Down-regulatory effect of usnic acid on nuclear factor-κB-dependent tumor necrosis factor-α and inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7

Phytotherapy Research

Volumn 22, Issue 12, 2008, Pages 1605-1609

  Jin, Ju Qing ^a   Li, Cui Qin ^a   He, Lang Chong ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Inducible nitric oxide synthase; Nitric oxide; Nuclear factor B; Tumor necrosis factor; Usnic acid

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; USNIC ACID;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); DOWN REGULATION; GENE EXPRESSION; IC 50; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOFURANS; CELL LINE; CELL SURVIVAL; DOWN-REGULATION; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TUMOR NECROSIS FACTOR-ALPHA; USNEA;

EID: 57549085059     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2531     Document Type: Article

References (24)

1. Aktan F. 2004. iNOS-mediated nitric oxide production and its regulation. Life Sci 75: 639-653.
2. Archer S. 1993. Measurement of nitric oxide in biological models. FASEB J 7: 349.
3. Beutler B. 1995. TNF, immunity and inflammatory disease: lessons of the past decade. J Invest Med 43: 227-235.
4. Bredt DS, Snyder SH. 1990. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87: 682-685.
5. Edwards HG, Newton EM, Wynn-Williams DD. 2003. Molecular structural studies of lichen substances Π: atranorin, gyrophoric acid, fumarprotocertraric acid, rhizocarpic acid, calycin, pulvinic dilactone and usnic acid. J Mol Struct 651-653: 27-37.
6. Guha M, Mackman N. 2001. LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94.
7. Hauser B, Bracht H, Matejovic M, Radermacher P, Venkatash B. 2005. Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg 101: 488-498.
8. Ingolfsdottir K. 2002. Usnic acid. Phytochemistry 61: 729-736.
9. Ingolfsdottir K, Chung GA, Skulason VG. 1998. Antimycobacterial activity of lichen metabolites in vitro. Eur J Pharm Sci 6: 141-144.
10. Israel A. 2000. The IKK complex: an integrator of all signals that activate NF-kB? Trends Cell Biol 10: 129-133.
11. Kilbourn RG, Belloni P. 1990. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer I 82: 772-776.
12. Kim BH, Cho SM, Reddy AM, Kim YS, Min KR, Kim Y. 2005. Down-regulatory effect of quercitrin gallate on nuclear factor-kB-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7 Biochem Pharmacol 69: 1577-1583.
13. Klosterhalfen B, Bhardwaj RS. 1998. Septic shock. Gen Pharmacol 31: 25-32.
14. MacMicking J, Xie QW, Nathan C. 1997. Nitric oxide and macrophage function. Annu Rev Immunol 15: 323-350.
15. Magnani M, Crinelli R, Bianchi M, Antonelli A. 2000. The ubiquitin dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB). Curr Drug Targets 1: 387-399.
16. Mayer M, O'Neill MA, Murray KE. 2005. Usnic acid: a non-genotoxic compound with anti-cancer properties. Anticancer Drugs 16: 805-809.
17. Ohshima H, Tatemichi M, Sawa T. 2003. Chemical basis of inflammation-induced carcinogenesis. Arch Biochem Biophys 417: 3-11.
18. Okuyama E, Umeyama K, Yomazaki M. 1995. Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta. Planta Med 61: 113-115.
19. Titheradge MA. 1999. Nitric oxide in septic shock. Biochim Biophys Acta 1411: 437-455.
20. Tripathi P, Aggarwal A. 2006. NF-kB transcription factor: a key player in the generation of immune response. Curr Sci 90: 519-531.
21. Tubar A, Florio C, Luxich E, Vertua R, Loggia RD, Yasuimoto T. 1996. Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels [J]. Toxicon 34: 965-974.
22. Vassalli P. 1992. The pathophysiology of tumor necrosis factor. Annu Rev Immunol 10: 411-452.
23. Vijayakumar CS, Viswanathan S, Kannappa-Reddy M et al. 2000. Anti-inflammatory activity of (+)-usnic acid. Fitoterapia 71: 546-566.
24. Wu RQ, Xu YX, Song XH, Chen LJ, Meng XJ. 2002. Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture. World J Gastroenterol 8: 131-134.