A randomized, controlled trial of C0- Vs C2-guided therapeutic drug monitoring of cyclosporine in stable heart transplant patients

Journal of Heart and Lung Transplantation

Volumn 24, Issue 12, 2005, Pages 2137-2143

  Mathias, Helen C ^a   Ozalp, Farük ^a   Will, Malcolm B ^a   Borland, William ^b   Payne, Carol ^a   Kerr, Myra ^a   Lockhart, Jane ^a   Murday, Andrew J ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ADULT; ARTICLE; BLOOD SAMPLING; BLOOD TESTIS BARRIER; CARDIAC GRAFT REJECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG MONITORING; DRUG STABILITY; FEMALE; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION; INTERMETHOD COMPARISON; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

AGED; AREA UNDER CURVE; CREATININE; CYCLOSPORINE; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFECTION; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 29144516668     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2005.04.019     Document Type: Article

References (21)

1. P. Morris Cyclosporin A Transplantation 32 1981 349
2. D.O. Taylor, L.B. Edwards, M.M. Boucek, E.P. Trulock, B.M. Keck, M.I. Hertz The registry of the International Society for Heart and Lung Transplantation twenty-first official adult heart transplant report - 2004 J Heart Lung Transplant 23 2004 796 803
3. D.K. Satchithananda, J. Parameshwar, L. Sharples The incidence of end-stage renal failure in 17 years of heart transplantation a single center experience J Heart Lung Transplant 21 2002 651 657
4. D.J. Goldstein, N. Zuech, V. Sehgal, A.D. Weinberg, R. Drusin, D. Cohen Cyclosporin-associated end-stage nephropathy after cardiac transplantation incidence and progression Transplantation 63 1997 664 668
5. P. Keown, D. Landsberg, P. Halloran A randomized, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulsion in stable renal graft recipients Transplantation 62 1996 1744 1752
6. P. Keown, B.D. Kahan, A. Johnston Optimization of cyclosporine therapy with new theraputic drug monitoring strategies report from the International Neoral TDM Advisory Consensus Meeting Transplant Proc 30 1998 1645 1649
7. P.F. Halloran New strategies for the theraputic drug monitoring of Neoral 1998 Blackwell London
8. M. Cantarovich, J.G. Besner, J.S. Barkun, E. Elstein, R. Loertscher Two hour cyclosporin level determination is the appropriate tool to monitor Neoral therapy Clin Transplant 12 1998 243
9. G.A. Levy C2 monitoring strategy for optimising cyclosporine immunsuppression from the Neoral formulation Biodrugs 15 2001 279 290
10. P. Halloran, L. Helms, L. Kung, J. Noujaim The temporal profile of calcineurin inhibition by cyclosporin in vivo Transplantation 68 1999 1356 1361
11. C.M. Stein, J.J. Murray, A.J.J. Wood Inhibition of stimulated interleukin-2 production in whole blood a practical measure of cyclosporin effect Clin Chem 45 1999 1477 1484
12. A. Johnston, O.J. David, G.F. Cooney Pharmacokinetic validation of Neoral absorption profiling Transplant Proc 32 suppl 2000 53S 56S
13. M. Cantarovich, E. Elstein, B. de Varennes, J.S. Barkun Clinical benefit of Neoral dose monitoring with cyclosporin 2-hour post-dose levels compared with trough levels in stable heart transplant patients Transplantation 68 1999 1839 1842
14. G. Levy, P. Burra, A. Cavallari Improved clinical outcomes for liver transplant recipients using cyclosporin monitoring based on 2-hour postdose levels Transplantation 73 2002 953 959
15. 2 monitoring in clinical practice Transplantation 73 suppl 2002 S19 S22
16. 2 in liver transplant recipients Transplant Proc 33 2001 3089 3091
17. M. Cantarovich, J. Barkun, J. Tchervenkov Comparison of Neoral dose monitoring with cyclosporine trough levels versus 2-hr postdose levels in stable liver transplant patients Transplantation 66 1998 1621 1627
18. S. Evans, P. Royston, S. Day MINIM allocation by minimisation in clinical trials 2002
19. D.W. Cockroft, H. Gault Prediction of creatinine clearance from serum creatinine Nephron 16 1976 31
20. 2 monitoring an international consensus statement Transplantation 73 suppl 2002 S12 S18
21. P. Keown, B. Kiberd, R. Baishaw Neoral C2 monitoring in renal transplantation a cost effective tool for improving graft survival 2001 Proceedings of the European Society of Transplantation, October