메뉴 건너뛰기




Volumn 22, Issue 1, 2009, Pages 78-89

Calcineurin-inhibitor minimization protocols in heart transplantation

Author keywords

Cardiac transplantation; Immunosuppression; Minimization; Mycophenolate mofetil; Rapamycin; Renal dysfunction

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CYCLOSPORIN A; DACLIZUMAB; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EVEROLIMUS; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

EID: 57349197312     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2008.00771.x     Document Type: Review
Times cited : (53)

References (72)
  • 1
    • 0034897948 scopus 로고    scopus 로고
    • Long-term outcomes after cardiac transplantation: An experience based on different eras of immunosuppressive therapy
    • John R, Rajasinghe HA, Chen JM, Weinberg AD, et al. Long-term outcomes after cardiac transplantation: an experience based on different eras of immunosuppressive therapy. Ann Thorac Surg 2001 72 : 440.
    • (2001) Ann Thorac Surg , vol.72 , pp. 440
    • John, R.1    Rajasinghe, H.A.2    Chen, J.M.3    Weinberg, A.D.4
  • 2
    • 34247113125 scopus 로고    scopus 로고
    • International Society for Heart and Lung Transplantation. Registry of the International Society for Heart and Lung Transplantation: Twenty-third official adult heart transplantation report-2006
    • Taylor DO, Edwards LB, Boucek MM, et al. International Society for Heart and Lung Transplantation. Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report-2006. J Heart Lung Transplant 2006 25 : 869.
    • (2006) J Heart Lung Transplant , vol.25 , pp. 869
    • Taylor, D.O.1    Edwards, L.B.2    Boucek, M.M.3
  • 3
    • 33644780091 scopus 로고    scopus 로고
    • Kidney disease after heart and lung transplantation
    • Bloom RD, Doyle AM. Kidney disease after heart and lung transplantation. Am J Transplant 2006 6 : 671.
    • (2006) Am J Transplant , vol.6 , pp. 671
    • Bloom, R.D.1    Doyle, A.M.2
  • 4
    • 0042360213 scopus 로고    scopus 로고
    • Chronic renal failure after transplantation of a nonrenal organ
    • Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003 349 : 931.
    • (2003) N Engl J Med , vol.349 , pp. 931
    • Ojo, A.O.1    Held, P.J.2    Port, F.K.3
  • 5
    • 33846253554 scopus 로고    scopus 로고
    • The outcome of heart transplant recipients following the development of end-stage renal disease: Analysis of the Canadian Organ Replacement Register (CORR)
    • Alam A, Badovinac K, Ivis F, Trpeski L, Cantarovich M. The outcome of heart transplant recipients following the development of end-stage renal disease: analysis of the Canadian Organ Replacement Register (CORR). Am J Transplant 2007 7 : 461.
    • (2007) Am J Transplant , vol.7 , pp. 461
    • Alam, A.1    Badovinac, K.2    Ivis, F.3    Trpeski, L.4    Cantarovich, M.5
  • 6
    • 1042304235 scopus 로고    scopus 로고
    • End-stage renal failure and cardiac mortality after heart transplantation
    • Senechal M, Dorent R, du Montcel ST, et al. End-stage renal failure and cardiac mortality after heart transplantation. Clin Transplant 2004 18 : 1.
    • (2004) Clin Transplant , vol.18 , pp. 1
    • Senechal, M.1    Dorent, R.2    Du Montcel, S.T.3
  • 7
    • 0023281349 scopus 로고
    • Results of immunoconversion from cyclosporine to azathioprine in heart transplant recipients with progressive nephrotoxicity
    • Hunt S, Stinson E, Oyer P, et al. Results of immunoconversion from cyclosporine to azathioprine in heart transplant recipients with progressive nephrotoxicity. Transplant Proc 1987 19 : 2522.
    • (1987) Transplant Proc , vol.19 , pp. 2522
    • Hunt, S.1    Stinson, E.2    Oyer, P.3
  • 8
    • 20244388105 scopus 로고    scopus 로고
    • A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators
    • Kobashigawa J, Miller L, Renlund D, et al. A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation 1998 66 : 507.
    • (1998) Transplantation , vol.66 , pp. 507
    • Kobashigawa, J.1    Miller, L.2    Renlund, D.3
  • 9
    • 20844461132 scopus 로고    scopus 로고
    • Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: A randomized clinical trial
    • Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 2004 110 : 2694.
    • (2004) Circulation , vol.110 , pp. 2694
    • Keogh, A.1    Richardson, M.2    Ruygrok, P.3
  • 10
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    • Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 2003 349 : 847.
    • (2003) N Engl J Med , vol.349 , pp. 847
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3
  • 11
    • 33745393847 scopus 로고    scopus 로고
    • Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report
    • Kobashigawa JA, Miller LW, Russell SD, et al. Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant 2006 6 : 1377.
    • (2006) Am J Transplant , vol.6 , pp. 1377
    • Kobashigawa, J.A.1    Miller, L.W.2    Russell, S.D.3
  • 12
    • 24344487987 scopus 로고    scopus 로고
    • Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation
    • Rosenberg PB, Vriesendorp AE, Drazner MH, et al. Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation. J Heart Lung Transplant 2005 24 : 1327.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1327
    • Rosenberg, P.B.1    Vriesendorp, A.E.2    Drazner, M.H.3
  • 13
    • 4544325560 scopus 로고    scopus 로고
    • Antithymocyte globulin induction allows a prolonged delay in the initiation of cyclosporine in heart transplant patients with postoperative renal dysfunction
    • Cantarovich M, Giannetti N, Barkun J, Cecere R. Antithymocyte globulin induction allows a prolonged delay in the initiation of cyclosporine in heart transplant patients with postoperative renal dysfunction. Transplantation 2004 78 : 779.
    • (2004) Transplantation , vol.78 , pp. 779
    • Cantarovich, M.1    Giannetti, N.2    Barkun, J.3    Cecere, R.4
  • 15
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall MD, et al. Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006 6 : 514.
    • (2006) Am J Transplant , vol.6 , pp. 514
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.D.3
  • 16
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus, and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and meta-analysis of randomized trials
    • Webster AC, Lee VWS, Chapman JR, Craig JC. Target of rapamycin inhibitors (sirolimus, and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation 2006 81 : 1234.
    • (2006) Transplantation , vol.81 , pp. 1234
    • Webster, A.C.1    Lee, V.W.S.2    Chapman, J.R.3    Craig, J.C.4
  • 17
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007 357 : 2562.
    • (2007) N Engl J Med , vol.357 , pp. 2562
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 18
    • 16244393063 scopus 로고    scopus 로고
    • First experience with de novo calcineurin-inhibitor-free immunosuppression following cardiac transplantation
    • Meiser B, Reichart B, Adamidis I, Uberfuhr P, Kaczmarek I. First experience with de novo calcineurin-inhibitor-free immunosuppression following cardiac transplantation. Am J Transplant 2005 1 : 827.
    • (2005) Am J Transplant , vol.1 , pp. 827
    • Meiser, B.1    Reichart, B.2    Adamidis, I.3    Uberfuhr, P.4    Kaczmarek, I.5
  • 19
    • 33645370770 scopus 로고    scopus 로고
    • Sirolimus in de novo heart transplant recipients with severe renal impairment
    • Vazquez de Prada JA, Vilchez FG, Cobo M, et al. Sirolimus in de novo heart transplant recipients with severe renal impairment. Transpl Int 2006 19 : 245.
    • (2006) Transpl Int , vol.19 , pp. 245
    • Vazquez De Prada, J.A.1    Vilchez, F.G.2    Cobo, M.3
  • 20
    • 21244490121 scopus 로고    scopus 로고
    • Daclizumab to prevent rejection after cardiac transplantation
    • Hershberger RE, Starling RC, Eisen HJ, et al. Daclizumab to prevent rejection after cardiac transplantation. N Engl J Med 2005 352 : 2705.
    • (2005) N Engl J Med , vol.352 , pp. 2705
    • Hershberger, R.E.1    Starling, R.C.2    Eisen, H.J.3
  • 21
    • 24344508163 scopus 로고    scopus 로고
    • A multicenter, prospective, randomized, double-blind trial of basiliximab in heart transplantation
    • Mehra MR, Zucker MJ, Wagoner L, et al. A multicenter, prospective, randomized, double-blind trial of basiliximab in heart transplantation. J Heart Lung Transplant 2005 24 : 1297.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1297
    • Mehra, M.R.1    Zucker, M.J.2    Wagoner, L.3
  • 22
    • 0037090873 scopus 로고    scopus 로고
    • Anti-CD25 monoclonal antibody coverage allows for calcineurin inhibitor "holiday" in solid organ transplant patients with acute renal dysfunction
    • Cantarovich M, Metrakos P, Giannetti N, Cecere R, Barkun J, Tchervenkov J. Anti-CD25 monoclonal antibody coverage allows for calcineurin inhibitor "holiday" in solid organ transplant patients with acute renal dysfunction. Transplantation 2002 73 : 1169.
    • (2002) Transplantation , vol.73 , pp. 1169
    • Cantarovich, M.1    Metrakos, P.2    Giannetti, N.3    Cecere, R.4    Barkun, J.5    Tchervenkov, J.6
  • 23
    • 23744511695 scopus 로고    scopus 로고
    • Long-term calcineurin inhibitor "holiday" using daclizumab in a heart transplant patient with acute renal dysfunction
    • Potter B, Giannetti N, Cecere R, Cantarovich M. Long-term calcineurin inhibitor "holiday" using daclizumab in a heart transplant patient with acute renal dysfunction. J Heart Lung Transplant 2005 24 : 1126.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1126
    • Potter, B.1    Giannetti, N.2    Cecere, R.3    Cantarovich, M.4
  • 24
    • 33846871197 scopus 로고    scopus 로고
    • Renal protective strategies in heart transplant patients
    • Cantarovich M. Renal protective strategies in heart transplant patients. Curr Opin Cardiol 2007 22 : 133.
    • (2007) Curr Opin Cardiol , vol.22 , pp. 133
    • Cantarovich, M.1
  • 25
    • 0034720036 scopus 로고    scopus 로고
    • Improvement of impaired renal function in heart transplant recipients treated with mycophenolate mofetil and low-dose cyclosporine
    • Aleksic I, Baryalei M, Busch T, et al. Improvement of impaired renal function in heart transplant recipients treated with mycophenolate mofetil and low-dose cyclosporine. Transplantation 2000 69 : 1586.
    • (2000) Transplantation , vol.69 , pp. 1586
    • Aleksic, I.1    Baryalei, M.2    Busch, T.3
  • 26
    • 0036753579 scopus 로고    scopus 로고
    • Reversal of chronic cyclosporine nephrotoxicity after heart transplantation-potential role of mycophenolate mofetil
    • Tedoriya T, Keogh AM, Kusano K, et al. Reversal of chronic cyclosporine nephrotoxicity after heart transplantation-potential role of mycophenolate mofetil. J Heart Lung Transplant 2002 21 : 976.
    • (2002) J Heart Lung Transplant , vol.21 , pp. 976
    • Tedoriya, T.1    Keogh, A.M.2    Kusano, K.3
  • 27
    • 0038772397 scopus 로고    scopus 로고
    • Renal function and safety of heart transplant recipients switched to mycophenolate mofetil and low-dose cyclosporine
    • Baryalei M, Zenker D, Pieske B, Tondo K, Dalichau H, Aleksic I. Renal function and safety of heart transplant recipients switched to mycophenolate mofetil and low-dose cyclosporine. Transplant Proc 2003 35 : 1539.
    • (2003) Transplant Proc , vol.35 , pp. 1539
    • Baryalei, M.1    Zenker, D.2    Pieske, B.3    Tondo, K.4    Dalichau, H.5    Aleksic, I.6
  • 28
    • 0011236968 scopus 로고    scopus 로고
    • Benefit of mycophenolate-mofetil (MMF) in patients with cyclosporine (CYA) induced nephropathy after cardiac transplantation
    • Zuckermann A, Ploner M, Keziban U, et al. Benefit of mycophenolate- mofetil (MMF) in patients with cyclosporine (CYA) induced nephropathy after cardiac transplantation. J Heart Lung Transplant 2001 20 : 163.
    • (2001) J Heart Lung Transplant , vol.20 , pp. 163
    • Zuckermann, A.1    Ploner, M.2    Keziban, U.3
  • 29
    • 11144256280 scopus 로고    scopus 로고
    • Chronic cyclosporine-induced nephrotoxiciy in heart transplant patients: Long-term benefits of treatment with mycophenolate mofetil and low-dose cyclosporine
    • Sanchez V, Delgado JF, Morales JM, et al. Chronic cyclosporine-induced nephrotoxiciy in heart transplant patients: long-term benefits of treatment with mycophenolate mofetil and low-dose cyclosporine. Transplant Proc 2004 36 : 2823.
    • (2004) Transplant Proc , vol.36 , pp. 2823
    • Sanchez, V.1    Delgado, J.F.2    Morales, J.M.3
  • 30
    • 19544388738 scopus 로고    scopus 로고
    • Improvement of renal function in pediatric heart transplant recipients treated with low-dose calcineurin inhibitor and mycophenolate mofetil
    • Boyer O, Le Bidois J, Dechaux M, Gubler MC, Niaudet P. Improvement of renal function in pediatric heart transplant recipients treated with low-dose calcineurin inhibitor and mycophenolate mofetil. Transplantation 2005 79 : 1405.
    • (2005) Transplantation , vol.79 , pp. 1405
    • Boyer, O.1    Le Bidois, J.2    Dechaux, M.3    Gubler, M.C.4    Niaudet, P.5
  • 31
    • 19044362279 scopus 로고    scopus 로고
    • Heart transplant recipient clinical profile improvement following mycophenolate mofetil late incorporation into the treatment schedule
    • Manito N, Kaplinsky EJ, Roca J, et al. Heart transplant recipient clinical profile improvement following mycophenolate mofetil late incorporation into the treatment schedule. Clin Transplant 2005 19 : 304.
    • (2005) Clin Transplant , vol.19 , pp. 304
    • Manito, N.1    Kaplinsky, E.J.2    Roca, J.3
  • 32
    • 33645842225 scopus 로고    scopus 로고
    • Preliminary experience with mycophenolate mofetil for preservation of renal function in cardiac transplant patients with documented cyclosporine nephrotoxicity
    • Al-Aly Z, Sachdeva A, Philoctete Ashley JM, Bastani B. Preliminary experience with mycophenolate mofetil for preservation of renal function in cardiac transplant patients with documented cyclosporine nephrotoxicity. Nephrology 2006 11 : 151.
    • (2006) Nephrology , vol.11 , pp. 151
    • Al-Aly, Z.1    Sachdeva, A.2    Philoctete Ashley, J.M.3    Bastani, B.4
  • 33
    • 20844432212 scopus 로고    scopus 로고
    • Reduction of cyclosporine after introduction of mycophenolate mofetil improves chronic renal dysfunction in heart transplant recipients - The IMPROVED multi-centre study
    • Angermann CE, Störk S, Costard-Jäckle A, et al. Reduction of cyclosporine after introduction of mycophenolate mofetil improves chronic renal dysfunction in heart transplant recipients - the IMPROVED multi-centre study. Eur Heart J 2004 25 : 1626.
    • (2004) Eur Heart J , vol.25 , pp. 1626
    • Angermann, C.E.1    Störk, S.2    Costard-Jäckle, A.3
  • 34
    • 33947322341 scopus 로고    scopus 로고
    • Mycophenolate mofetil may allow cyclosporine and steroid sparing in de novo heart transplant patients
    • Hamour IM, Lyster HS, Burke MM, Rose ML, Banner NR. Mycophenolate mofetil may allow cyclosporine and steroid sparing in de novo heart transplant patients. Transplantation 2007 83 : 570.
    • (2007) Transplantation , vol.83 , pp. 570
    • Hamour, I.M.1    Lyster, H.S.2    Burke, M.M.3    Rose, M.L.4    Banner, N.R.5
  • 35
    • 34249317220 scopus 로고    scopus 로고
    • Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious
    • Meiser B, Kaczmarek I, Mueller M, et al. Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious. J Heart Lung Transplant 2007 26 : 598.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 598
    • Meiser, B.1    Kaczmarek, I.2    Mueller, M.3
  • 36
    • 34347233810 scopus 로고    scopus 로고
    • Observational study with everolimus (Certican) in combination with low-dose cyclosporine in de novo heart transplant recipients
    • Lehmkuhl HB, Mai D, Dandel M, et al. Observational study with everolimus (Certican) in combination with low-dose cyclosporine in de novo heart transplant recipients. J Heart Lung Transplant 2007 26 : 700.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 700
    • Lehmkuhl, H.B.1    Mai, D.2    Dandel, M.3
  • 37
    • 3042680078 scopus 로고    scopus 로고
    • First experience with rapamycin-based immunosuppression to improve kidney function after heart transplantation
    • Trösch F, Rothenburger M, Schneider M, et al. First experience with rapamycin-based immunosuppression to improve kidney function after heart transplantation. Thorac Cardiovasc Surg 2004 52 : 163.
    • (2004) Thorac Cardiovasc Surg , vol.52 , pp. 163
    • Trösch, F.1    Rothenburger, M.2    Schneider, M.3
  • 38
    • 33646404334 scopus 로고    scopus 로고
    • Everolimus and reduced cyclosporine trough levels in maintenance heart transplant recipients
    • Schweiger M, Wasler A, Prenner G, et al. Everolimus and reduced cyclosporine trough levels in maintenance heart transplant recipients. Transpl Immunol 2006 16 : 46.
    • (2006) Transpl Immunol , vol.16 , pp. 46
    • Schweiger, M.1    Wasler, A.2    Prenner, G.3
  • 39
    • 33646138493 scopus 로고    scopus 로고
    • Early renal benefit of rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients
    • Balfour IC, Srun SW, Wood EG, Belsha CW, Marshall DL, Ferdman BR. Early renal benefit of rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients. J Heart Lung Transplant 2006 25 : 518.
    • (2006) J Heart Lung Transplant , vol.25 , pp. 518
    • Balfour, I.C.1    Srun, S.W.2    Wood, E.G.3    Belsha, C.W.4    Marshall, D.L.5    Ferdman, B.R.6
  • 40
    • 38949126946 scopus 로고    scopus 로고
    • Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients
    • Ross H, Pflugfelder P, Haddad H, et al. Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients. J Heart Lung Transplant 2008 27 : 197.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 197
    • Ross, H.1    Pflugfelder, P.2    Haddad, H.3
  • 41
    • 29544442185 scopus 로고    scopus 로고
    • Everolimus (certican) in heart transplantation: Optimizing renal function through minimizing cyclosporine exposure
    • Lehmkuhl H, Ross H, Eisen H, Valantine H. Everolimus (certican) in heart transplantation: optimizing renal function through minimizing cyclosporine exposure. Transplant Proc 2005 37 : 4145.
    • (2005) Transplant Proc , vol.37 , pp. 4145
    • Lehmkuhl, H.1    Ross, H.2    Eisen, H.3    Valantine, H.4
  • 42
    • 38949125143 scopus 로고    scopus 로고
    • Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation
    • Zuckermann A, Manito N, Epailly E, et al. Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation. J Heart Lung Transplant 2008 27 : 141.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 141
    • Zuckermann, A.1    Manito, N.2    Epailly, E.3
  • 43
    • 33947681290 scopus 로고    scopus 로고
    • Recommendations for the use of everolimus (Certican) in heart transplantation: Results from the second German-Austrian Certican Consensus Conference
    • Rothenburger M, Zuckermann A, Bara C, et al. Recommendations for the use of everolimus (Certican) in heart transplantation: results from the second German-Austrian Certican Consensus Conference. J Heart Lung Transplant 2007 26 : 305.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 305
    • Rothenburger, M.1    Zuckermann, A.2    Bara, C.3
  • 44
    • 0033611084 scopus 로고    scopus 로고
    • Clinical benefit of neoral dose monitoring with cyclosporine 2-hr post-dose levels compared with trough levels in stable heart transplant patients
    • Cantarovich M, Elstein E, de Varennes B, Barkun JS. Clinical benefit of neoral dose monitoring with cyclosporine 2-hr post-dose levels compared with trough levels in stable heart transplant patients. Transplantation 1999 68 : 1839.
    • (1999) Transplantation , vol.68 , pp. 1839
    • Cantarovich, M.1    Elstein, E.2    De Varennes, B.3    Barkun, J.S.4
  • 45
    • 0031863345 scopus 로고    scopus 로고
    • Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy
    • Cantarovich M, Besner JG, Barkun JS, Elstein E, Loertscher R. Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy. Clin Transplant 1998 12 : 243.
    • (1998) Clin Transplant , vol.12 , pp. 243
    • Cantarovich, M.1    Besner, J.G.2    Barkun, J.S.3    Elstein, E.4    Loertscher, R.5
  • 46
    • 34250828036 scopus 로고    scopus 로고
    • De novo C2 monitoring immediately after cardiac transplantation is not associated with improved renal function
    • Kittleson M, Skye A, Felker G, et al. De novo C2 monitoring immediately after cardiac transplantation is not associated with improved renal function. J Heart Lung Transplant 2006 25 : S127.
    • (2006) J Heart Lung Transplant , vol.25
    • Kittleson, M.1    Skye, A.2    Felker, G.3
  • 47
    • 0038640933 scopus 로고    scopus 로고
    • Impact of cyclosporine 2-h level and mycophenolate mofetil dose on clinical outcomes in de novo heart transplant patients receiving anti-thymocyte globulin induction
    • Cantarovich M, Giannetti N, Cecere R. Impact of cyclosporine 2-h level and mycophenolate mofetil dose on clinical outcomes in de novo heart transplant patients receiving anti-thymocyte globulin induction. Clin Transplant 2003 17 : 144.
    • (2003) Clin Transplant , vol.17 , pp. 144
    • Cantarovich, M.1    Giannetti, N.2    Cecere, R.3
  • 48
    • 33646123088 scopus 로고    scopus 로고
    • Cyclosporine profiling with C2 and C0 monitoring improves outcomes after heart transplantation
    • Barnard JB, Thekkudan J, Richardson S, et al. Cyclosporine profiling with C2 and C0 monitoring improves outcomes after heart transplantation. J Heart Lung Transplant 2006 25 : 564.
    • (2006) J Heart Lung Transplant , vol.25 , pp. 564
    • Barnard, J.B.1    Thekkudan, J.2    Richardson, S.3
  • 49
    • 42149161056 scopus 로고    scopus 로고
    • Benefit of neoral C2 monitoring in de novo cardiac transplant recipients receiving basiliximab induction
    • Cantarovich M, Ross H, Arizón JM, et al. Benefit of neoral C2 monitoring in de novo cardiac transplant recipients receiving basiliximab induction. Transplantation 2008 85 : 992.
    • (2008) Transplantation , vol.85 , pp. 992
    • Cantarovich, M.1    Ross, H.2    Arizón, J.M.3
  • 50
    • 57349125790 scopus 로고    scopus 로고
    • Everolimus in de novo heart transplant recipients six month data on cyclosporine reduction and impact on renal function
    • Keogh A, Wang SS, Zuckermann A, et al. Everolimus in de novo heart transplant recipients six month data on cyclosporine reduction and impact on renal function. J Heart Lung Transplant 2007 26 : S202.
    • (2007) J Heart Lung Transplant , vol.26
    • Keogh, A.1    Wang, S.S.2    Zuckermann, A.3
  • 51
    • 0033611084 scopus 로고    scopus 로고
    • Clinical benefit of neoral dose monitoring with cyclosporine 2-hr post-dose levels compared with trough levels in stable heart transplant patients
    • Cantarovich M, Elstein E, de Varennes B, Barkun JS. Clinical benefit of neoral dose monitoring with cyclosporine 2-hr post-dose levels compared with trough levels in stable heart transplant patients. Transplantation 1999 68 : 1839.
    • (1999) Transplantation , vol.68 , pp. 1839
    • Cantarovich, M.1    Elstein, E.2    De Varennes, B.3    Barkun, J.S.4
  • 52
    • 29144516668 scopus 로고    scopus 로고
    • A randomized, controlled trial of C0- Vs C2-guided therapeutic drug monitoring of cyclosporine in stable heart transplant patients
    • Mathias HC, Ozalp F, Will MB, et al. A randomized, controlled trial of C0- Vs C2-guided therapeutic drug monitoring of cyclosporine in stable heart transplant patients. J Heart Lung Transplant 2005 24 : 2137.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 2137
    • Mathias, H.C.1    Ozalp, F.2    Will, M.B.3
  • 53
    • 34848852917 scopus 로고    scopus 로고
    • Premature Termination of a Prospective, Open Label, Randomized, Multicenter Study of Srl to Replace CNIs (CNI) in a Standard Care Regimen of CNI, MMF and Corticosteroids Early after Heart Transplantation
    • Hunt J, Bedánová H, Starling RC, et al. Premature Termination of a Prospective, Open Label, Randomized, Multicenter Study of Srl to Replace CNIs (CNI) in a Standard Care Regimen of CNI, MMF and Corticosteroids Early after Heart Transplantation. J Heart Lung Transplant 2007 26 (2S S203.
    • (2007) J Heart Lung Transplant , vol.26 , Issue.2
    • Hunt, J.1    Bedánová, H.2    Starling, R.C.3
  • 54
    • 0036253476 scopus 로고    scopus 로고
    • Sirolimus allows renal recovery in lung and heart transplant recipients with chronic renal impairment
    • Snell GI, Levvey BJ, Chin W, et al. Sirolimus allows renal recovery in lung and heart transplant recipients with chronic renal impairment. J Heart Lung Transplant 2002 21 : 540.
    • (2002) J Heart Lung Transplant , vol.21 , pp. 540
    • Snell, G.I.1    Levvey, B.J.2    Chin, W.3
  • 55
    • 10744231167 scopus 로고    scopus 로고
    • Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failure
    • Groetzner J, Meiser B, Landwehr P, et al. Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failure. Transplantation 2004 77 : 568.
    • (2004) Transplantation , vol.77 , pp. 568
    • Groetzner, J.1    Meiser, B.2    Landwehr, P.3
  • 56
    • 0141838720 scopus 로고    scopus 로고
    • Deterioration of renal function after replacement of cyclosporine with sirolimus in five patients with severe renal impairment late after heart transplantation
    • Zakliczynski M, Nozynski J, Zakliczynska H, Rozentryt P, Zembala M. Deterioration of renal function after replacement of cyclosporine with sirolimus in five patients with severe renal impairment late after heart transplantation. Transplant Proc 2003 35 : 2331.
    • (2003) Transplant Proc , vol.35 , pp. 2331
    • Zakliczynski, M.1    Nozynski, J.2    Zakliczynska, H.3    Rozentryt, P.4    Zembala, M.5
  • 57
    • 21244454092 scopus 로고    scopus 로고
    • Initial experience with sirolimus and mycophenolate mofetil for renal rescue from cyclosporine nephrotoxicity after heart transplantation
    • Lyster H, Panicker G, Leaver N, Banner NR. Initial experience with sirolimus and mycophenolate mofetil for renal rescue from cyclosporine nephrotoxicity after heart transplantation. Transplant Proc 2004 36 : 3167.
    • (2004) Transplant Proc , vol.36 , pp. 3167
    • Lyster, H.1    Panicker, G.2    Leaver, N.3    Banner, N.R.4
  • 58
    • 33748772240 scopus 로고    scopus 로고
    • Switch from cyclosporine to sirolimus as a treatment of acute renal failure complicating cardiogenic shock in a heart transplant recipient
    • Bestetti RB, Theodoropoulos TA, Burdmann EA, Santos MA, Abbud-Filho M. Switch from cyclosporine to sirolimus as a treatment of acute renal failure complicating cardiogenic shock in a heart transplant recipient. Int J Cardiol 2006 112 : 83.
    • (2006) Int J Cardiol , vol.112 , pp. 83
    • Bestetti, R.B.1    Theodoropoulos, T.A.2    Burdmann, E.A.3    Santos, M.A.4    Abbud-Filho, M.5
  • 60
    • 20344387487 scopus 로고    scopus 로고
    • Preservation of renal function after heart transplantation: Initial single-center experience with sirolimus
    • De Meester JM, Van Vlem B, Walravens M, et al. Preservation of renal function after heart transplantation: initial single-center experience with sirolimus. Transplant Proc 2005 37 : 1835.
    • (2005) Transplant Proc , vol.37 , pp. 1835
    • De Meester, J.M.1    Van Vlem, B.2    Walravens, M.3
  • 61
    • 33750625562 scopus 로고    scopus 로고
    • Sirolimus experience in heart transplantation
    • Aranda-Dios A, Lage E, Sobrino JM, et al. Sirolimus experience in heart transplantation. Transplant Proc 2006 38 : 2547.
    • (2006) Transplant Proc , vol.38 , pp. 2547
    • Aranda-Dios, A.1    Lage, E.2    Sobrino, J.M.3
  • 63
    • 34548696864 scopus 로고    scopus 로고
    • MTor Inhibitors and their secondary effects in cardiac transplant recipients: A descriptive study
    • Moro J, Almenar L, Martinez-Dolz L, et al. mTor Inhibitors and their secondary effects in cardiac transplant recipients: a descriptive study. Transplant Proc 2007 39 : 2365.
    • (2007) Transplant Proc , vol.39 , pp. 2365
    • Moro, J.1    Almenar, L.2    Martinez-Dolz, L.3
  • 64
    • 29144480970 scopus 로고    scopus 로고
    • Sirolimus in cardiac transplantation: Use as a primary immunosuppressant in calcineurin inhibitor-induced nephrotoxicity
    • Kushwaha SS, Khalpey Z, Frantz RP, et al. Sirolimus in cardiac transplantation: use as a primary immunosuppressant in calcineurin inhibitor-induced nephrotoxicity. J Heart Lung Transplant 2005 24 : 2129.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 2129
    • Kushwaha, S.S.1    Khalpey, Z.2    Frantz, R.P.3
  • 65
    • 27844587421 scopus 로고    scopus 로고
    • Improvement of renal dysfunction by conversion from calcineurin inhibitors to sirolimus after heart transplantation
    • Hunt J, Lerman M, Magee MJ, Dewey TM, Herbert M, Mack MJ. Improvement of renal dysfunction by conversion from calcineurin inhibitors to sirolimus after heart transplantation. J Heart Lung Transplant 2005 24 : 1863.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1863
    • Hunt, J.1    Lerman, M.2    Magee, M.J.3    Dewey, T.M.4    Herbert, M.5    MacK, M.J.6
  • 66
    • 33750011166 scopus 로고    scopus 로고
    • Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy
    • Gleissner CA, Doesch A, Ehlermann P, et al. Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy. Am J Transplant 2006 6 : 2750.
    • (2006) Am J Transplant , vol.6 , pp. 2750
    • Gleissner, C.A.1    Doesch, A.2    Ehlermann, P.3
  • 67
    • 33847375217 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free immunosuppression using everolimus (Certican) in maintenance heart transplant recipients: 6 months' follow-up
    • Rothenburger M, Teerling E, Bruch C, et al. Calcineurin inhibitor-free immunosuppression using everolimus (Certican) in maintenance heart transplant recipients: 6 months' follow-up. J Heart Lung Transplant 2007 26 : 250.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 250
    • Rothenburger, M.1    Teerling, E.2    Bruch, C.3
  • 68
    • 34848874138 scopus 로고    scopus 로고
    • Sirolimus-based immunosuppression after cardiac transplantation: Predictors of recovery from calcineurin inhibitor-induced renal dysfunction
    • Gustafsson F, Ross HJ, Delgado MS, Bernabeo G, Delgado DH. Sirolimus-based immunosuppression after cardiac transplantation: predictors of recovery from calcineurin inhibitor-induced renal dysfunction. J Heart Lung Transplant 2007 26 : 998.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 998
    • Gustafsson, F.1    Ross, H.J.2    Delgado, M.S.3    Bernabeo, G.4    Delgado, D.H.5
  • 69
    • 34548182861 scopus 로고    scopus 로고
    • Replacement of calcineurin-inhibitors with sirolimus as primary immunosuppression in stable cardiac transplant recipients
    • Raichlin E, Khalpey Z, Kremers W, et al. Replacement of calcineurin-inhibitors with sirolimus as primary immunosuppression in stable cardiac transplant recipients. Transplantation 2007 84 : 467.
    • (2007) Transplantation , vol.84 , pp. 467
    • Raichlin, E.1    Khalpey, Z.2    Kremers, W.3
  • 70
    • 40449101061 scopus 로고    scopus 로고
    • Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients
    • Aliabadi AZ, Pohanka E, Seebacher G, et al. Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. Am J Transplant 2008 8 : 854.
    • (2008) Am J Transplant , vol.8 , pp. 854
    • Aliabadi, A.Z.1    Pohanka, E.2    Seebacher, G.3
  • 71
    • 0038300674 scopus 로고    scopus 로고
    • Use of rapamycin slows progression of cardiac transplantation vasculopathy
    • Mancini D, Pinney S, Burkhoff D, et al. Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation 2003 108 : 48.
    • (2003) Circulation , vol.108 , pp. 48
    • Mancini, D.1    Pinney, S.2    Burkhoff, D.3
  • 72
    • 37349072494 scopus 로고    scopus 로고
    • Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation
    • Raichlin E, Bae JH, Khalpey Z, et al. Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation. Circulation 2007 116 : 2726.
    • (2007) Circulation , vol.116 , pp. 2726
    • Raichlin, E.1    Bae, J.H.2    Khalpey, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.