Glucose and TGFβ2 modulate the viability of cultured human retinal pericytes and their VEGF release

Current Eye Research

Volumn 33, Issue 11-12, 2008, Pages 984-993

  Vidro, Eileen K ^a   Gee, Stephen ^b   Unda, Richard ^a   Ma, Jian Xing ^b   Tsin, Andrew ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Diabetic retinopathy; Human retinal pericytes; Hyperglycemia; TGF 2; VEGF

Indexed keywords

GLUCOSE; TRANSFORMING GROWTH FACTOR BETA2; VASCULOTROPIN; VASCULOTROPIN A;

ARTICLE; CELL COUNT; CELL CULTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PERICYTE; PRIORITY JOURNAL; RETINA; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOSE; HUMANS; PERICYTES; RETINA; TRANSFORMING GROWTH FACTOR BETA2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 57649129441     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680802450976     Document Type: Article

References (63)

1. Pickup JC, Williams G. Textbook of Diabetes. 2nd ed. Oxford/ Cambridge, MA: Blackwell Science, 1997:48.
2. Li WY, Zhou Q, Tang L, Qin M, Hu TS. Intramural pericyte degeneration in early diabetic retinopathy study in vitro. Chin Med J (Engl) 1990;103:7-13.
3. Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480-1487.
4. Pe'er J, Folberg R, Itin A, Gnessin H, Hemo I, Keshet E. Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy. Br J Ophthalmol 1996;80:241-245.
5. Hirase K, Ikeda T, Sotozono C, Nishida K, Sawa H, Kinoshita S. Transforming growth factor beta2 in the vitreous in proliferative diabetic retinopathy. Arch Ophthalmol 1998;116:738-741.
6. Ochiai Y, Ochiai H. Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes. Jpn J Ophthalmol 2002;46:249-253.
7. Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000;55:15-35; discussion 15-36.
8. Aiello LP, Northrup JM, Keyt BA, Takagi H, Iwamoto MA. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch Ophthalmol 1995;113:1538-1544.
9. Adamis AP, Shima DT, Yeo KT, et al. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun 1993;193:631-638.
10. Simorre-Pinatel V, Guerrin M, Chollet P, et al. Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway. Invest Ophthalmol Vis Sci 1994;35:3393-3400.
11. Yamashita H, Tobari I, Sawa M, et al. [Functions of the transforming growth factor-beta superfamily in eyes]. Nippon Ganka Gakkai Zasshi 1997;101:927-947.
12. Pfeffer BA, Flanders KC, Guerin CJ, Danielpour D, Anderson DH. Transforming growth factor beta 2 is the predominant isoform in the neural retina, retinal pigment epithelium-choroid, and vitreous of the monkey eye. Exp Eye Res 1994;59:323-333.
13. Barnard JA, Lyons RM, Moses HL. The cell biology of transforming growth factor beta. Biochim Biophys Acta 1990;1032:79-87.
14. Gary Lee YC, Melkerneker D, Thompson PJ, Light RW, Lane KB. Transforming growth factor beta induces vascular endothelial growth factor elaboration from pleural mesothelial cells in vivo and in vitro. Am J Respir Crit Care Med 2002;165:88-94.
15. Malecaze F, Clamens S, Simorre-Pinatel V, et al. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol 1994;112:1476-1482.
16. Nagineni CN, Samuel W, Nagineni S, et al. Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: Involvement of mitogen-activated protein kinases. J Cell Physiol 2003;197:453-462.
17. Renner U, Lohrer P, Schaaf L, et al. Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cells. Endocrinology 2002;143:3759-3765.
18. Saadeh PB, Mehrara BJ, Steinbrech DS, et al. Transforming growth factor-beta1 modulates the expression of vascular endothelial growth factor by osteoblasts. Am J Physiol 1999;277:C628-637.
19. Bian ZM, Elner SG, Elner VM. Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells. Exp Eye Res 2007;84:812-822.
20. Gitlin JD, D'Amore PA. Culture of retinal capillary cells using selective growth media. Microvasc Res 1983;26:74-80.
21. Herman IM, D'Amore PA. Microvascular pericytes contain muscle and non-muscle actins. J Cell Biol 1985;101:43-52.
22. Beltramo E, Berrone E, Giunti S, Gruden G, Perin PC, Porta M. Effects of mechanical stress and high glucose on pericyte proliferation, apoptosis, and contractile phenotype. Exp Eye Res 2006;83:989-994.
23. Pomero F, Allione A, Beltramo E, et al. Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes. Diabetologia 2003;46:416-419.
24. Du Y, Sarthy VP, Kern TS. Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. Am J Physiol Regul Integr Comp Physiol 2004;287:R735-741.
25. Browning AC, Alibhai A, McIntosh RS, Rotchford AP, Bhan A, Amoaku WM. Effect of diabetes mellitus and hyperglycemia on the proliferation of human Tenon's capsule fibroblasts: Implications for wound healing after glaucoma drainage surgery. Wound Repair Regen 2005;13:295-302.
26. Rojas S, Rojas R, Lamperti L, Casanello P, Sobrevia L. Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases, and nitric oxide in human umbilical vein endothelium. Exp Physiol 2003;88:209-219.
27. Duffy A, Liew A, O'Sullivan J, Avalos G, Samali A, O'Brien T. Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins. Endothelium 2006;13:9-16.
28. Heimsath EG, Jr, Unda R, Vidro E, Muniz A, Villazana-Espinoza ET, Tsin A. ARPE-19 cell growth and cell functions in euglycemic culture media. Curr Eye Res 2006;31:1073-1080.
29. Yao Y, Guan M, Zhao XQ, Huang YF. [Downregulation of the pigment epithelium derived factor by hypoxia and elevated glucose concentration in cultured human retinal pigment epithelial cells]. Zhonghua Yi Xue Za Zhi 2003;83:1989-1992.
30. Kim NH, Jung HH, Cha DR, Choi DS. Expression of vascular endothelial growth factor in response to high glucose in rat mesangial cells. J Endocrinol 2000;165:617-624.
31. Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, et al. Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 2002;62:901-913.
32. Natarajan R, Bai W, Lanting L, Gonzales N, Nadler J. Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am J Physiol 1997;273:H2224-2231.
33. Kim YS, Jung DH, Kim NH, Lee YM, Kim JS. Effect of magnolol on TGF-beta1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions. Eur J Pharmacol 2007;562:12-19.
34. Panchapakesan U, Sumual S, Pollock CA, Chen X. PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. Am J Physiol Renal Physiol 2005;289:F1153-1158.
35. Wang S, Wu X, Lincoln TM, Murphy-Ullrich JE. Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Diabetes 2003;52:2144-2150.
36. MacKay K, Striker LJ, Stauffer JW, Doi T, Agodoa LY, Striker GE. Transforming growth factor-beta. Murine glomerular receptors and responses of isolated glomerular cells. J Clin Invest 1989;83:1160-1167.
37. Henckaerts E, Langer JC, Orenstein J, Snoeck HW. The positive regulatory effect of TGF-beta2 on primitive murine hemopoietic stem and progenitor cells is dependent on age, genetic background, and serum factors. J Immunol 2004;173:2486-2493.
38. Majack RA. Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. J Cell Biol 1987;105:465-471.
39. Pepper MS, Vassalli JD, Orci L, Montesano R. Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res 1993;204:356-363.
40. Ibbotson KJ, Orcutt CM, Anglin AM, D'Souza SM. Effects of transforming growth factors beta 1 and beta 2 on a mouse clonal, osteoblast-like cell line MC3T3-E1. J Bone Miner Res 1989;4:37-45.
41. Berghuis HM, Dieudonne SC, Goei W, Veldhuijzen JP. Effects of TGF-beta 2 on mineral resorption in cultured embryonic mouse long bones; 45Ca release and osteoclast differentiation and migration. Eur J Orthod 1994;16:130-137.
42. Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF, Sporn MB. Type beta transforming growth factor: A bifunctional regulator of cellular growth. Proc Natl Acad Sci USA 1985;82:119-123.
43. Goodman LV, Majack RA. Vascular smooth muscle cells express distinct transforming growth factor-beta receptor phenotypes as a function of cell density in culture. J Biol Chem 1989;264:5241-5244.
44. Wang XJ, Dong Z, Zhong XH, et al. Transforming growth factor-beta1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells. Biochem Biophys Res Commun 2008;365:548-554.
45. Qian D, Lin HY, Wang HM, et al. Involvement of ERK1/2 pathway in TGF-beta1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev 2004;68:198-204.
46. Yamamoto T, Kozawa O, Tanabe K, et al. Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells. J Cell Biochem 2001;82:591-598.
47. Kaji T, Sakurai S, Yamamoto C, et al. Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture. Biol Pharm Bull 2004;27:1763-1768.
48. Border WA, Okuda S, Languino LR, Ruoslahti E. Transforming growth factor-beta regulates production of proteoglycans by mesangial cells. Kidney Int 1990;37:689-695.
49. Tokuda H, Hatakeyama D, Akamatsu S, et al. Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts. Arch Biochem Biophys 2003;415:117-125.
50. Wang L, Kwak JH, Kim SI, He Y, Choi ME. Transforming growth factor-β1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase 3-p38α and p38Δ mitogen-activated protein kinase-dependent pathway in murine mesangial cells. J Biol Chem 2004;279:33213-33219.
51. Vogt RR, Unda R, Yeh LC, Vidro EK, Lee JC, Tsin AT. Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells. J Cell Biochem 2006;98:1196-1202.
52. Igarashi M, Wakasaki H, Takahara N, et al. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 1999;103:185-195.
53. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
54. Papetti M, Shujath J, Riley KN, Herman IM. FGF-2 antagonizes the TGF-β1-mediated induction of pericyte alpha-smooth muscle actin expression: A role for myf-5 and Smad-mediated signaling pathways. Invest Ophthalmol Vis Sci 2003;44:4994-5005.
55. McMullen ME, Bryant PW, Glembotski CC, Vincent PA, Pumiglia KM. Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. J Biol Chem 2005;280:20995-21003.
56. Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 1990;346:281-284.
57. Heimer R, Bashey RI, Kyle J, Jimenez SA. TGF-β modulates the synthesis of proteoglycans by myocardial fibroblasts in culture. J Mol Cell Cardiol 1995;27:2191-2198.
58. Chen CP, Chang SC, Vivian Yang WC. High glucose alters proteoglycan expression and the glycosaminoglycan composition in placentas of women with gestational diabetes mellitus and in cultured trophoblasts. Placenta 2007;28:97-106.
59. Wahab NA, Harper K, Mason RM. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia. Biochem J 1996;316 (Pt 3):985-992.
60. Wahab NA, Parker S, Sraer JD, Mason RM. The decorin high glucose response element and mechanism of its activation in human mesangial cells. J Am Soc Nephrol 2000;11:1607-1619.
61. Fisher EJ, McLennan SV, Yue DK, Turtle JR. Cell-associated proteoglycans of retinal pericytes and endothelial cells: Modulation by glucose and ascorbic acid. Microvasc Res 1994;48:179-189.
62. Deissler H, Lang GK, Lang GE. TGFβ induces transdifferentiation of iBREC to αSMA-expressing cells. Int J Mol Med 2006;18:577-582.
63. Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation dependent and is associated with endothelial survival. Dev Biol 2003;264:275-288.