Testosterone increases blood flow and expression of androgen and estrogen receptors in the rat vagina

Journal of Sexual Medicine

Volumn 4, Issue 3, 2007, Pages 609-619

  Traish, Abdulmaged M ^a   Kim, Soo Woong ^b   Stankovic, Miljan ^a   Goldstein, Irwin ^c   Kim, Noel N ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Seoul National University College of Medicine   (South Korea)

^c ALVARADO HOSPITAL   (United States)

Author keywords

Androgen receptor; Testosterone; Vaginal blood flow

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; MACROGOL; RADIOLIGAND; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BODY WEIGHT; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONAL REGULATION; HORMONE ACTION; LASER DOPPLER FLOWMETRY; NERVE STIMULATION; NONHUMAN; OVARIECTOMY; PELVIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SEXUAL AROUSAL; TESTOSTERONE BLOOD LEVEL; UTERUS; VAGINA; VAGINA EPITHELIUM; WESTERN BLOTTING;

EID: 34249069853     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00491.x     Document Type: Article

References (42)

1. Traish AM, Kim NN. Modulation of female genital sexual arousal by sex steroid hormones. In: Goldstein I, Meston CM, Davis S, Traish AM, eds. Female sexual dysfunction - Study, diagnosis and treatment. London: Taylor & Francis; 2006: 181-92.
2. Giraldi A, Marson L, Nappi R, Pfaus J, Traish AM, Vardi Y, Goldstein I. Physiology of female sexual function: Animal models. J Sex Med 2004;1:237-53.
3. Goldstein I, Traish A, Kim N, Munarriz R. The role of sex steroid hormones in female sexual function and dysfunction. Clin Obstet Gynecol 2004;47:471-84.
4. Munarriz R, Kim SW, Kim NN, Traish A, Goldstein I. A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model. J Urol 2003;170:S40-4.
5. Min K, Munarriz R, Kim NN, Choi S, O'Connell L, Goldstein I, Traish AM. Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model. J Sex Marital Ther 2003;29:77-84.
6. Min K, Munarriz R, Kim NN, Goldstein I, Traish A. Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model. Am J Obstet Gynecol 2002;187:1370-6.
7. Kim SW, Kim NN, Jeong SJ, Munarriz R, Goldstein I, Traish AM. Modulation of rat vaginal blood flow and estrogen receptor by estradiol. J Urol 2004;172:1538-43.
8. Kim NN, Min K, Pessina MA, Munarriz R, Goldstein I, Traish AM. Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility. Int J Impot Res 2004;16:43-50.
9. Kim SW, Jeong SJ, Munarriz R, Kim NN, Goldstein I, Traish AM. An in vivo rat model to investigate female vaginal arousal response. J Urol 2004;171:1357-61.
10. Pessina MA, Hoyt RF Jr, Goldstein I, Traish AM. Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrity. Endocrinology 2006;147:61-9.
11. Jannini EA, d'Amati G, Lenzi A. Histology and immunohistochemical studies of female genital tissue. In: Goldstein I, Meston C, Davis S, Traish A, eds. Women's sexual function and dysfunction: Study, diagnosis and treatment. London: Taylor & Francis; 2006:125-33.
12. Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi KM. Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res 1997;9:27-37.
13. Drews U, Sulak O, Schenck PA. Androgens and the development of the vagina. Biol Reprod 2002;67:1353-9.
14. Forsberg JG. A morphologist's approach to the vagina - Age-related changes and estrogen sensitivity. Maturitas 1995;22:S7-15.
15. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987;49:397-409.
16. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: A prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-51.
17. Buster JE, Kingsberg SA, Aguirre O, Brown C, Breaux JG, Buch A, Rodenberg CA, Wekselman K, Casson P. Testosterone patch for low sexual desire in surgically menopausal women: A randomized trial. Obstet Gynecol 2005;105:944-52.
18. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343: 682-8.
19. Simon J, Braunstein G, Nachtigall L, Utian W, Katz M, Miller S, Waldbaum A, Bouchard C, Derzko C, Buch A, Rodenberg C, Lucas J, Davis S. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-33.
20. Braunstein GD, Sundwall DA, Katz M, Shifren JL, Buster JE, Simon JA, Bachman G, Aguirre OA, Lucas JD, Rodenberg C, Buch A, Watts NB. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-9.
21. Kennedy TG, Armstrong DT. Induction of vaginal mucification in rats with testosterone and17beta-hydroxy-5alpha-androstan-3-one. Steroids 1976;27:423-30.
22. Kennedy TG. Vaginal mucification in the ovariectomized rat in response to 5alpha-pregnane-3,20-dione, testosterone and 5alpha-androstan-17beta-ol-3-one: Test for progestogenic activity. J Endocrinol 1974;61:293-300.
23. Traish AM, Kim NN, Huang YH, Min K, Munarriz R, Goldstein I. Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vagina. Int J Impot Res 2003;15:397-404.
24. Armagan A, Kim NN, Goldstein I, Traish AM. Dose-response relationship between testosterone and erectile function: Evidence for the existence of a critical threshold. J Androl 2006;27:517-26.
25. Kim NN, Stankovic M, Armagan A, Cushman TT, Goldstein I, Traish AM. Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat. BMC Womens Health 2006;6:14 (doi: 10.1186/1472-6874-6-14).
26. Traish AM, Muller RE, Wotiz HH. A new procedure for the quantitation of nuclear and cytoplasmic androgen receptors. J Biol Chem 1981;256:12028-33.
27. Traish AM, Muller RE, Wotiz HH. Binding of estrogen receptor to uterine nuclei. Salt-extractable versus salt-resistant receptor-estrogen complexes. J Biol Chem 1977;252:6823-30.
28. Traish AM, Kim N, Min K, Munarriz R, Goldstein I. Role of androgens in female genital sexual arousal: Receptor expression, structure, and function. Fertil Steril 2002;77 (4 suppl):S11-8.
29. Davis SR, Guay AT, Shifren JL, Mazer NA. Endocrine aspects of female sexual dysfunction. J Sex Med 2004;1:82-6.
30. Goldstein I, Alexander JL. Practical aspects in the management of vaginal atrophy and sexual dysfunction in perimenopausal and postmenopausal women. J Sex Med 2005;2 (3 suppl):154-65.
31. Pessina MA, Hoyt RF, Goldstein I, Traish AM. Differential regulation of the expression of estrogen, progesterone, and androgen receptors by sex steroid hormones in the vagina: Immunohistochemical studies. J Sex Med 2006;3:804-14.
32. Burnstein KL. Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy. J Cell Biochem 2005;95:657-69.
33. Wiren KM, Zhang X, Chang C, Keenan E, Orwoll ES. Transcriptional up-regulation of the human androgen receptor by androgen in bone cells. Endocrinology 1997;138:2291-300.
34. Takeuchi M, Kakushi H, Tohkin M. Androgens directly stimulate mineralization and increase androgen receptors in human osteoblast-like osteosarcoma cells. Biochem Biophys Res Commun 1994;204:905-11.
35. Zhao H, Tian Z, Hao J, Chen B. Extragonadal aromatization increases with time after ovariectomy in rats. Reprod Biol Endocrinol 2005;3:6 (doi: 10.1186/1477-7827-3-6).
36. Lephart ED, Mathews D, Noble JF, Ojeda SR. The vaginal epithelium of immature rats metabolizes androgens through an aromatase-like reaction: Changes during the time of puberty. Biol Reprod 1989;40:259-67.
37. Berman JF, Almeida FG, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid NF. Correlation of androgen receptors, aromatase, and 5-α reductase in the human vagina with menopausal status. Fertil Steril 2003;79:925-31.
38. Geary N, Asarian L. Cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats. Physiol Behav 1999;67:141-7.
39. Mowa CN, Iwanaga T. Differential distribution of oestrogen receptor-5-α and - β mRNAs in the female reproductive organ of rats as revealed by in situ hybridization. J Endocrinol 2000;165:59-66.
40. Tuiten A, van Honk J, Verbaten R, Laan E, Everaerd W, Stam H. Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Arch Gen Psychiatry 2002;59:465-6.
41. Tuiten A, van Honk J, Koppeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 2000;57:149-53.
42. Sarrel PM. Psychosexual effects of menopause: Role of androgens. Am J Obstet Gynecol 1999;180:S319-24.