The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor

Biotechnology and Bioengineering

Volumn 70, Issue 1, 2000, Pages 32-40

  Begley, Cynthia M ^a,b   Kleis, Stanley J ^a,b  

^a NASA JOHNSON SPACE CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

Bioreactor design; Low shear culture; Microcarrier; Microgravity culture; Rotating wall vessel

Indexed keywords

HYDRODYNAMICS; LASER DOPPLER VELOCIMETERS; MATHEMATICAL MODELS; MICROGRAVITY PROCESSING; SHEAR STRESS;

ROTATING-WALL VESSELS;

BIOREACTORS;

ARTICLE; ASTRONOMY; BIOREACTOR; DYNAMICS; ENVIRONMENT; FLOW; HYDRODYNAMICS; LASER DOPPLER FLOWMETRY; LIQUID; MATHEMATICAL MODEL; MICROGRAVITY; PERFUSION; ROTATING WALL PERFUSED VESSEL BIOREACTOR; ROTATION; SIMULATION; STRESS;

BIOREACTORS; CELL CULTURE; GRAVITATION; MODELS, THEORETICAL; STRESS, MECHANICAL; TIME FACTORS; WATER;

EID: 0034610089     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20001005)70:1<32::AID-BIT5>3.0.CO;2-V     Document Type: Article

References (7)

1. Hydrodnamic effects on cells in agitated tissue culture reactors
2. Tissue engineering of cartilage in space
3. Morphologic differentation of colon carcinoma cell lines HT-29 and HT-29KM in rotating wail vessels
4. Reduced shear stress: A major component in the ability of mammal ian tissues to form three-dimensional assemblies in simulated microgravity
5. A viscous pump bioreactor
6. Microcarrier cultures of animal cells