Biosynthesis of retinoic acid from β-apo-14'-carotenal in ferret in vivo

Journal of Nutritional Biochemistry

Volumn 8, Issue 11, 1997, Pages 652-657

  Liu, Chun ^a   Wang, Xiang Dong ^a   Russell, Robert M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

apo carotenal; apo carotenoic acid; carotene; Ferret; Retinoic acid; Retinol

Indexed keywords

CAROTENOID; RETINAL; RETINOIC ACID; RETINOL;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; FERRET; INTESTINE MUCOSA; MALE; NONHUMAN;

EID: 0030733149     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(97)00122-8     Document Type: Article

References (20)

1. Olson, J.A. (1996). Vitamin A. In Present Knowledge in Nutrition (E.E. Ziegler and L.J. Filer, Jr., ed.), pp. 109-119. ILSI Press., Washington, DC USA
2. Pfahl, M. and Chytil F. (1996). Regualtion of metabolism by retinoic acid and its nuclear receptor. Anna. Rev. Nutr. 16, 257-283
3. Napoli, J.L. and Race, K.R. (1988). Biogenesis of retinoic acid from β-carotene. Differences between the metabolism of β-carotene and retinal. J. Biol. Chem. 263, 17372-17377
4. Wang, X-D., Krinsky, N.I., Tang, G., and Russell R.M. (1992). Retinoic acid can be produced from excentric cleavage of β-carotene in human intestinal mucosa. Arch. Biochem. Biophys. 293, 293-304
5. Wang, X-D., Russell, R.M., Liu, C., Stickel, F., Smith, D.E.H., and Krinsky, N.I. (1996). β-Oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from β-apo-carotenoic acid. J. Biol. Chem. 271, 26490-26498
6. Hebuterne, X., Wang, X.-D., Smith, D., Tang, G., and Russell, R.M. (1996). In vivo biosynthesis of retinoic acid from β-carotene involves an excentric cleavage pathway in ferret intestine. J. Lipid Res. 37, 482-492
7. Nagao, A. and Olson, J.A. (1994). Enzymatic formation of 9-cis, 13-cis, and all-trans-retinals from isomers of β-carotene. FASEB J. 8, 968-973
8. Wang, X-D., Krinsky, N.I., Benotti, P.N., and Russell, R.M. (1994). Biosynthesis of 9-cis-retinoic acid from 9-cis-β-carotene in human intestinal mucosa. Arch. Biochem. Biophys. 313, 150-155
9. Hebuterne, X., Wang, X-D., Johnson, E.J., Krinsky, N.I., and Russell, R.M. (1995). Intestinal absorption and metabolism of 9-cis-β-carotene in vivo: Biosythesis of 9-cis-retinoic acid. J. Lipid Res. 36, 1264-1273
10. Glover, J. (1960). Conversion of β-carotene into vitamin A in the intestine of the rat. Vitam. Horm. 18, 371-386
11. Goodman, D.S. and Olson, J.A. (1969). The conversion of all-trans-β-carotene into retinol. Methods Enzymol. 15, 510-535
12. Ganguly, J. and Sastry, P.S. (1985). Mechanism of conversion of β-carotene into vitamin A-central cleavage versus random cleavage. Wld. Rev. Nutr. Diet. 45, 198-220
13. Devery, J. and Milborrow, B.V. (1994). β-Carotene-15,15'-dioxygenase (EC 1.13.11.21): Isolation, reaction mechanism and an improved assay procedure. Brit. J. Nutr. 72, 397-414
14. Crain, F.D., Lotspeich, F.J., and Krause, R.F. (1967). Biosynthesis of retinoic acid by intestinal enzymes of the rat. J. Lipid Res. 8. 249-254
15. Sharma, R.V., Mathur, S.N., and Ganguly, J. (1976). Studies on the relative biopotencies and intestinal absorption of different apo-β-carotenoids in rats and chickens. Biochem. J. 158, 377-383
16. Sharma, R.V., Mathur, S.N., Dimitrovskii, A.A., Das, R.C., and Ganguly, J. (1977). Studies on the metabolism of β-carotene and apo-β-carotenoids in rats and chickens. Biochim. Biophys. Acta. 486, 183-194
17. Wang, X-D., Krinsky, N.I., Marini, R., Tang, G., Yu, J., Fox, J., and Russell, R.M. (1992). Intestinal uptake and lymphatic absorption of β-carotene in ferrets: a model for human β-carotene metabolism. Am. J. Physiol. 263, G480-G486
18. Wang, X.-D., Krinsky, N.I., and Russell, R.M. (1993). Retinoic acid regulates retinol metabolism via feedback inhibition of retinol oxidation and stimulation of retinyl esterification in ferret liver. J. Nutr. 123, 1277-1285
19. Wang, X-D., Tang, G., Fox, J.G., Krinsky, N.I., and Russell, R.M. (1991). Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues. Arch. Biochem. Biophys. 285, 8-16
20. Zeng, S., Furr, H.C., and Olson, J.A. (1992). Metabolism of carotenoid analogs in humans. Am. J. Clin. Nutr. 56, 433-439