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Volumn 46, Issue 12 SUPPL., 2008, Pages

A toxicologic and dermatologic assessment of cyclic acetates when used as fragrance ingredients

Author keywords

Acetates; Cyclic acetates; Fragrance; Review; Safety

Indexed keywords

1 ETHYNYLCYCLOHEXYL ACETATE; 1 METHYL 2 (1 METHYLPROPYL)CYCLOHEXYL ACETATE; 1 METHYL 4 (1 METHYLVINYL)CYCLOHEXYL ACETATE; 1,3,3 TRIMETHYL 2 NORBORNANYL ACETATE; 1,7,7 TRIMETHYLBICYCLO[4.4.0]DEC 3 YL ACETATE; 2 (1 METHYLPROPYL) 1 VINYLCYCLOHEXYL ACETATE; 2 TERT BUTYLCYCLOHEXYL ACETATE; 3 TERT BUTYLCYCLOHEXYL ACETATE; 4 (ISOPROPYL) 1 METHYLCYCLOHEXYL ACETATE; 4 METHYL 8 METHYLENETRICYCLO[3.3.1.1]DECAN 2 YL ACETATE; 4 TERT BUTYLCYCLOHEXYL ACETATE; ABIETYL ACETATE; ACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; ALPHA METHYLCYCLOHEXYLMETHYL ACETATE; AMYLCYCLOHEXYL ACETATE; CARBOXYLESTERASE; CYCLOCITRONELLENE ACETATE; CYCLOHEXYL ACETATE; CYCLOHEXYLCYCLOPENT 2 ENE 1 ACETATE; DECAHYDRO BETA NAPHTHYL 1 ACETATE; EPOXIDE; ESTER; FRAGRANCE; KETONE; MYRALDYL ACETATE; OCTAHYDRO 4,7 METHANO 1H INDENEMETHYL ACETATE; TRICYCLODECANYL ACETATE; TRICYCLODECENYL ACETATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; HYDROCARBON; PERFUME;

EID: 57649087950     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.09.039     Document Type: Review
Times cited : (33)

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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1977b. Acute toxicity studies with alpha-methylcyclohexylmethyl acetate. Unpublished Report from IFF Incorporated. Report Number 52621, 11 March. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1977f. Sensitization and irritation studies of myraldyl acetate in human subjects. Unpublished Report from Givaudan Corporation. Report Number 17234, 15 December. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1977h. Skin irritation and capacity for allergic sensitization determined by the open epicutaneous test (OET) on guinea pigs. Unpublished Report from Givaudan Corporation. Report Number 41613, 18 March. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1977i. Rabbit eye irritation test with 2-tert-butylcyclohexyl acetate. Unpublished Report from Quest International. Report Number 46634, 12 May. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1977m. Capacity for allergic sensitization determined by the intradermal test with Freund's Complete Adjuvant (FCAT) on guinea pigs. Unpublished Report from Givaudan Corporation. Report Number 41611, 18 March. RIFM, Woodcliff Lake, NJ, USA.
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    • 50) of amylcyclohexyl acetate (mixed isomers) in albino mice. Unpublished Report from IFF International. Report Number 50546, 24 May. RIFM, Woodcliff Lake, NJ, USA.
    • 50) of amylcyclohexyl acetate (mixed isomers) in albino mice. Unpublished Report from IFF International. Report Number 50546, 24 May. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979a. Acute dermal toxicity test in rabbits dose determination. Unpublished Report from IFF Incorporated. Report Number 47084, 6 March. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979b. Acute dermal toxicity of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in rabbits. Unpublished Report from Firmenich Incorporated. Report Number 17950, 5 September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979c. Acute oral toxicity test in rats treated with 4-tert-butylcyclohexyl acetate. Unpublished Report from IFF Incorporated. Report Number 47083, 30 April. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979d. Acute oral toxicity of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in rats. Unpublished Report from Firmenich Incorporated. Report Number 17949, 5 September. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979d. Acute oral toxicity of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in rats. Unpublished Report from Firmenich Incorporated. Report Number 17949, 5 September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979e. Repeated insult patch test/photosensitization study of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in human subjects. Unpublished Report from Firmenich Incorporated. Report Number 17952, 10 September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979f. Rabbit covered patch skin irritation test. Unpublished Report from Quest International. Report Number 46710, 20 November. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979g. Determination of phototoxicity in guinea pigs. Unpublished Report from Givaudan Corporation. Report Number 41609, 28 November. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979h. Rabbit covered patch test. Unpublished Report from Quest International. Report Number 46287, 8 December. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979i. Primary skin irritation study of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in rabbits. Unpublished Report from Firmenich Incorporated. Report Number 17951, 5 September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979j. Primary ocular irritation (rabbits). Unpublished Report from Firmenich Incorporated. Report Number 37332, 13 August. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979j. Primary ocular irritation (rabbits). Unpublished Report from Firmenich Incorporated. Report Number 37332, 13 August. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1979k. Primary eye irritation study of 1,7,7-trimethylbicyclo[4.4.0]dec-3-yl acetate in rabbits. Unpublished Report from Firmenich Incorporated. Report Number 17964, 5 September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980c. Ames metabolic activation test to assess the potential mutagenic effect of 4-tert-butylcyclohexyl acetate. Unpublished Report from Quest International. Report Number 46713, 5 February. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980c. Ames metabolic activation test to assess the potential mutagenic effect of 4-tert-butylcyclohexyl acetate. Unpublished Report from Quest International. Report Number 46713, 5 February. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980d. Ames metabolic activation test to assess the mutagenic potential effect of tricyclodecenyl acetate. Unpublished Report from Quest International. Report Number 46286, 20 February. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980d. Ames metabolic activation test to assess the mutagenic potential effect of tricyclodecenyl acetate. Unpublished Report from Quest International. Report Number 46286, 20 February. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980e. A guinea pig assay of photosensitizing potential. Unpublished Report from Givaudan Corporation. Report Number 41608, 4 February. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1980e. A guinea pig assay of photosensitizing potential. Unpublished Report from Givaudan Corporation. Report Number 41608, 4 February. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Acute oral toxicity to rats of d-cyclocitronellene acetate. Unpublished Report from BBA. Report Number 1773, 25 June. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Acute oral toxicity to rats of d-cyclocitronellene acetate. Unpublished Report from BBA. Report Number 1773, 25 June. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. Irritant effects of d-cyclocitronellene acetate on rabbit skin. Unpublished Report from BBA. Report Number 1770, 29 May. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. Irritant effects of d-cyclocitronellene acetate on rabbit skin. Unpublished Report from BBA. Report Number 1770, 29 May. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981d. Irritant effects of d-cyclocitronellene acetate on rabbit eye mucosa. Unpublished Report from BBA. Report Number 1772, 14 July and 27 August. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981d. Irritant effects of d-cyclocitronellene acetate on rabbit eye mucosa. Unpublished Report from BBA. Report Number 1772, 14 July and 27 August. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981e. Screening test for delayed contact hypersensitivity with d-cyclocitronellene acetate in the albino guinea pig. Unpublished Report from BBA. Report Number 1771, 30 April. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1981e. Screening test for delayed contact hypersensitivity with d-cyclocitronellene acetate in the albino guinea pig. Unpublished Report from BBA. Report Number 1771, 30 April. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982a. Acute toxicity studies. RIFM Report Number 1689, February-September. RIFM, Woodcliff Lake, NJ, USA.
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. Acute dermal toxicity of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in albino rabbits. Unpublished Report from Firmenich Incorporated. Report Number 38871, 21 July. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. Acute dermal toxicity of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in albino rabbits. Unpublished Report from Firmenich Incorporated. Report Number 38871, 21 July. RIFM, Woodcliff Lake, NJ, USA.
  • 111
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. Repeated insult patch test/photosensitization study of (3a.a.,4.a.,6.a.,7.a.,7a.a.)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylen e-4,7-methano-1H-inden-6-yl acetate in human subjects. Unpublished Report from Firmenich Incorporated. Report Number 38874, 21 May. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. Repeated insult patch test/photosensitization study of (3a.a.,4.a.,6.a.,7.a.,7a.a.)-3a,4,5,6,7,7a-hexahydro-3-methyl-5-methylen e-4,7-methano-1H-inden-6-yl acetate in human subjects. Unpublished Report from Firmenich Incorporated. Report Number 38874, 21 May. RIFM, Woodcliff Lake, NJ, USA.
  • 112
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. Single dose oral toxicity study of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in rats. Unpublished Report from Firmenich Incorporated. Report Number 38870, 21 July. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. Single dose oral toxicity study of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in rats. Unpublished Report from Firmenich Incorporated. Report Number 38870, 21 July. RIFM, Woodcliff Lake, NJ, USA.
  • 113
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982e. Report on human maximization studies. RIFM Report Number 1643, June 28. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982e. Report on human maximization studies. RIFM Report Number 1643, June 28. RIFM, Woodcliff Lake, NJ, USA.
  • 114
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    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982f. Primary skin irritation study of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in rabbits. Unpublished Report from Firmenich Incorporated. Report number 38872, 30 April. RIFM, Woodcliff Lake, NJ, USA.
    • RIFM (Research Institute for Fragrance Materials, Inc.), 1982f. Primary skin irritation study of (3a.alpha.,4.alpha.,6.alpha.,7.alpha.,7a.alpha.)-3a,4,5,6,7,7a-hexahydro -3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate in rabbits. Unpublished Report from Firmenich Incorporated. Report number 38872, 30 April. RIFM, Woodcliff Lake, NJ, USA.
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