In vivo confocal microscopy for the evaluation of corneal microstructure in keratoconus

Current Eye Research

Volumn 33, Issue 11-12, 2008, Pages 933-939

  Mocan, Mehmet C ^a   Yilmaz, Pinar Topcu ^a   Irkec, Murat ^a   Orhan, Mehmet ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

In vivo confocal microscopy; Keratoconus; Keratocyte

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CELL DENSITY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA; CORNEA CELL; ENDOTHELIUM CELL; EPITHELIUM BASAL CELL; FEMALE; HUMAN; KERATOCONUS; KERATOMETRY; MAJOR CLINICAL STUDY; MALE; NERVE; PRIORITY JOURNAL; SLIT LAMP;

ADOLESCENT; ADULT; CELL COUNT; CORNEA; CORNEAL OPACITY; CORNEAL STROMA; CORNEAL TOPOGRAPHY; ENDOTHELIUM, CORNEAL; EPITHELIUM, CORNEAL; FEMALE; HUMANS; KERATOCONUS; MALE; MICROSCOPY, CONFOCAL; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 57649126122     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680802439219     Document Type: Article

References (29)

1. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297-319.
2. Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res. 1999;69:475-481.
3. Teng CC. Electron microscopy study of the pathology of keratoconus. Am J Ophthalmol. 1963;55:18-47.
4. Scroggs MW, Proia AD. Histopathological variation in keratoconus. Cornea. 1992;11:553-559.
5. Sawaguchi S, Yue BYJT, Sugar J, Gilboy JE. Three-dimensional scanning electron microscopic study of keratoconus corneas. Arch Ophthalmol. 1998;116:62-68.
6. Kaas-Hansen M. The histopathological changes of keratoconus. Acta Ophthalmologica. 1993;71:411-414.
7. Erie JC, Patel SV, McLaren JW, Nau CB, Hodge DO, Bourne WM. Keratocyte density in keratoconus. A confocal microscopy study (a). Am J Ophthalmol. 2002;134:689-695.
8. Hollingsworth JG, Efron N, Tullo AB. In vivo corneal confocal microscopy in keratoconus. Ophthal Physiol Opt. 2005;25:254-260.
9. Ucakhan OO, Kanpolat A, Yilmaz N, Ozkan M. In vivo confocal microscopy findings in keratoconus. Eye Contact Lens. 2006;32:183-191.
10. Mannion LS, Tromans C, O'Donnell C. An evaluation of corneal nerve morphology and function in moderate keratoconus. Contact Lens Ant Eye. 2005;28:185-192.
11. Hollingsworth JG, Bonshek RE, Efron N. Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy. Cornea. 2005;24:397-405.
12. Weed KH, Macewen CJ, Cox A, McGhee CN. Quantitative analysis of corneal microstructure in keratoconus utilizing in vivo confocal microscopy. Eye. 2007;21:614-623.
13. Efron N, Hollingsworth JG. New perspectives on keratoconus as revealed by corneal confocal microscopy. Clin Exp Optom.2008;91:34-55.
14. Mocan MC, Durukan I, Irkec M, Orhan M. Morphologic alterations of both the stromal and sub-basal nerves in the corneas of patients with diabetes. Cornea. 2006;25:769-773.
15. Wilson SE, He YG, Weng J, Li Q, McDowall AW, Vital M, Chwang EL. Epithelial injury induces keratocyte apoptosis: Hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res. 1996;62:325-327.
16. Nieuwendaal CP, Odenthal MT, Kok JH, Venema HW, Oosting J, Riemslag FC, Kijlstra A. Morphology and function of the corneal endothelium after long-term contact lens wear. Invest Ophthalmol Vis Sci. 1994;35:3071-3077.
17. Efron N. Contact lens-induced changes in the anterior eye as observed in vivo with the confocal microscope. Prog Ret Eye Res. 2007;26:398-436.
18. Niederer RL, Perumal D, Sherwin T, McGhee CN. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci. 2008;49:2964-2970.
19. Kaldawy RM, Wagner J, Ching S, Seigel GM. Evidence of apoptotic cell death in keratoconus. Cornea. 2002;21:206-209.
20. Sawaguchi S, Yue BYJT, Sugar J, Gilboy JE. Lysosomal enzyme abnormalities in keratoconus. Arch Ophthalmol. 1989;107:1507-1510.
21. Ku JY, Niederer RL, Patel DV, Sherwin T, McGhee CN. Laser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology. 2008;115:845-850.
22. Efron N, Perez-Gomez I, Morgan PB. Confocal microscopic observations of stromal keratocytes during extended contact lens wear. Clin Exp Optom. 2002;85:156-160.
23. Kallinikos P, Efron N. On the etiology of keratocyte loss during contact lens wear. Invest Ophthalmol Vis Sci. 2004;45:3011-3020.
24. Patel DV, Ku JY, Johnson R, McGhee CN. Laser scanning in vivo confocal microscopy and quantitative aesthesiometry reveal decreased corneal innervation and sensation in keratoconus. Eye. 2008;Mar 14 [Epub ahead of print].
25. Hollingsworth J, Perez-Gomez I, Abdul Mutalib H, Efron N. A population study of the normal cornea using an in vivo, slit-scanning confocal microscope. Optom. Vision Sci. 2001;78:706-711.
26. Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112:654-659.
27. Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res. 1999;69:475-481.
28. Brookes NH, Loh IP, Clover GM, Poole CA, Sherwin T. Involvement of corneal nerves in the progression of keratoconus. Exp Eye Res. 2003;77:515-524.
29. Patel DV, McGhee CNJ. Mapping the corneal sub-basal nerve plexus in keratoconus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2006;47:1348-1351.