Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-q33

Genes and Immunity

Volumn 4, Issue 4, 2003, Pages 265-268

  Flori, L ^a   Kumulungui, B ^b   Aucan, C ^a   Esnault, C ^a   Traore A S ^b   Fumoux, F ^a   Rihet, P ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITÉ DE OUAGADOUGOU   (Burkina Faso)

Author keywords

Genetic linkage; Malaria; Parasitemia; Plasmodium falciparum; Quantitative transmission disequilibrium test; Variance components

Indexed keywords

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; CHROMOSOME 5Q; CHROMOSOME MAP; COMPUTER PROGRAM; CONTROLLED STUDY; ENDEMIC DISEASE; GENE CONTROL; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HERITABILITY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MICROSATELLITE MARKER; MULTIVARIATE ANALYSIS; NONPARAMETRIC TEST; PEDIGREE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; ANIMAL; CHROMOSOME 5; ERYTHROCYTE; FEMALE; GENETIC LINKAGE; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; PARASITOLOGY; PRESCHOOL CHILD; QUANTITATIVE TRAIT LOCUS;

PLASMODIUM FALCIPARUM;

MICROSATELLITE DNA;

ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 5; ERYTHROCYTES; FEMALE; HUMANS; LINKAGE (GENETICS); MALARIA, FALCIPARUM; MALE; MICROSATELLITE REPEATS; PLASMODIUM FALCIPARUM; QUANTITATIVE TRAIT LOCI;

EID: 0346154592     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363960     Document Type: Article

References (25)

1. Haldane JBS. The rate of mutation of human genes. Proc. VIII Int Cong. Genet. Hereditas 1949; 35: 267-273.
2. Hill AV. The immunogenetics of human infectious diseases. Annu Rev Immunol 1998; 16: 593-617.
3. Kwiatkowski D. Genetic susceptibility to malaria getting complex. Curr Opin Genet Dev 2000; 10: 320.
4. Abel L, Cot M, Mulder L, Carnevale P, Feingold J. Segregation analysis detects a major gene controlling blood infection levels in human malaria. Am J Hum Genet 1992; 50: 1308-1317.
5. Garcia A, Cot M, Chippaux JP et al. Genetic control of blood infection levels in human malaria: evidence for a complex genetic model. Am J Trop Med Hyg 1998; 58: 480-488.
6. Rihet P, Abel L, Traore Y, Traore-Leroux T, Aucan C, Fumoux F. Human malaria: segregation analysis of blood infection levels in a suburban area and a rural area in Burkina Faso. Genet Epidemiol 1998; 15: 435-450.
7. Jepson A, Sisay JF, Banya W et al. Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs. BMJ 1997; 315: 96-97.
8. Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 1998; 351: 265-266.
9. Aucan C, Traore Y, Fumoux F, Rihet P. Familial correlation of immunoglobulin G subclass responses to Plasmodium falciparum antigens in Burkina Faso. Infect Immun 2001; 69: 996-1001.
10. Migot-Nabias F, Mombo LE, Luty AJ et al. Human genetic factors related to susceptibility to mild malaria in Gabon. Gene Immun 2000; 1: 435-441.
11. Sjoberg K, Lepers JP, Raharimalala L et al. Genetic regulation of human anti-malarial antibodies in twins. Proc Natl Acad Sci U S A 1992; 89: 2101-2104.
12. Stirnadel HA, Beck HP, Alpers MP, Smith TA. Genetic analysis of IgG subclass responses against RESA and MSP2 of Plasmodium falciparum in adults in Papua New Guinea. Epidemiol Infect 2000; 124: 153-162.
13. Rihet P, Traore Y, Abel L, Aucan C, Traore-Leroux T, Fumoux F. Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. Am J Hum Genet 1998; 63: 498-450.
14. Traore Y, Rihet P, Traore-Leroux T et al. Analysis of the genetic factors controlling malarial infection in man. Sante 1999; 9: 53-59.
15. Kruglyak L, Daly MJ, Reeve DM, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58: 1347-1363.
16. Garcia A, Marquet S, Bucheton B et al. Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31-q33 chromosome region. Am J Trop Med Hyg 1998; 58: 705-709.
17. Marquet S, Abel L, Hillaire D et al. Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33. Nat Genet 1996; 14: 181-184.
18. Muller-Myhsok B, Stelma FF, Guisse-Sow F et al. Further evidence suggesting the presence of a locus, on human chromosome 5q31-q33, influencing the intensity of infection with Schistosoma mansoni. Am J Hum Genet 1997; 61: 452-454.
19. Meyers DA, Postma DS, Panhuysen CI et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994; 23: 464-470.
20. Xu J, Postma DS, Howard TD et al. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet 2000; 67: 1163-1173.
21. Vigual A, Gyapay G, Hazan J et al. A non-radioactive multiplex procedure for genotyping of microsatellite markers. In: Adolph, K. (ed). Methods in Molecular Genetics 1: Gene and Chromosome Analysis Academic Press: San Diego, 1993, pp 211-221.
22. Dib C, Faure S, Fizames C et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 1996; 380: 152-154.
23. Pratt SC, Daly MJ, Kruglyak L. Exact multipoint quantitativetrait linkage analysis in pedigrees by variance components. Am J Hum Genet 2000; 66: 1153-1157.
24. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-3446.
25. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.