Lycopene biodistribution is altered in 15,15′-carotenoid monooxygenase knockout mice1-3

Journal of Nutrition

Volumn 138, Issue 12, 2008, Pages 2367-2371

  Lindshield, Brian L ^a   King, Jennifer L ^a   Wyss, Adrian ^b   Goralczyk, Regina ^b   Lu, Chi Hua ^a   Ford, Nikki A ^a   Erdman Jr , John W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

15,15' CAROTENOID MONOOXYGENASE; BETA CAROTENE; CAROTENOID; CHOLESTEROL; LYCOPENE; RETINOL; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN FUNCTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PROSTATE; SEMINAL VESICLE; SPLEEN FUNCTION; TESTIS FUNCTION; THYMUS FUNCTION; UTERUS WEIGHT;

ANIMALS; BETA CAROTENE; BETA-CAROTENE 15,15'-MONOOXYGENASE; CAROTENOIDS; CHOLESTEROL; DIET; FEMALE; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RETINOIDS; TISSUE DISTRIBUTION;

MUS;

EID: 57349182281     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.099663     Document Type: Article

References (35)

1. Lindshield BL, Erdman JW. Carotenoids. In: Bowman BA, Russell RM, editors. Present knowledge in nutrition. 9th ed. Washington, DC: International Life Sciences Institute; 2006. p. 184-97.
2. Moore T. Vitamin A and carotene: the association of vitamin A activity with carotene in the carrot root. Biochem J. 1929;23:803-11.
3. Olson JA, Hayaishi O. The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine. Proc Natl Acad Sci USA. 1965;54:1364-70.
4. Goodman DS, Huang HS. Biosynthesis of vitamin A with rat intestinal enzymes. Science. 1965;149:879-80.
5. Paik J, During A, Harrison EH, Mendelsohn CL, Lai K, Blaner WS. Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids. J Biol Chem. 2001;276:32160-8.
6. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, et al. Cloning and characterization of a human beta, beta-carotene-15,15′-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001;72:193-202.
7. Wyss A, Wirtz G, Woggon W, Brugger R, Wyss M, Friedlein A, Bachmann H, Hunziker W. Cloning and expression of beta, beta-carotene 15,15′- dioxygenase. Biochem Biophys Res Commun. 2000;271:334-6.
8. Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001;276:14110-6.
9. Redmond TM, Gentleman S, Duncan T, Yu S, Wiggert B, Gantt E, Cunningham FX Jr. Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15′-dioxygenase. J Biol Chem. 2001;276:6560-5.
10. Lindqvist A, Andersson S. Biochemical properties of purified recombinant human beta-carotene 15,15′-monooxygenase. J Biol Chem. 2002;277:23942-8.
11. Zaripheh S, Nara TY, Nakamura MT, Erdman JW Jr. Dietary lycopene downregulates carotenoid 15,15′-monooxygenase and PPAR-gamma in selected rat tissues. J Nutr. 2006;136:932-8.
12. Wang XD, Krinsky NI, Tang GW, Russell RM. Retinoic acid can be produced from excentric cleavage of beta-carotene in human intestinal mucosa. Arch Biochem Biophys. 1992;293:298-304.
13. Wang XD, Russell RM, Liu C, Stickel F, Smith DE, Krinsky NI. Beta-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from beta-apocarotenoic acids. J Biol Chem. 1996;271:26490-8.
14. Liu C, Wang XD, Russell RM. Biosynthesis of retinoic acid from β-apo-14′-carotenal in ferret in vivo. J Nutr Biochem. 1997;8:652-7.
15. Hessel S, Eichinger A, Isken A, Amengual J, Hunzelmann S, Hoeller U, Elste V, Hunziker W, Goralczyk R, et al. CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J Biol Chem. 2007;282:33553-61.
16. Fierce Y, de Morais Vieira M, Piantedosi R, Wyss A, Blaner WS, Paik J. In vitro and in vivo characterization of retinoid synthesis from beta-carotene. Arch Biochem Biophys. 2008;472:126-38.
17. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
18. Kirk EA, Sutherland P, Wang SA, Chait A, LeBoeuf RC. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr. 1998;128:954-9.
19. Zaripheh S, Boileau TW, Lila MA, Erdman JW Jr. [14C]-lycopene and [14C]-labeled polar products are differentially distributed in tissues of F344 rats prefed lycopene. J Nutr. 2003;133:4189-95.
20. Deming DM, Teixeira SR, Erdman JW Jr. All-trans beta-carotene appears to be more bioavailable than 9-cis or 13-cis beta-carotene in gerbils given single oral doses of each isomer. J Nutr. 2002;132:2700-8.
21. Boileau TW, Clinton SK, Erdman JW Jr. Tissue lycopene concentrations and isomer patterns are affected by androgen status and dietary lycopene concentration in male F344 rats. J Nutr. 2000;130:1613-8.
22. Yeum KJ, Booth SL, Sadowski JA, Liu C, Tang G, Krinsky NI, Russell RM. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Am J Clin Nutr. 1996;64:594-602.
23. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497-509.
24. Cohen J, Cohen P. Applied multiple regression/correlation analysis for the behavioral sciences. 2nd ed. Hillsdale: Lawrence Erlbaum Associates, Publishers; 1983.
25. Weigel RM, Narvaez M. Multiple regression analysis of differential response to treatment in randomized controlled clinical trials. Control Clin Trials. 1991;12:378-94.
26. Narayanan A, Watts D. Exact methods in the NPAR1WAY procedure. Cary (NC): SAS Institute Inc.; 1996.
27. Lindshield BL, Canene-Adams K, Erdman JW Jr. Lycopenoids: are lycopene metabolites bioactive? Arch Biochem Biophys. 2007;458:136-40.
28. Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD. The biochemical characterization of ferret carotene-9′,10′-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. J Biol Chem. 2006;281:19327-38.
29. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr. cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev. 1996;5:823-33.
30. Boileau AC, Merchen NR, Wasson K, Atkinson CA, Erdman JW Jr. Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. J Nutr. 1999;129:1176-81.
31. Failla ML, Chitchumroonchokchai C, Ishida BK. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J Nutr. 2008;138:482-6.
32. Vogel JT, Tan BC, McCarty DR, Klee HJ. The carotenoid cleavage dioxygenase 1 enzyme has broad substrate specificity, cleaving multiple carotenoids at two different bond positions. J Biol Chem. 2008;283:11364-73.
33. During A, Dawson HD, Harrison EH. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005;135:2305-12.
34. Moussa M, Landrier JF, Reboul E, Ghiringhelli O, Comera C, Collet X, Frohlich K, Bohm V, Borel P. Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not niemann-pick C1-like 1. J Nutr. 2008;138:1432-6.
35. Lindqvist A, Sharvill J, Sharvill DE, Andersson S. Loss-of-function mutation in carotenoid 15,15′-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A. J Nutr. 2007;137:2346-50.