Human CD8+ T-regulatory cells with low-avidity T-cell receptor specific for minor histocompatibility antigens

Human Immunology

Volumn 69, Issue 11, 2008, Pages 728-731

  Burlingham, William J ^a   Goulmy, Els ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD8 T regulatory cells; HLA tetramer; Minor H antigens; Tolerance; Transplantation

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TETRAMER;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; EFFECTOR CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; KIDNEY ALLOGRAFT; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROCHIMERISM; MOTHER; NONHUMAN; PARITY; PREGNANCY; PRIORITY JOURNAL; PROGENY; RECEPTOR AFFINITY; RECEPTOR BINDING; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; TUMOR VOLUME; VIRUS INFECTION;

CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DENDRITIC CELLS; FEMALE; H-Y ANTIGEN; HUMANS; ISOANTIGENS; KIDNEY TRANSPLANTATION; MATERNAL-FETAL EXCHANGE; NEOPLASMS; PREGNANCY; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION TOLERANCE; VIRUS DISEASES;

EID: 57649085061     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.08.289     Document Type: Article

References (28)

1. Scholer A., Hugues S., Boissonnas A., Fetler L., and Amigorena S. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 28 (2008) 258-270
2. Egen J.G., Kuhns M.S., and Allison J.P. CTLA-4: New insights into its biological function and use in tumor immunotherapy. Nat Immunol 3 (2002) 611-618
3. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., and Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Dec 5. Nature 420 (2002) 502-507
4. Sarangi P.P., Sehrawat S., Suvas S., and Rouse B.T. IL-10 and natural regulatory T cells: Two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology. J Immunol 180 (2008) 6297-6306
5. Wherry E.J., Barber D.L., Kaech S.M., Blattman J.N., and Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A 101 (2004) 16004-16009
6. Wherry E.J., Day C.L., Draenert R., et al. HIV-specific CD8 T cells express low levels of IL-7Ralpha: Implications for HIV-specific T cell memory. Virology 353 (2006) 366-373
7. Garba M.L., Pilcher C.D., Bingham A.L., Eron J., and Frelinger J.A. HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells. J Immunol 168 (2002) 2247-2254
8. Cai J., Lee J., Jankowska-Gan E., Derks R., Pool J., Mutis T., et al. Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance. J Exp Med 199 (2004) 1017-1023
9. Wieles B., Pool J., Derks R., Burlingham W.J., and Goulmy E. Detection of microchimerism by minor histocompatibility antigen HA-1 allele-specific nested polymerase chain reaction. Biol Blood Marrow Transplant 11 (2005) 345-348
10. Van Halteren AG, Jankowska-Gan E, Kloosterman-Joosten A, Blokland E, Pool J, Brand A, et al. Naturally acquired tolerance and sensitization to minor H antigens in healthy family members. [submitted for publication].
11. Oki S., Chiba A., Yamamura T., and Miyake S. The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113 (2004) 1631-1640
12. Chang C.C., Ciubotariu R., Manavalan J.S., et al. Tolerization of dendritic cells by T(S) cells: The crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 3 (2002) 237-243
13. Stein-Streilein J., and Streilein J.W. Anterior chamber associated immune deviation (ACAID): Regulation, biological relevance, and implications for therapy. Int Rev Immunol 21 (2002) 123-152
14. Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg D, Zhen Y, Torrealba J, Burlingham WJ. Acquired tolerance to non-inherited maternal antigens is correlated with widespread tissue distribution of maternal microchimerism [Manuscript in preparation].
15. Chan W.F., Razavy H., Luo B., Shapiro A.M., and Anderson C.C. Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras. J Immunol 180 (2008) 5177-5186
16. Sloan-Lancaster J., and Allen P.M. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu Rev Immunol 14 (1996) 1-27
17. Gillespie G., Mutis T., Schrama E., Kamp J., Esendam B., Falkenburg J.F., et al. HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand. Hematol J 1 (2000) 403-410
18. Derks R.A., Jankowska-Gan E., Xu Q., and Burlingham W.J. Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1. J Immunol 179 (2007) 3443-3451
19. Verdijk R.M., Mutis T., Wilke M., Pool J., Schrama E., Brand A., and Goulmy E. Exclusive TCRVbeta chain usage of ex vivo generated minor histocompatibility antigen HA-1 specific cytotoxic T cells: Implications for monitoring of immunotherapy of leukemia by TCRBV spectratyping. Hematol J 3 (2002) 271-275
20. Maile R., Pop S.M., Tisch R., Collins E.J., Cairns B.A., and Frelinger J.A. Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol 36 (2006) 397-410
21. Maile R., Wang B., Schooler W., Meyer A., Collins E.J., and Frelinger J.A. Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers. J Immunol 167 (2001) 3708-3714
22. Maile R., Siler C.A., Kerry S.E., Midkiff K.E., Collins E.J., and Frelinger J.A. Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol 174 (2005) 619-627
23. Kienzle N., Olver S., Buttigieg K., Groves P., Janas M.L., Baz A., and Kelso A. Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4. J Immunol 174 (2005) 2021-2029
24. Zhang Z.X., Yang L., Young K.J., DuTemple B., and Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 6 (2000) 782-789
25. Burlingham W.J., Grailer A.P., Heisey D.M., et al. The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors [See comments]. N Engl J Med 339 (1998) 1657-1664
26. van Rood J.J., Loberiza F.R.J., Zhang M.J., et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood 99 (2002) 1572-1577
27. Blohm U., Roth E., Brommer K., Dumrese T., Rosenthal F.M., and Pircher H. Lack of effector cell function and altered tetramer binding of tumor-infiltrating lymphocytes. J Immunol 169 (2002) 5522-5530
28. Fasso M., Waitz R., Hou Y., Rim T., Greenberg N.M., Shastri N., Fong L., and Allison J.P. SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. Proc Natl Acad Sci U S A 105 (2008) 3509-3514