메뉴 건너뛰기




Volumn 93, Issue 12, 2008, Pages 1843-1851

Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells

Author keywords

Chronic lymphocytic leukemia; Fludarabine; hENT2; TIGAR

Indexed keywords

FLUDARABINE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE TRANSPORTER; PROTEIN P53;

EID: 57349184777     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.13186     Document Type: Article
Times cited : (20)

References (39)
  • 1
    • 34547855136 scopus 로고    scopus 로고
    • Cell proliferation and death: Forgotten features of chronic lymphocytic leukemia B cells
    • Chiorazzi N. Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells. Best Pract Res Clin Haematol 2007;20:399-413.
    • (2007) Best Pract Res Clin Haematol , vol.20 , pp. 399-413
    • Chiorazzi, N.1
  • 3
    • 34547967320 scopus 로고    scopus 로고
    • Fludarabine: A review of its use in non-Hodgkin's lymphoma
    • Anderson VR, Perry CM. Fludarabine: a review of its use in non-Hodgkin's lymphoma. Drugs 2007;67:1633-55.
    • (2007) Drugs , vol.67 , pp. 1633-1655
    • Anderson, V.R.1    Perry, C.M.2
  • 4
    • 0032830965 scopus 로고    scopus 로고
    • In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia
    • Bellosillo B, Villamor N, Colomer D, Pons G, Montserrat E, Gil J. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 1999;94:2836-43.
    • (1999) Blood , vol.94 , pp. 2836-2843
    • Bellosillo, B.1    Villamor, N.2    Colomer, D.3    Pons, G.4    Montserrat, E.5    Gil, J.6
  • 5
    • 0030322149 scopus 로고    scopus 로고
    • In vitro sensitivity of chronic lymphocytic leukemia B-cells to fludarabine, 2-chlorodeoxyadenosine and chlorambucil: Correlation with clinicohematological and immunophenotypic features
    • Morabito F, Stelitano C, Callea I, Filangeri M, Oliva B, Sculli G, et al. In vitro sensitivity of chronic lymphocytic leukemia B-cells to fludarabine, 2-chlorodeoxyadenosine and chlorambucil: correlation with clinicohematological and immunophenotypic features. Haematologica 1996;81:224-31.
    • (1996) Haematologica , vol.81 , pp. 224-231
    • Morabito, F.1    Stelitano, C.2    Callea, I.3    Filangeri, M.4    Oliva, B.5    Sculli, G.6
  • 6
    • 0032844150 scopus 로고    scopus 로고
    • The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia
    • Pettitt AR, Sherrington PD, Cawley JC. The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia. Br J Haematol 1999;106:1049-51.
    • (1999) Br J Haematol , vol.106 , pp. 1049-1051
    • Pettitt, A.R.1    Sherrington, P.D.2    Cawley, J.C.3
  • 7
    • 0013040873 scopus 로고    scopus 로고
    • Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562
    • Dumontet C, Fabianowska-Majewska K, Mantincic D, Callet BE, Tigaud I, Gandhi V, et al. Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562. Br J Haematol 1999;106: 78-85.
    • (1999) Br J Haematol , vol.106 , pp. 78-85
    • Dumontet, C.1    Fabianowska-Majewska, K.2    Mantincic, D.3    Callet, B.E.4    Tigaud, I.5    Gandhi, V.6
  • 8
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: Mechanisms of drug resistance and reversal strategies
    • Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001;15:875-90.
    • (2001) Leukemia , vol.15 , pp. 875-890
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 10
    • 1242340288 scopus 로고    scopus 로고
    • The concentrative nucleoside transporter family, SLC28
    • Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflugers Arch 2004;447:728-34.
    • (2004) Pflugers Arch , vol.447 , pp. 728-734
    • Gray, J.H.1    Owen, R.P.2    Giacomini, K.M.3
  • 13
    • 19944428546 scopus 로고    scopus 로고
    • Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): Identification of fludarabine-sensitive and -insensitive populations
    • Mackey JR, Galmarini CM, Graham KA, Joy AA, Delmer A, Dabbagh L, et al. Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations. Blood 2005;105:767-74.
    • (2005) Blood , vol.105 , pp. 767-774
    • Mackey, J.R.1    Galmarini, C.M.2    Graham, K.A.3    Joy, A.A.4    Delmer, A.5    Dabbagh, L.6
  • 14
    • 19944427083 scopus 로고    scopus 로고
    • Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells
    • Molina-Arcas M, Marce S, Villamor N, Huber-Ruano I, Casado FJ, Bellosillo B, et al. Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells. Leukemia 2005;19:64-8.
    • (2005) Leukemia , vol.19 , pp. 64-68
    • Molina-Arcas, M.1    Marce, S.2    Villamor, N.3    Huber-Ruano, I.4    Casado, F.J.5    Bellosillo, B.6
  • 15
    • 33751085679 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells
    • Molina-Arcas M, Moreno-Bueno G, Cano-Soldado P, Hernandez-Vargas H, Casado FJ, Palacios J, et al. Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells. Biochem Pharmacol 2006;72:1646-56.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1646-1656
    • Molina-Arcas, M.1    Moreno-Bueno, G.2    Cano-Soldado, P.3    Hernandez-Vargas, H.4    Casado, F.J.5    Palacios, J.6
  • 16
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764-75.
    • (2003) N Engl J Med , vol.348 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3    Bellosillo, B.4    Colomer, D.5    Rozman, M.6
  • 17
    • 0036721455 scopus 로고    scopus 로고
    • Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia
    • Bellosillo B, Villamor N, López-Guillermo A, Marcé S, Bosch F, Campo E, et al. Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood 2002;100:1810-6.
    • (2002) Blood , vol.100 , pp. 1810-1816
    • Bellosillo, B.1    Villamor, N.2    López-Guillermo, A.3    Marcé, S.4    Bosch, F.5    Campo, E.6
  • 18
    • 18744409028 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia
    • Bosch F, Ferrer A, Lopez-Guillermo A, Gine E, Bellosillo B, Villamor N, et al. Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia. Br J Haematol 2002;119:976-84.
    • (2002) Br J Haematol , vol.119 , pp. 976-984
    • Bosch, F.1    Ferrer, A.2    Lopez-Guillermo, A.3    Gine, E.4    Bellosillo, B.5    Villamor, N.6
  • 20
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2′-difluorodeoxycytidine-induced cytotoxicity
    • Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A, Pastor-Anglada M. Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2′-difluorodeoxycytidine-induced cytotoxicity. Clin Cancer Res 2003;9:5000-8.
    • (2003) Clin Cancer Res , vol.9 , pp. 5000-5008
    • Garcia-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3    Mazo, A.4    Pastor-Anglada, M.5
  • 21
    • 33745792969 scopus 로고    scopus 로고
    • Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma
    • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, et al. Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica 2006;91:895-902.
    • (2006) Haematologica , vol.91 , pp. 895-902
    • Marce, S.1    Molina-Arcas, M.2    Villamor, N.3    Casado, F.J.4    Campo, E.5    Pastor-Anglada, M.6
  • 23
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000;343:1750-7.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3    Kolitz, J.4    Elias, L.5    Shepherd, L.6
  • 24
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:957-67.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 25
    • 40749128044 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: High response rate and disease eradication
    • Bosch F, Ferrer A, Villamor N, Gonzalez M, Briones J, Gonzalez-Barca E, et al. Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication. Clin Cancer Res 2008;14:155-61.
    • (2008) Clin Cancer Res , vol.14 , pp. 155-161
    • Bosch, F.1    Ferrer, A.2    Villamor, N.3    Gonzalez, M.4    Briones, J.5    Gonzalez-Barca, E.6
  • 26
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic Bcell leukemias
    • Dohner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic Bcell leukemias. Blood 1995;85:1580-9.
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3    Hansen, K.4    Benner, A.5    Cabot, G.6
  • 27
    • 33947544426 scopus 로고    scopus 로고
    • Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: Results from the US Intergroup phase III trial E2997
    • Grever MR, Lucas DM, Dewald GW, Neuberg DS, Reed JC, Kitada S, et al. Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup phase III trial E2997. J Clin Oncol 2007;25:799-804.
    • (2007) J Clin Oncol , vol.25 , pp. 799-804
    • Grever, M.R.1    Lucas, D.M.2    Dewald, G.W.3    Neuberg, D.S.4    Reed, J.C.5    Kitada, S.6
  • 28
    • 0033028601 scopus 로고    scopus 로고
    • Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms
    • Pettitt AR, Clarke AR, Cawley JC, Griffiths SD. Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms. Br J Haematol 1999;105:986-8.
    • (1999) Br J Haematol , vol.105 , pp. 986-988
    • Pettitt, A.R.1    Clarke, A.R.2    Cawley, J.C.3    Griffiths, S.D.4
  • 29
    • 4444228658 scopus 로고    scopus 로고
    • Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response
    • Rosenwald A, Chuang EY, Davis RE, Wiestner A, Alizadeh AA, Arthur DC, et al. Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response. Blood 2004;104:1428-34.
    • (2004) Blood , vol.104 , pp. 1428-1434
    • Rosenwald, A.1    Chuang, E.Y.2    Davis, R.E.3    Wiestner, A.4    Alizadeh, A.A.5    Arthur, D.C.6
  • 30
    • 0345688175 scopus 로고    scopus 로고
    • Nucleoside anticancer drugs: The role of nucleoside transporters in resistance to cancer chemotherapy
    • Damaraju VL, Damaraju S, Young JD, Baldwin SA, MacKey J, Sawyer MB, et al. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 2003;22:7524-36.
    • (2003) Oncogene , vol.22 , pp. 7524-7536
    • Damaraju, V.L.1    Damaraju, S.2    Young, J.D.3    Baldwin, S.A.4    MacKey, J.5    Sawyer, M.B.6
  • 31
    • 34249899423 scopus 로고    scopus 로고
    • Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes
    • Smal C, Van Den NE, Maerevoet M, Poire X, Theate I, Bontemps F. Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes. Cancer Lett 2007;253:68-73.
    • (2007) Cancer Lett , vol.253 , pp. 68-73
    • Smal, C.V.D.N.1    Maerevoet, M.2    Poire, X.3    Theate, I.4    Bontemps, F.5
  • 32
    • 0036180689 scopus 로고    scopus 로고
    • Cytotoxicity of 2-chlorodeoxy-adenosine and arabinosylcytosine in leukaemic lymphoblasts from paediatric patients: Significance of cellular nucleoside transporter content
    • Wright AM, Paterson AR, Sowa B, Akabutu JJ, Grundy PE, Gati WP. Cytotoxicity of 2-chlorodeoxy-adenosine and arabinosylcytosine in leukaemic lymphoblasts from paediatric patients: significance of cellular nucleoside transporter content. Br J Haematol 2002;116:528-37.
    • (2002) Br J Haematol , vol.116 , pp. 528-537
    • Wright, A.M.1    Paterson, A.R.2    Sowa, B.3    Akabutu, J.J.4    Grundy, P.E.5    Gati, W.P.6
  • 33
    • 0030971066 scopus 로고    scopus 로고
    • Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein
    • Gati WP, Paterson AR, Larratt LM, Turner AR, Belch AR. Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein. Blood 1997;90:346-53.
    • (1997) Blood , vol.90 , pp. 346-353
    • Gati, W.P.1    Paterson, A.R.2    Larratt, L.M.3    Turner, A.R.4    Belch, A.R.5
  • 34
    • 0037441744 scopus 로고    scopus 로고
    • Differential mRNA expression of ara-C-metabolizing enzymes explains ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia
    • Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, et al. Differential mRNA expression of ara-C-metabolizing enzymes explains ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 2003;101:1270-6.
    • (2003) Blood , vol.101 , pp. 1270-1276
    • Stam, R.W.1    den Boer, M.L.2    Meijerink, J.P.3    Ebus, M.E.4    Peters, G.J.5    Noordhuis, P.6
  • 35
    • 28644447388 scopus 로고    scopus 로고
    • The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia
    • Hubeek I, Stam RW, Peters GJ, Broekhuizen R, Meijerink JP, van Wering ER, et al. The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia. Br J Cancer 2005;93:1388-94.
    • (2005) Br J Cancer , vol.93 , pp. 1388-1394
    • Hubeek, I.1    Stam, R.W.2    Peters, G.J.3    Broekhuizen, R.4    Meijerink, J.P.5    van Wering, E.R.6
  • 37
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004;10:6956-61.
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3    Dabbagh, L.4    Young, J.D.5    Dumontet, C.6
  • 38
    • 0037165658 scopus 로고    scopus 로고
    • PKC regulation of the human equilibrative nucleoside transporter, hENT1
    • Coe I, Zhang Y, McKenzie T, Naydenova Z. PKC regulation of the human equilibrative nucleoside transporter, hENT1. FEBS Lett 2002;517:201-5.
    • (2002) FEBS Lett , vol.517 , pp. 201-205
    • Coe, I.1    Zhang, Y.2    McKenzie, T.3    Naydenova, Z.4
  • 39
    • 8644236778 scopus 로고    scopus 로고
    • Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
    • Farre X, Guillen-Gomez E, Sanchez L, Hardisson D, Plaza Y, Lloberas J, et al. Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Int J Cancer 2004;112:959-66.
    • (2004) Int J Cancer , vol.112 , pp. 959-966
    • Farre, X.1    Guillen-Gomez, E.2    Sanchez, L.3    Hardisson, D.4    Plaza, Y.5    Lloberas, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.