Safety evaluation of Bt plants

Japan Agricultural Research Quarterly

Volumn 42, Issue 4, 2008, Pages 251-259

  Shimada, Nobuaki ^a   Murata, Hideo ^a   Miyazaki, Shigeru ^a  

^a NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Cattle; Genetically modified plant; Pig; Poultry

Indexed keywords

ANIMALIA; BACILLUS THURINGIENSIS; BACTERIA (MICROORGANISMS); BOS; HEXAPODA; SUIDAE; ZEA MAYS;

EID: 57349175988     PISSN: 00213551     EISSN: None     Source Type: Journal    
DOI: 10.6090/jarq.42.251     Document Type: Review

References (63)

1. Aeschbacher, K. et al. (2005) Bt176 corn in poultry nutrition: physiological characteristics and fate of recombinant plant DNA in chickens. Poult. Sci., 84, 385-394.
2. Aulrich, K. et al. (2001) Genetically modified feeds in animal nutrition. 1st communication: Bacillus thuringiensis (Bt) corn in poultry, pig and ruminant nutrition. Arch. Tierernähr., 54, 183-195.
3. Barriere, Y. et al. (2001) Feeding value of corn silage estimated with sheep and dairy cows is not altered by genetic incorporation of Bt1376 resistance to Ostrinia nubilalis. J. Dairy Sci., 84, 1863-1871.
4. Betz, F. S., Hammond, B. G. & Fuchs, R. L. (2000) Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul. Toxicol. Pharmacol., 32, 156-173.
5. Brake, D. G., Thaler, R. & Evenson, D. P. (2004) Evaluation of Bt (Bacillus thuringiensis) corn on mouse testicular development by dual parameter flow cytometry. J. Agric. Food Chem., 52, 2097-2102.
6. Brake, J. & Vlachos, D. (1998) Evaluation of transgenic event 176 "Bt" corn in broiler chickens. Poult. Sci., 77, 648-653.
7. Brake, J., Faust, M. A. & Stein, J. (2003) Evaluation of transgenic event Bt11 hybrid corn in broiler chickens. Poult. Sci., 82, 551-559.
8. Castillo, A. R. et al. (2004) Effects of feeding rations with genetically modified whole cottonseed to lactating Holstein cows. J. Dairy Sci., 87, 1778-1785.
9. Chowdhury, E. H. et al. (2003) Detection of genetically modified maize DNA fragments in the intestinal contents of pigs fed StarLink CBH351. Vet. Hum. Toxicol., 45, 95-96.
10. Chowdhury, E. H. et al. (2003) Detection of corn intrinsic and recombinant DNA fragments and Cry1Ab protein in the gastrointestinal contents of pigs fed genetically modified corn Bt11. J. Anim. Sci., 81, 2546-2551.
11. Chowdhury, E. H. et al. (2003) Detection of Cry1Ab protein in gastrointestinal contents but not visceral organs of genetically modified Bt11-fed calves. Vet. Hum. Toxicol., 45, 72-75.
12. Chowdhury, E. H. et al. (2004) Fate of maize intrinsic and recombinant genes in calves fed genetically modified maize Bt11. J. Food Prot., 67, 365-370.
13. Cohen, S. N. et al. (1973) Construction of biologically functional bacterial plasmids in vitro. Proc. Natl. Acad. Sci. USA, 70, 3240-3244.
14. Crickmore, N. et al. (1998) Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins. Microbiol. Mol. Biol. Rev., 62, 807-813.
15. Crickmore, N. et al. (2007) Bacillus thuringiensis toxin nomenclature. http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/.
16. de Maagd, R. A., Bravo, A. & Crickmore, N. (2001) How Bacillus thuringiensis has evolved specific toxins to colonize the insect world. Trends Genet., 17, 193-199.
17. Deaville, E. R. & Maddison, B. C. (2005) Detection of transgenic and endogenous plant DNA fragments in the blood, tissues, and digesta of broilers. J. Agric. Food Chem., 53, 10268-10275.
18. Donkin, S. S. et al. (2003) Effects of feeding silage and grain from glyphosate-tolerant or insect-protected corn hybrids on feed intake, ruminal digestion, and milk production in dairy cattle. J. Dairy Sci., 86, 1780-1788.
19. Duggan, P. S. et al. (2003) Fate of genetically modified maize DNA in the oral cavity and rumen of sheep. Br. J. Nutr., 89, 159-166.
20. EPA (2001) Biopesticides registration action document - Bacillus thuringiensis plant-incorporated protectants. http://www.epa.gov/oppbppd1/ biopesticides/pips/bt_brad.htm.
21. Flachowsky, G., Halle, I. & Aulrich, K. (2005) Long term feeding of Bt-corn-a ten-generation study with quails. Arch. Anim. Nutr., 59, 449-451.
22. Folmer, J. D. et al. (2002) Utilization of Bt corn residues by grazing beef steers and Bt corn silage and grain by growing beef cattle and lactating dairy cows. J. Anim. Sci., 80, 1352-1361.
23. Grant, R. J. et al. (2003) Influence of glyphosate-tolerant (event nk603) and corn rootworm protected (event MON863) corn silage and grain on feed consumption and milk production in Holstein cattle. J. Dairy Sci., 86, 1707-1715.
24. Griffitts, J. S. & Aroian, R. V. (2005) Many roads to resistance: how invertebrates adapt to Bt toxins. Bioessays, 27, 614-624.
25. Hamilton, K. A. et al. (2004) Bollgard II cotton: compositional analysis and feeding studies of cottonseed from insect-protected cotton (Gossypium hirsutum L.) producing the Cry1Ac and Cry2Ab2 proteins. J. Agric. Food Chem., 52, 6969-6976.
26. Hammond, B. et al. (2006) Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn. Food Chem. Toxicol., 44, 147-160.
27. Hofmann, C. et al. (1988) Binding of the delta endotoxin from Bacillus thuringiensis to brush-border membrane vesicles of the cabbage butterfly (Pieris brassicae). Eur. J. Biochem., 173, 85-91.
28. ISAAA (2007) Global status of commercialized biotech/GM crops: 2006. http://www.isaaa.org/Resources/Publications/briefs/35/executivesummary/default. html.
29. Jennings, J. C. et al. (2003) Attempts to detect transgenic and endogenous plant DNA and transgenic protein in muscle from broilers fed YieldGard Corn Borer Corn. Poult. Sci., 82, 371-380.
30. Jung, Y. C. et al. (2007) Isolation and characterization of a novel Bacillus thuringiensis strain expressing a novel crystal protein with cytocidal activity against human cancer cells. J. Appl. Microbiol., 103, 65-79.
31. Linn, S. & Arber, W. (1968) Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form. Proc. Natl. Acad. Sci. USA, 59, 1300-1306.
32. MacKenzie, S. A. et al. (2007) Thirteen week feeding study with transgenic maize grain containing event DAS-O15O7-1 in Sprague-Dawley rats. Food Chem. Toxicol., 45, 551-562.
33. Malley, L. A. et al. (2007) Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats. Food. Chem. Toxicol., 45, 1277-1292.
34. Mazza, R. et al. (2005) Assessing the transfer of genetically modified DNA from feed to animal tissues. Transgenic Res., 14, 775-784.
35. McClintock, J. T., Schaffer, C. R. & Sjoblad, R. D. (1995) A comparative review of the mammalian toxicity of Bacillus thuringiensis-based pesticides. Pestic. Sci., 45, 95-105.
36. Nishitsutsuji-uwo, J., Endo, Y. & Himeno, M. (1980) Effects of Bacillus thuringiensis δ-endotoxin on insect and mammalian cells in vitro. Appl. Entomol. Zool., 15, 133-139.
37. Okumura, S. et al. (2005) Identification of a novel cytotoxic protein, Cry45Aa, from Bacillus thuringiensis A1470 and its selective cytotoxic activity against various mammalian cell lines. J. Agric. Food Chem., 53, 6313-6318.
38. Okunuki, H. et al. (2002) Increased digestibility of two products in genetically modified food (CP4-EPSPS and Cry1Ab) after preheating. Shokuhin eiseigaku zasshi (J. Food Hyg. Soc. Jpn.), 43, 68-73.
39. Reuter, T. et al. (2002) Investigations on genetically modified maize (Bt-maize) in pig nutrition: chemical composition and nutritional evaluation. Arch. Tierernähr., 56, 23-31.
40. Rossi, F. et al. (2005) Effect of Bt corn on broiler growth performance and fate of feed-derived DNA in the digestive tract. Poult. Sci., 84, 1022-1030.
41. +-gradient-dependent amino acid transport across the brush border membrane of Pieris brassicae midgut cells. FEBS Lett., 204, 213-218.
42. Schnepf, E. et al. (1998) Bacillus thuringiensis and its pesticidal crystal proteins. Microbiol. Mol. Biol. Rev., 62, 775-806.
43. Schrøder, M. et al. (2007) A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem. Toxicol., 45, 339-349.
44. Shimada, N. et al. (2003) Effects of Bacillus thuringiensis Cry1Ab toxin on mammalian cells. J. Vet. Med. Sci., 65, 187-191.
45. Shimada, N. et al. (2006) Bacillus thuringiensis insecticidal Cry1Ab toxin does not affect the membrane integrity of the mammalian intestinal epithelial cells: An in vitro study. In Vitro Cell. Dev. Biol. Anim., 42, 45-49.
46. Shimada, N. et al. (2006) Binding of Cry1Ab toxin, a Bacillus thuringiensis insecticidal toxin, to proteins of the bovine intestinal epithelial cell: An in vitro study. Appl. Entomol. Zool., 41, 295-301.
47. Shimada, N. et al. (2006) Effects of feeding calves genetically modified corn bt11: a clinico-biochemical study. J. Vet. Med. Sci., 68, 1113-1115.
48. Taylor, M. L. et al. (2003) Comparison of broiler performance when fed diets containing grain from roundup ready (NK603), yieldgard x roundup ready (MON810 x NK603), non-transgenic control, or commercial corn. Poult. Sci., 82, 443-453.
49. Taylor, M. L. et al. (2003) Comparison of broiler performance when fed diets containing grain from YieldGard (MON810), YieldGard x Roundup Ready (GA21), non-transgenic control, or commercial corn. Poult. Sci., 82, 823-830.
50. Taylor, M. L. et al. (2003) Comparison of broiler performance when fed diets containing grain from YieldGard Rootworm (MON863), YieldGard Plus (MON810 x MON863), nontransgenic control, or commercial reference corn hybrids. Poult. Sci., 82, 1948-1956.
51. Taylor, M. L. et al. (2005) Comparison of broiler performance when fed diets containing corn grain with insect-protected (corn rootworm and European corn borer) and herbicide-tolerant (glyphosate) traits, control corn, or commercial reference corn - revisited. Poult. Sci., 84, 1893-1899.
52. Taylor, M. et al. (2007) Comparison of broiler performance when fed diets containing grain from second-generation insect-protected and glyphosate-tolerant, conventional control or commercial reference corn. Poult. Sci., 86, 1972-1979.
53. Taylor, M. et al. (2007) Comparison of broiler performance and carcass parameters when fed diets containing combined trait insect-protected and glyphosate-tolerant corn (MON 89034 x NK603), control, or conventional reference corn. Poult. Sci., 86, 1988-1994.
54. Teshima, R. et al. (2002) Effect of subchronic feeding of genetically modified corn (CBH351) on immune system in BN rats and B10A mice. Shokuhin eiseigaku zasshi (J. Food Hyg. Soc. Jpn), 43, 273-279.
55. Tony, M. A. et al. (2003) Safety assessment of Bt 176 maize in broiler nutrition: degradation of maize-DNA and its metabolic fate. Arch. Tierernähr., 57, 235-252.
56. Tsuda, Y. et al. (2003) Cytotoxic activity of Bacillus thuringiensis Cry proteins on mammalian cells transfected with cadherin-like Cry receptor gene of Bombyx mori (silkworm). Biochem. J., 369, 697-703.
57. Vaeck, M. et al. (1987) Transgenic plants protected from insect attack. Nature, 328, 33-37.
58. Vander Pol, K. J. et al. (2005) Effects of grazing residues or feeding corn from a corn rootworm-protected hybrid (MON 863) compared with reference hybrids on animal performance and carcass characteristics. J. Anim. Sci., 83, 2826-2834.
59. Watson, J. D. & Crick, F. H. (1953) Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature, 171, 737-738.
60. Wiedemann, S. et al. (2006) In situ studies on the time-dependent degradation of recombinant corn DNA and protein in the bovine rumen. J. Anim. Sci., 84, 135-144.
61. Yamashita, S. et al. (2005) Typical three-domain cry proteins of Bacillus thuringiensis strain A1462 exhibit cytocidal activity on limited human cancer cells. J. Biochem., 138, 663-672.
62. Yamazaki, M., Murakami, H. & Saitoh, M. (2003) Effect of feeding Bt corn on growth performance and nutritive value in pig and poultry. Bull. Natl. Inst. Livest. Grassl. Sci., 4, 15-21 [In Japanese with English summary].
63. Zimmerman, S. B. et al. (1967) Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide. Proc. Natl. Acad. Sci. USA, 57, 1841-1848.