Inhibition of phosphate-induced apoptosis in resting zone chondrocytes by thrombin peptide 508

Cells Tissues Organs

Volumn 189, Issue 1-4, 2008, Pages 56-59

  Zhong, Ming ^a   Carney, Darrell H ^b   Ryaby, James T ^c   Schwartz, Zvi ^a   Boyan, Barbara D ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c OrthoLogic Corporation   (United States)

Author keywords

Apoptosis; Cartilage research; Chondrocytes; Growth plate; Phosphate; Thrombin

Indexed keywords

N(G) METHYLARGININE; PHOSPHATE; THROMBIN;

ANIMAL TISSUE; APOPTOSIS; CARTILAGE CELL; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA FRAGMENTATION; FEMALE; GROWTH PLATE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CHONDROCYTES; DNA FRAGMENTATION; FEMALE; HUMANS; NITRIC OXIDE; OMEGA-N-METHYLARGININE; PEPTIDE FRAGMENTS; PHOSPHATES; RATS;

EID: 57449110197     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000152913     Document Type: Conference Paper

References (14)

1. Adams, C.S., I.M. Shapiro (2002) The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med 13: 465-473.
2. Gibson, G. (1998) Active role of chondrocyte apoptosis in endochondral ossification. Microsc Res Tech 43: 191-204.
3. Hatori, M., K.J. Klatte, C.C. Teixeira, I.M. Shapiro (1995) End labeling studies of fragmented DNA in the avian growth plate: evidence of apoptosis in terminally differentiated chondrocytes. J Bone Miner Res 10: 1960-1968.
4. Howell, D.S., J.C. Pita, J.F. Marquez, R.A. Gatter (1969) Demonstration of macromolecular inhibitors of calcification and nucleational factors in fluid from calcifying sites in cartilage. J Clin Invest 48: 630-641.
5. Kakuta, S., E.E. Golub, I.M. Shapiro (1985) Morphochemical analysis of phosphorus pools in calcifying cartilage. Calcif Tissue Int 37: 293-299.
6. Mansfield, K., R. Rajpurohit, I.M. Shapiro (1999) Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes. J Cell Physiol 179: 276-286.
7. Ohyama, K., C. Farquharson, C.C. Whitehead, I.M. Shapiro (1997) Further observations on programmed cell death in the epiphyseal growth plate: comparison of normal and dyschondroplastic epiphyses. J Bone Miner Res 12: 1647-1656.
8. Pucci, B., C.S. Adams, J. Fertala, B.C. Snyder, K.D. Mansfield, M. Tafani, T. Freeman, I.M. Shapiro (2007) Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. J Cell Physiol 210: 609-615.
9. Schwartz, Z., D.H. Carney, R.S. Crowther, J.T. Ryaby, B.D. Boyan (2005) Thrombin peptide (TP508) treatment of rat growth plate cartilage cells promotes proliferation and retention of the chondrocytic phenotype while blocking terminal endochondral differentiation. J Cell Physiol 202: 336-343.
10. Sheller, M.R., R.S. Crowther, J.H. Kinney, J. Yang, S. Di Jorio, T. Breunig, D.H. Carney, J.T. Ryaby (2004) Repair of rabbit segmental defects with the thrombin peptide, TP508. J Orthop Res 22: 1094-1099.
11. Simmons, D.J., J. Yang, S. Yang (1998) Acceleration of rat femoral fracture healing by a synthetic thrombin peptide; in Dacke, C., J. Danks, G. Flik, C. Gay (eds): Calcium Metabolism. Bristol, BioScientifica Ltd., pp 145-152.
12. Teixeira, C.C., K. Mansfield, C. Hertkorn, H. Ischiropoulos, I.M. Shapiro (2001) Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation. Am J Physiol Cell Physiol 281: C833-C839.
13. Vortkamp, A., S. Pathi, G.M. Peretti, E.M. Caruso, D.J. Zaleske, C.J. Tabin (1998) Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 71: 65-76.
14. Zhong, M., L.J. Wike, J.T. Ryaby, D.H. Carney, B.D. Boyan, Z. Schwartz (2008) Thrombin peptide TP508 prevents nitric oxide mediated apoptosis in chondrocytes in endochondral development pathway. Biochim Biophys Acta 1783: 12-22.