Menstrual cycle-related morphometric and vascular modifications of the clitoris

Journal of Sexual Medicine

Volumn 5, Issue 12, 2008, Pages 2853-2861

  Battaglia, Cesare ^a   Nappi, Rossella Elena ^b   Mancini, Fulvia ^a   Cianciosi, Arianna ^a   Persico, Nicola ^a   Busacchi, Paolo ^a   Facchinetti, Fabio ^c   De Aloysio, Domenico ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Clitoris; Hormones; Menstrual Cycle; MRI; Ultrasound

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRITE; SEX HORMONE BINDING PROTEIN; TESTOSTERONE;

ADULT; ANATOMY; ANDROGEN BLOOD LEVEL; ANDROSTENEDIONE BLOOD LEVEL; ARTERY BLOOD FLOW; ARTICLE; BIOCHEMISTRY; CLITORIS; CORRELATIONAL STUDY; DOPPLER FLOWMETRY; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LUTEINIZING HORMONE BLOOD LEVEL; MENSTRUAL CYCLE; MENSTRUATION; NORMAL HUMAN; ORGAN BLOOD FLOW; OVARY BLOOD FLOW; OVULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; TRANSVAGINAL ECHOGRAPHY; UTERUS BLOOD FLOW;

EID: 57449083970     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.00972.x     Document Type: Article

References (38)

1. Stanislaw H, Rice FJ. Correlation between sexual desire and menstrual cycle characteristics. Arch Sex Behav 1988;17:499-508.
2. Meuwissen I, Over R. Sexual arousal across phases of the human menstrual cycle. Arch Sex Behav 1992;21:101-19.
3. Deliganis AV, Maravilla KR, Heiman JR, Carter WO, Garland PA, Peterson BT, Hackbert L, Cao Y, Weisskoff RM. Female genitalia: Dynamic MR imaging with use of MS-325 initial experiences evaluating female sexual response. Radiology 2002;225:791-9.
4. Maravilla KR, Cao Y, Heiman JR, Yang C, Garland PA, Peterson BT, Carter WO. Noncontrast dynamic magnetic resonance imaging for quantitative assessment of female sexual arousal. J Urol 2005;173:162-6.
5. O'Connel HE, DeLancey JOL. Clitoral anatomy in nulliparous, healthy, premenopausal volunteers using unenhanced magnetic resonance imaging. J Urol 2005;173:2060-3.
6. Maravilla KR, Yang CC. Magnetic resonance imaging and the female sexual response: Overview of techniques, results, and future directions. J Sex Med 2008;5:1559-71.
7. Buisson O, Foldes P, Paniel BJ. Sonography of the clitoris. J Sex Med 2008;5:413-7.
8. Gravina GL, Brandetti F, Martini P, Carosa E, Di Stasi SM, Morano S, Lenzi A, Jannini EA. Measurement of the thickness of the urethrovaginal space in women with or without vaginal orgasm. J Sex Med 2008;5:610-8.
9. Wimpissinger F, Stifter K, Grin W, Stackl W. The female prostate revisited: Perineal ultrasound and biochemical studies of female ejaculate. J Sex Med 2007;4:1388-93.
10. Kukkonen TM, Paterson L, Binik YM, Amsel R, Bouvier F, Khalifè S. Convergent and discriminant validity of clitoral color Doppler ultrasonography as a measure of female sexual arousal. J Sex Marital Ther 2006;32:281-7.
11. Garcia S, Talakoub L, Maitland S, Dennis A, Goldstein I, Munarriz R. Genital duplex Doppler ultrasonography before and after sexual stimulation in women with sexual dysfunction: Gray scale, volumetric, and hemodynamic findings. Fertil Steril 2005;83:995-9.
12. Nappi RE, Federghini F, Sampaolo P, Vaccaro P, De Leonardis C, Albani F, Salonia A, Polatti F. Clitoral circulation in postmenopausal women with sexual dysfunction: A pilot randomized study with hormone therapy. Maturitas 2006;55:288-95.
13. Styles SJ, MacLean AB, Reid WMN, Sultana SR. Laser Doppler perfusion imaging: A method for measuring female sexual response. Br J Obstet Gynaecol 2006;113:599-601.
14. Nappi RE, Mancini M, Veneroni F, Colpi GM, Federghini F, Polatti F. Clitoral artery blood flow in healthy young women: Preliminary report on menstrual cycle and hormonal contraception. J Sex Marital Ther 2002;28(1 suppl):187-93.
15. Battaglia C, Artini PG, Salvatori M, Giulini S, Petraglia F, Maxia N, Volpe A. Ultrasonographic patterns of polycystic ovaries: Color Doppler and hormonal correlations. Ultrasound Obstet Gynecol 1998;11:332-6.
16. Battaglia C, Artini PG, D'Ambrogio G, Genazzani AD, Genazzani AR. The role of color Doppler imaging in the diagnosis of polycystic ovary syndrome. Am J Obstet Gynecol 1995;172:108-13.
17. Battaglia C, Regnani G, Marsella T, Facchinetti F, Volpe A, Venturoli S, Flamigni C. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: A double-blind, randomized study. Hum Reprod 2002;17:659-65.
18. Facchinetti F, De Martis S, Neri I, Caputo A, Volpe A. Effects of transdermal glyceryltrinitrate on 24-h blood pressure changes in patients with gestational hypertension. Prenat Neonatal Med 1997;2:22-8.
19. O'Connel HE, Sanjeevan K, Hutson JM. Anatomy of the clitoris. J Urol 2005;174:1189-95.
20. Basson R. Hormones and sexuality: Current complexities and future directions. Maturitas 2007;57:66-70.
21. Berman JR, McCarthy M, Kyprianou N. Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urol 1998;51:650-6.
22. Sarrel PM. Sexuality and menopause. Obstet Gynecol 1990;75:26S-30S.
23. Sarrel PM. Ovarian hormones and vaginal blood flow: Using laser Doppler velocimetry to measure effects in a clinical trial of post-menopausal women. Int J Impot Res 1998;10:S91-S93.
24. Schwenkhagen A. Hormonal changes in menopause and implications on sexual health. J Sex Med 2007;3:220-6.
25. Dennerstein L, Lehert P, Burger H. The relative effects of hormones and relationship factors on sexual function of women through the natural menopause. Fertil Steril 2005;64:174-80.
26. Hayashi T, Yamada K, Esaki T, Mutoh E, Iguchi A. Effect of estrogen on isoforms of nitric oxide synthase: Possible mechanism of anti-atherosclerotic effects of estrogen. Gerontology 1997;42(1 suppl):24-34.
27. Gragasin FS, Michelakis ED, Hogan A, Mougdil R, Hashimoto K, Wu X, Bonnett S, Archer SL. The neurovascular mechanism of clitoral erection: Nitric oxide and cGMP-stimulated activation of BK Ca channels. FASEB J 2004;18:1382-91.
28. Salamon E, Esch T, Stefano GB. Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release. Acta Pharmacol Sin 2005;26:389-95.
29. Salonia A, Nappi RE, Pontillo M, Daverio R, Smeraldi A, Briganti A, Fabbri F, Zanni G, Rigatti P, Montorsi F. Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Horm Behav 2005;47:164-9.
30. Slob AK, Bax CM, Hop WCJ, Rowland DL, van der Werff ten Bosch JJ. Sexual arousability and the menstrual cycle. Psychoneuroendocrinology 1996;21:545-58.
31. Traish AM, Kim N, Min K, Munarriz R, Goldstein I. Role of androgens in female genital sexual arousal: Receptor expression, structure, and function. Fertil Steril 2002;77:S11-8.
32. Traish AM, Kim SW, Stankovic M, Goldstein I, Kim NN. Testosterone increases blood flow and expression of androgen and estrogen receptors in the rat vagina. J Sex Med 2007;4:609-19.
33. Pessina MA, Hoyt RF Jr, Goldstein I, Traish AM. Differential regulation of the expression of estrogen, progesterone, and androgen receptors by sex steroid hormones in the vagina: Immunohistochemical studies. J Sex Med 2006;3:804-14.
34. Salonia A, Pontillo M, Nappi RE, Zanni G, Fabbri F, Scavini M, Daverio R, Gallina A, Rigatti P, Bosi E, Bonini PA, Montorsi F. Menstrual cycle changes in circulating androgens in healthy women with self-reported normal sexual function. J Sex Med 2008;5:854,-863.
35. Labrie F, Nelanger P, Berubè R, Martel C, Cusan L, Gomez J, Candas B, Castiel I, Chaussade V, Deloche C, Leclaire J. Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women. J Steroid Biochem Mol Biol 2006;99:182-8.
36. Davis SR, Tran J. Testosterone influences libido and well being in women. Trends Endocrinol Metab 2001;12:33-7.
37. Hodgins MB, Spike RC, Mackie RM, MacLean AB. An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina. Br J Obstet Gynaecol 1998;105:216-22.
38. Krasinski K, Spyridopoulos I, Asahara T, van der Zee R, Isner JM, Losordo DW. Estradiol accelerates functional endothelial recovery after arterial injury. Circulation 1997;95:1768-1772.