Cot M., Fievet N., Dessain A.J., and Abel L. Linkage analysis of the blood Plasmodium falciparum levels: linkage of the 5q31-q33 chromosome region. Am. J. Trop. Med. Hyg. 58 (1998) 705-709
21. Gourley I.S., Kurtis J.D., Kamoun M., Amon J.J., and Duffy P.E. Profound bias in inteferon-γ and interleukin-6 allele frequencies in Western Kenya, where severe malaria is common in children. J. Infect. Dis. 186 (2002) 1007-1012
22. Huizinga T.W.J., Westendorp R.G.J., Bollen E.L.E.M., Keijers V., Brinkman B.M.N., Langermans J.A.M., Breedveld F.C., Verweij C.L., van de Gaer L., Dams L., Crusius J.B., Garcia-Gonzalez A., van Oosten B.W., Polman C.H., and Pena A.S. TNF-α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J. Neuroimmunol. 72 (1997) 149-153
23. Jepson A.P., Sisay-Joof F., Banya W., Hassan-King M., Frodsham A., Bennett S., Hill A.V.S., and Whittle H. Genetic linkage of mild malaria to the major histocompatibilty complex in Gambian children: study of affected sibling pairs. Br. Med. J. 315 (1997) 96-97
24. Knight J.C., and Kwiatkowski D. Inherited variability of tumor necrosis factor production and susceptibility to infectious disease. Proc. Assoc. Am. Phys. 111 (1999) 290-298
25. Kwiatkowski D., Hill A.V.S., Sambou I., Twumasi P., Castracane J., Manogue K.R., Cerami A., Brewster D.R., and Greenwood B.M. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336 (1990) 1201-1204
26. Kwiatkowski D.P. How malaria has affected the human genome and what human genetics can teach us about malaria. Am. J. Hum. Genet. 77 (2005) 171-192
27. Louis E., Franchimont D., Piron A., Gevaert Y., Schaaf-Lafontaine N., Roland S., Mahieu P., Malaise M., de Groote D., Louis R., and Belaiche J. Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin. Exp. Immunol. 113 (1998) 401-406
28. Mackinnon M.J., Gunawarden D.M., Rajakaruna J., Weeasingha S., Mendis K.N., and Carter R. Quantifying genetic and non-genetic contributions to malaria infection in a Sri Lankan population. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 12661-12666
29. Mackinnon M.J., Mwangi T.W., Snow R.S., Marsh K., and Williams T.N. Heritability of malaria in Africa. PloS Med. 2 (2005) 1253-1259
30. May J., Meyer C.G., Kun J.F.J., Lell B., Luckner D., Dippmann A.K., Bienzle U., and Kremsner P.G. HLA class II factors associated with Plasmodium falciparum merozoite surface antigen allele families. J. Infect. Dis. 179 (1999) 1045-1942
31. McGuire W., Hill A.V.S., Allsopp C.E.M., Greenwood B.M., and Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 371 (1994) 508-511
32. Meyer C.G., May J., Luty A.J., Lell B., and Kremsner P.G. TNF-alpha-308A associated with shorter intervals of Plasmodium falciparum reinfections. Tissue Antigens 59 (2002) 287-292
33. Mycko M., Kowalski W., Kwinkowski M., Buenafe A.C., Szymanska B., Tronczynska E., Plucienniczak A., and Selmaj K. Multiple sclerosis: the frequency of allelic forms of tumour necrosis factor and lymphotaxin-alpha. J. Neuroimmunol. 84 (1998) 198-206
34. O'Connell J.R., and Weeks D.E. Pedcheck: a program for identifying genotyping incompatibilities in linkage analysis. Am. J. Hum. Genet. 63 (1998) 259-266
35. Rihet P., Traore Y., Abel L., Aucan C., Troare-Leroux T., and Fumoux F. Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. Am. J. Hum. Genet. 63 (1998) 498-505
36. Rooth, I., 1992. Malaria morbidity and control in a Tanzanian village, Doctoral thesis. Karolinska Institutet, Stockholm.
37. Spielman R.S., McGinnis R.E., and Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52 (1993) 506-516
38. Subrahmanyan L., Eberle M.A., Clark A.G., Kruglak L., and Nickerson D.A. Sequence variation and linkage disequilibrium in the human T cell receptor β (TCRB) locus. Am. J. Hum. Genet. 69 (2001) 381-395
39. Timmann C., Evans J.A., König I.R., Kleensang A., Rüschendorf F., Lenzen J., Sievertsen J., Becker C., Enuameh Y., Kwakye K.O., Opoku E., Browne E.N.L., Zieger A., Nürnberg P., and Horstmann R.D. Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet. 3 (2007) 393-400
40. Ubalee R., Suzuki F., Kikuchi M., Tasanor O., Wattanagoon Y., Ruangweerayut R., Na-Bangchang K., Karbwang J., Kimura A., Itoh K., Kanda T., and Hirayama K. Strong association of a tumour necrosis factor-α promoter allele with cerebral malaria in Myanmar. Tissue Antigens 58 (2001) 407-410
41. Wattavidanage J., Carter R., Perera K.L.R.L., Munasingha A., Bandara S., Mcguiness D., Wickramasinghe A.R., Alles H.K., Mendis K.N., and Premawansa S. TNF alpha*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans. Clin. Exp. Immunol. 115 (1999) 350-355
42. Wei S., Charmley P., Birchfield R., and Concannon I.P. Human T-cell receptor Vβ gene polymorphism and multiple sclerosis. Am. J. Hum. Genet. 56 (1995) 963-969
43. Wilson A.G., Symons J.A., McDowell T.L., McDevitt H.O., and Duff G.W. Effects of a polymorphism in the human tumour necrosis factor α promoter on transcriptional activation. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 3195-3199
44. Xie X., and Ott J. Testing linkage disequilibrium between a disease gene and marker loci. Am. J. Hum. Genet 53, Suppl. (1993) 1107 (abstract)