Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat

Journal of Clinical Gastroenterology

Volumn 27, Issue SUPPL. 1, 1998, Pages

  Brzozowski, Tomasz ^a   Konturek, Peter Ch ^b   Konturek, Stanislaw J ^b   Kwiecień, Slawomir ^b   Pajdo, Robert ^b   Brzozowska, Iwona ^b   Hahn, Eckhart G ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b NONE

Author keywords

CCK A receptor; Cholecystokinin; Gastric mucosal blood flow; Gastroprotection; Loxiglumide; Nitric oxide; Pancreatic biliary diversion; Sensory nerves

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; INDOMETACIN; LOXIGLUMIDE; N(G) NITROARGININE METHYL ESTER; OLEATE SODIUM; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DUODENUM; HORMONE RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; SENSORY NERVE; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCOSA INJURY; STOMACH PROTECTION;

ANIMALS; CAPSAICIN; CHOLECYSTOKININ; DENERVATION; DINOPROSTONE; DOPAMINE AGENTS; ENZYME INHIBITORS; GASTRIC ACID; GASTRIC MUCOSA; HORMONE ANTAGONISTS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OLEIC ACID; PEPSIN A; PROGLUMIDE; RATS; RATS, WISTAR; RECEPTOR, CHOLECYSTOKININ A; RECEPTORS, CHOLECYSTOKININ; SINCALIDE; SOMATOSTATIN; STOMACH ULCER; VAGOTOMY;

EID: 0032445158     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-199800001-00020     Document Type: Conference Paper

References (34)

1. Meyer JH. Control of pancreatic exocrine secretion. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1981:821-9.
2. Forster ER, Green T, Elliot M, Bremner A, Dockray GJ. Gastric emptying in rats: role of afferent neurons and cholecystokinin. Am J Physiol 1990;258:G552-6.
3. Corwin RL, Smith GP. Different effects of CCK A antagonists on gastric-acid response to CCK and pentagastrin. Peptides 1993;14:253-7.
4. Silverman MA, Greenberg RE, Bank S. Cholecystokinin receptor antagonists: a review. Am J Gastroenterol 1987;82:703-7.
5. Lloyd KC, Raybould HE, Walsh IH. Cholecystokinin inhibits gastric acid secretion through type A cholecystokinin receptors and somatostatin in rats. Am J Physiol 1992;263:287-92.
6. Konturek SJ, Bilski J, Cieszkowski M. Role of cholecystokinin in the intestinal fat- and acid-induced inhibition of gastric secretion. Regul Pept 1992;42:97-109.
7. Lloyd KCK, Maxwell V, Kovacs TO, Miller J, Walsh IH. Cholecystokinin receptor antagonist MK329 blocks intestinal fat induced inhibition of meal stimulated gastric acid secretion. Gastroenterology 1992;102:131-8.
8. Stroff T, Lambrecht N, Peskar BM. Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin. Eur J Pharmacol 1994;260:R1-2.
9. Konturek SJ, Brzozowski T, Pytko-Polonczyk J, Drozdowicz D. Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats. Eur J Pharmacol 1995;273:57-62.
10. Brzozowski T, Konturek SJ, Sliwowski Z, Pytko-Polonczyk J, Szlachcic A, Drozdowicz D. Role of capsaicin-sensitive sensory nerves in gastroprotection against acid independent and acid-dependent ulcerogens. Digestion 1996;57:424-32.
11. Konturek SJ, Brzozowski T, Pytko-Polonczyk J, Drozdowicz D. Comparison of cholecystokinin, pentagastrin and duodenal oleate in gastroprotection in rats. Scand J Gastroenterol 1995; 30:620-30.
12. Brzozowski T, Konturek PC, Konturek SJ, Ernst H, Stachura J, Hahn EG. Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defense against subsequent exposure to various strong irritants in rats. Gut 1995:37:749-57.
13. Brzozowski T, Drozdowicz D, Majka J, Konturek SJ. Studies on gastroprotection induced by capsaicin and papaverine. J Physiol Pharmacol 1992;43:309-22.
14. Louie D, May D, Miller P, Owyang C. Cholecystokinin mediates feedback regulation of pancreatic secretion in rats. Am J Physiol 1986;77:2042-7.
15. Konturek SJ, Krzyzek E, Bilski J. The importance of gastric secretion in the feedback control of interdigestive and postprandial pancreatic secretion in rats. Regul Pept 1994;36:85-97.
16. Whittle BJR, Lopez-Belmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-11.
17. Lloyd KCK, Holzer HH, Zittel TT, Raybould HE. Duodenal lipid inhibits gastric acid secretion by vagal, capsaicin-sensitive afferent pathways in rats. Am J Physiol 1993;264: G659-63.
18. Holzer P, Livingston EH, Saria A, Guth PH. Sensory nerves mediate protective vasodilatation in the rat gastric mucosa. Am J Physiol 1991;260:G363-70.
19. Konturek SJ, Brzozowski T, Stachura J, Dembinski A, Majka J. Role of gastric blood flow, neutrophil infiltration and mucosal cell proliferation in gastric adaptation to aspirin in the rat. Gut 1994;35:1189-96.
20. Moran TH, Ameglio PJ, Schwartz GJ, McHugh PR. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 1992; 262:46-50.
21. Fung L, Pokol-Daniel S, Greenberg GR. Cholecystokinin type A receptors mediate intestinal-fat induced inhibition of acid secretion through somatostatin-14 in dogs. Endocrinology 1994;134:2376-82.
22. Mercer DW, Klemmol K, Cross IM, Smith GS, Cashman M, Miller TA. Cholecystokinin induced protection against gastric injury is independent of endogenous somatostatin. Am J Physiol 1996;27:692-700.
23. Sakamoto S, Swierczek JS, Ogden WD, Thompson JC. Cytoprotective effect of pentagastrin and epidermal growth factor on stress ulcer formation. Ann Surg 1985;201:290-5.
24. Konturek SJ, Brzozowski T, Drozdowicz D, Garlicki J, Beck G. Role of leukotrienes and platelet activating factor in acute gastric mucosal lesions in rats. Eur J Pharmacol 1989;164:285-92.
25. Karmak F, Eliakim R, Okan E, Rachmilewitz D. Somatostatin effectively prevents ethanol and NSAID induced gastric mucosal damage in rats. Dig Dis Sci 1994;39:617-25.
26. Pendley CE, Fitzpatrick LR, Ewing RW, Molino BF, Martin GE. The gastrin/cholecystokinin-B receptor antagonist L365.260 reduces basal acid secretion and prevents gastrointestinal damage induced by aspirin, ethanol and cysteamine in the rat. J Pharmacol Exp Ther 1993;265:1348-54.
27. Owyang C, Louie DS, Tatum D. Feedback regulation of pancreatic enzyme secretion: suppression of cholecystokinin release by trypsin. J Clin Invest 1986;77:2042-7.
28. Petersen F, Olsen O, Jepsen LV, Christiansen I. Fat and gastric acid secretion. Digestion 1992;52:43-6.
29. Shiratori K, Watanabe S, Takeuchi T. Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-inhibition of gastric acid secretion in rats. Dig Dis Sci 1992; 17:397-402.
30. Feinle C, D'Amato M, Read NW. Cholecystokinin A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid. Gastroenterology 1996;110: 1379-85.
31. Schwortz GJ, Berkow G, McHugh PR, Moran TH. Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying. Am J Physiol 1993; 264:630-7.
32. Heinemann A, Jocic M, Peskar BM, Holzer P. CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide. Am J Physiol 1996;270:253-8.
33. Brzozowski T, Konturek SJ, Drozdowicz D, Dembinski A, Stachura J. Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. Digestion 1995;56:463-71.
34. Evangelista S, Maggi CA. Protection induced by cholecystokinin-8 (CCK-8) in ethanol-induced gastric lesions is mediated via vagal capsaicin-sensitive fibers and CCK receptors. Br J Pharmacol 1991;102:119-22.