From rapid in vitro screening to rapid in vivo screening in the drug discovery process

Neuropsychopharmacology

Volumn 34, Issue 1, 2009, Pages 251-252

  Carroll, F Ivy ^a   Houghten, Richard A ^b  

^a RTI INTERNATIONAL   (United States)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAPEPTIDE; PEPTIDE DERIVATIVE; TETRAPEPTIDE;

COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; DRUG APPROVAL; DRUG DETERMINATION; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL MODEL; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; SHORT SURVEY; TECHNIQUE;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; MODELS, BIOLOGICAL; PEPTIDE LIBRARY;

EID: 57649123179     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.160     Document Type: Short Survey

References (6)

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2. Houghten RA (1994). Soluble combinatorial libraries: extending the range and repetoire of chemical diversity. Methods Companion Methods Enzymol 6: 354-360.
3. Houghten RA, Dooley CT, Appel JR (2006). In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands. AAPS J 8: E371-E382.
4. Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A et al (2008). Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. J Comb Chem 10: 3-19.
5. Liu B, Chang J, Gordon WP, Isbell J, Zhou Y, Tuntland T (2008). Snapshot pk: a rapid rodent in vivo preclinical screening approach. Drug Discov Today 13: 360-361.
6. Shukaliak Quandt J, Borras E, Prat E, Gelderblom H, Houghten RA, Kashani A et al (2004). Peptidic complex mixtures as therapeutic agents in cns autoimmunity. Mol Immunol 40: 1075-1087.