Phospholipase A2 in meconium-induced lung injury

Journal of Perinatology

Volumn 28, Issue , 2008, Pages S120-S122

  Kaapa P ^a   Soukka, H ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE A2; DEXAMETHASONE; LUNG SURFACTANT; MEPACRINE;

BLOOD; HUMAN; LUNG INJURY; MECONIUM; MECONIUM ASPIRATION; NEWBORN; PHYSIOLOGY; REVIEW; ACUTE LUNG INJURY; CONFERENCE PAPER; INFLAMMATION; LUNG EDEMA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREAS; RESPIRATORY DISTRESS; UPREGULATION;

HUMANS; INFANT, NEWBORN; LUNG INJURY; MECONIUM; MECONIUM ASPIRATION SYNDROME; PHOSPHOLIPASES A2;

EID: 57549117414     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2008.147     Document Type: Article

References (25)

1. Wiswell TE. Meconium staining and the meconium aspiration syndrome. In: Stevenson D, Benitz WE, Sunshine P (eds). Fetal and Neonatal Brain Injury. Mechanisms, Management and the Risks of Practice. Cambridge University Press: Cambridge, UK, 2003, pp 612–635.
2. Davey AM, Becker JD, Davis JM. Meconium asiration syndrome: physiological and inflammatory changes in a newborn piglet model. Pediatr Pulmonol 1993; 16: 101–108.
3. de Beaufort AJ, Pelikan DMV, Elferink JGR, Berger HM. Effect of interleukin 8 in meconium on in-vitro neutrophil chemotaxis. Lancet 1998; 352: 102–105.
4. Holopainen R, Aho H, Laine J, Peuravuori H, Soukka H, Kaapa P. Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs. Pediatr Res 1999; 46: 626–632.
5. Dennis EA. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 1994; 269: 13057–13060.
6. Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. On the diversity of secreted phospholipases A2. J Biol Chem 1999; 274: 31195–31202.
7. Triggiani M, Granata F, Frattini A, Marone G. Activation of human inflammatory cells by secreted phospholipases A2. Biochim Biophys Acta 2006; 1761(11): 1289–1300.
8. Niewoehner DE, Rice K, Duane P, Sinha AA, Gebhard R, Wangensteen D. Induction of alveolar epithelial injury by phospholipase A2. J Appl Physiol 1989; 66: 261–267.
9. Vadas P, Pruzanski W. Role of secretory phospholipases A2 in the pathobiology of disease. Lab Invest 1986; 55: 391–404.
10. Kim DK, Fukuda T, Thompson BT, Cockrill B, Hales C, Bonventre JV. Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. Am J Physiol 1995; 269: L109–L118.
11. Arbibe L, Koumanov K, Vial D, Rougeot C, Faure G, Havet N et al. Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. J Clin Invest 1998; 102: 1152–1160.
12. Seilhamer JJ, Randall TL, Yamanaka M, Johnson LK. Pancreatic phospholipase A2: isolation of the human gene and cDNA from porcine pancreas and human lung. DNA 1986; 5: 519–527.
13. Hite RD, Seeds MC, Jacinto RB, Balasubramanian R, Waite M, Bass D. Hydrolysis of surfactant-associated phosphatidylcholine by mammalian secretory phospholipase A2. Am J Physiol Lung Cell Mol Physiol 1998; 275: L740–L747.
14. Granata F, Petraroli A, Boilard E, Bezzine S, Bollinger J, Del Vecchio L et al. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 2005; 174: 464–474.
15. Sommers CD, Bobbitt JL, Bemis KG, Snyder DW. Porcine pancreatic phospholipase A2-induced contractions of guinea pig lung pleural strips. Eur J Pharmacol 1992; 216: 87–96.
16. Korhonen K, Soukka H, Halkola L, Peuravuori H, Aho H, Pulkki K et al. Meconium induces only localized inflammatory lung injury in piglets. Pediatr Res 2003; 54(2): 192–197.
17. Sippola T, Aho H, Peuravuori H, Lukkarinen H, Gunn J, Kaapa P. Pancreatic phospholipase A2 contributes to lung injury in experimental meconium aspiration. Pediatr Res 2006; 59(5): 641–645.
18. Schrama AJJ, de Beaufort AJ, Sukul YRM, Jansen SM, Poorthuis BJHM, Berger HM. Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study. Acta Paediatr 2001; 90: 412–416.
19. Holm BA, Keicher L, Liu M, Sokolowski J, Enhorning G. Inhibition of pulmonary surfactant function by phospholipases. J Appl Physiol 1991; 71: 317–321.
20. Kishino J, Ohara O, Nomura K, Kramer RM, Arita H. Pancreatic-type phospholipase A2 induces Group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells. J Biol Chem 1994; 269: 5092–5098.
21. Hoeck WG, Ramesha CS, Chang DJ, Fan N, Heller RA. Cytoplasmic phopholipase A2 activity and gene expression are simulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. Proc Natl Acad Sci USA 1993; 90: 4475–4479.
22. Holopainen R, Laine J, Halkola L, Aho H, Kaapa P. Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration. Pediatr Res 2001; 49: 1–7.
23. Lindenskov PH, Castellheim A, Aamodt G, Saugstad OD, Mollnes TE. Complement activation reflects severity of meconium aspiration syndrome in newborn pigs. Pediatr Res 2004; 56: 810–817.
24. Anderson BO, Moore EE, Banerjee A. Phospholipase A2 regulates critical inflammatory mediators of multiple organ failure. J Surg Res 1994; 56: 199–205.
25. Aaltonen M, Soukka H, Halkola L, Jalonen J, Holopainen IE, Kaapa PO. Meconium aspiration induces oxidative injury in the hippocampus of newborn piglets. Early Hum Dev 2005; 81(5): 439–447.