Differential effects of retinol and retinoic acid on cell proliferation: A role for reactive species and redox-dependent mechanisms in retinol supplementation

Free Radical Research

Volumn 42, Issue 9, 2008, Pages 778-788

  Zanotto Filho, Alfeu ^a   Schroder, Rafael ^a   Moreira, Jose Claudio ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

MAPKs; Proliferation; Reactive species; Retinoic acid; Retinol

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; REACTIVE OXYGEN METABOLITE; RETINOIC ACID; RETINOL; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UO 126; XANTHINE OXIDASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; MITOCHONDRION; NONHUMAN; RAT; SERTOLI CELL;

ANIMALS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; OXIDANTS; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REACTIVE OXYGEN SPECIES; SERTOLI CELLS; VITAMIN A; XANTHINE OXIDASE;

EID: 57349166762     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802385702     Document Type: Article

References (50)

1. Blomhoff, R. (1994) Vitamin A in health and disease, Marcel Dekker, New York
2. Kuratomi, Y., Kumamoto, Y., Yamashita, H., Yamamoto, T., Inokuchi, A. and Tomita, K. (1999) Comparison of survival rates of patients with nasopharyngeal carcinoma treated with radiotherapy, 5-fluorouracil and vitamin A ('FAR' therapy) vs FAR therapy plus adjunctive cisplatin and peplomycin chemotherapy. Eur Arch Otorhinolaryngol, 256, pp. S60-S63.
3. Okuno, M., Kojima, S., Matsushima-Nishiwaki, R., Tsurumi, Y., Muto, H., Friedman, SL and Moriwaki, H. (2004) Retinoids in cancer chemoprevention. Curr Cancer Drug Targets, 4, pp. 285-298.
4. Dragnev, KH, Petty, WJ and Dmitrovsky, E. (2003) Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther, 2, pp. S150-S156.
5. Omenn, GS. (2007) Chemoprevention of lung cancers: Lessons from CARET, the beta-carotene and retinol efficiency trial, and prospects for the future. Eur J Cancer Prev, 16, pp. 184-191.
6. Omenn, GS, Goodman, GE, Thornquist, MD, Lund, B., Metch, B. and Gylys-Colwell, I. (1994) The beta-carotene and retinol efficacy trial (CARET) for chemoprevention of lung cancer in high risk populations: smokers and asbestos-exposed workers. Cancer Res, 54, pp. 2038s-2043s.
7. Penniston, KL and Tanumihardjo, SA. (2006) The acute and chronic toxic effects of vitamin A. Am J Clin Nutr, 83, pp. 191-201.
8. Gelain, DP, Moreira, JC, Bevilaqua, LR, Dickson, PW and Dunkley, PR. (2007) Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells. J Neurochem, 103, pp. 2369-2379.
9. Gelain, DP and Moreira, JCF. (2008) Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells. Toxicol in Vitro, 22, pp. 553-558.
10. Gimeno, A., Zaragoza, R., Vivo-Sese, I., Vina, JR and Miralles, VJ. (2004) Retinol, at concentrations greater than the physiological limit, induces oxidative stress and apoptosis in human dermal fibroblasts. Exp Dermatol, 13, pp. 45-54.
11. Dal-Pizzol, F., Klamt, F., Dalmolin, RJ, Bernard, EA and Moreira, JC. (2001) Mitogenic signaling mediated by oxidants in retinol treated Sertoli cells. Free Radic Res, 35, pp. 749-755.
12. Klamt, F., Dal-Pizzol, F., Rohers, R., Oliveira, RB, Dalmolin, RJS, Henriques, JAP, Andrades, HHR, Ramos, ALLP and Moreira, JCF. (2003) Genotoxicity, recombinogenicity and preneoplasic transformation induced by Vitamin A supplementation. Mutat Res, 539, pp. 117-125.
13. Gelain, DP, Cammarota, M., Zanotto-Filho, A., de Oliveira, RB, Dal-Pizzol, F., Izquierdo, I., Bevilaqua, LR and Moreira, JC. (2006) Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells. Cell Signal, 18, pp. 1685-1694.
14. Zanotto-Filho, A., Schroder, R. and Moreira, JC. (2008) Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells. Free Radic Res, 42, pp. 593-601.
15. Klamt, F., Dal-Pizzol, F., Bernard, EA and Moreira, JC. (2003) Enhanced UV-mediated free radical generation. DNA and mitochondrial damage caused by retinol supplementation. Photochem Photobiol, 2, pp. 856-860.
16. Dal-Pizzol, F., Klamt, F., Benfato, MS, Bernard, EA and Moreira, JC. (2001) Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells. Free Radic Res, 34, pp. 395-404.
17. Dal-Pizzol, F., Klamt, F., Frota, ML, Moraes, LF, Moreira, JC and Benfato, MS. (2000) Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells. Free Radic Res, 33, pp. 677-687.
18. De Oliveira, MR, Silvestrin, RB, Mello e Souza, T and Moreira, JCF. (2008) Therapeutic vitamin a doses increase the levels of markers of oxidative insult in substantia nigra and decrease locomotory and exploratory activity in rats after acute and chronic supplementation. Neurochem Res, 33, pp. 378-383.
19. De Oliveira, MR and Moreira, JCF. (2007) Acute and chronic vitamin A supplementation at therapeutic doses induces oxidative stress in submitochondrial particles isolated from cerebral cortex and cerebellum of adult rats. Toxicol Lett, 173, pp. 145-150.
20. De Oliveira, MR, de Bittencourt Pasquali, MA, Silvestrin, RB, Mello e Souza, T and Moreira, JC. (2007) Vitamin A supplementation induces a prooxidative state in the striatum and impairs locomotory and exploratory activity of adult rats. Brain Res, 1169, pp. 112-119.
21. Klamt, F., Roberto de Oliveira, M and Moreira, JC. (2005) Retinol induces permeability transition and cytochrome c release from rat liver mitochondria. Biochim Biophys Acta, 1726, pp. 14-20.
22. Njar, VC, Gediya, L., Purushottamachar, P., Chopra, P., Vasaitis, TS, Khandelwal, A., Mehta, J., Huynh, C., Belosay, A. and Patel, J. (2006) Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg Med Chem, 14, pp. 4323-4340.
23. Greenwald, P., Anderson, N., Nelson, SA and Taylor, PR. (2006) Clinical trials of vitamin and mineral supplements for cancer chemoprevention. Am J Clin Nutr, 85, pp. 314S-317S.
24. Ono, K. and Yamada, M. (2007) Vitamin A potently destabilizes preformed alphasynuclein fibrils in vitro: Implications for Lewy body diseases. Neurobiol Dis, 25, pp. 446-454.
25. Kefaloyianni, E., Gaitanaki, C. and Beis, I. (2006) ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts. Cell Signal, 18, pp. 2238-2251.
26. Vernet, N., Dennefeld, C., Rochette-Egly, C., Oulad-Abdelghani, M., Chambon, P., Ghyselinck, NB and Mark, M. (2006) Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. Endocrinology, 147, pp. 96-110.
27. Livera, G., Rouiller-Fabre, V., Pairault, C., Levacher, C. and Habert, R. (2002) Regulation and perturbation of testicular functions by vitamin A. Reproduction, 124, pp. 173-180.
28. Jegou, B. and Sharpe, RM. (1999) Paracrine mechanisms in testicular control. Molecular biology of the male reproductive system, pp. 271-310. Academic Press, San Diego
29. Holsberger, DR, Buchold, GM, Leal, MC, Kiesewetter, SE, O'Brien, DA, Hess, RA, Franca, LR, Kiyokawa, H. and Cooke, PS. (2005) Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation. Biol Reprod, 72, pp. 1429-1436.
30. Lucas, TF, Siu, ER, Esteves, CA, Monteiro, HP, Oliveira, CA, Porto, CS and Lazari, MF. (2008) 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat sertoli cells. Biol Reprod, 78, pp. 101-104.
31. Henley, D., Isbill, M., Fernando, R., Foster, JS and Wimalasena, J. (2007) Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity. Cancer Chemother Pharmacol, 59, pp. 235-249.
32. Wang, H. and Joseph, JA. (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med, 27, pp. 612-616.
33. Boveris, A. (1994) Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods Enzymol, 105, pp. 429-435.
34. Lowry, OH, Rosebrough, AL, Farr, AL and Randal, RJ. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem, 193, pp. 265-275.
35. Napoli, J. (1996) Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clin Immunol Immunopathol, 80, pp. S52-S62.
36. Ross, AC. (1993) Cellular metabolism and activation of retinoids: Roles of cellular retinoid-binding proteins. FASEB J, 7, pp. 317-327.
37. Garrington, TP and Johnson, GL. (1999) Organization and regulation of mitogen activated protein kinase signaling pathways. Curr Opin Cell Biol, 11, pp. 211-218.
38. Rennefahrt, U., Janakiraman, M., Ollinger, R. and Troppmair, J. (2005) Stress kinase signaling in cancer: Fact or fiction?. Cancer Lett, 217, pp. 1-9.
39. Aggarwal, S., Kim, SW, Cheon, K., Tabassam, FH, Yoon, JH and Koo, JS. (2006) Nonclassical action of retinoic acid on the activation of the cAMP response element binding protein in normal human bronchial epithelial cells. Mol Biol Cell, 17, pp. 566-575.
40. Moreira, JC, Dal-Pizzol, F., Rocha, AB, Klamt, F., Ribeiro, NC, Ferreira, CJ and Bernard, EA. (2000) Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells. Braz J Med Biol Res, 33, pp. 287-293.
41. Buzzard, JJ, Wreford, NG and Morrison, JR. (2003) Thyroid hormone, retinoic acid, and testosterone suppress proliferation and induce markers of differentiation in cultured rat sertoli cells. Endocrinology, 144, pp. 3722-3731.
42. Liu, M., Lavarone, A. and Freedman, LP. (1996) Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J Biol Chem, 271, pp. 31723-31728.
43. Murata, M. and Kawanishi, S. (2000) Oxidative DNA damage by vitamin A and its derivative via superoxide generation. J Biol Chem, 275, pp. 2003-2008.
44. Allen, LH and Haskell, M. (2002) Estimating the potential for vitamin A toxicity in women and young children. J Nutr, 132, pp. 2907S-2919S.
45. Sporn, MB, Roberts, AB and Goodman, DS. (1994) The retinoids: Biology, chemistry and medicine, Raven Press, New York
46. Altucci, L., Leibowitz, MD, Ogilvie, KM, de Lera, AR and Gronemeyer, H. (2007) RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov, 6, pp. 793-810.
47. Kurlandsky, SB, Xiao, JH, Duell, EA, Voorhees, JJ and Fisher, GJ. (1994) Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes. J Biol Chem, 269, pp. 32821-32827.
48. Gronemeyer, H., Gustafsson, JA and Laudet, V. (2004) Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov, 3, pp. 950-964.
49. Hoyos, B., Imam, A., Chua, R., Swenson, C., Tong, G-X, Levi, E., Noy, N. and Hammerling, U. (2000) The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptor. J Exp Med, 192, pp. 835-845.
50. Nelson, KK and Melendez, JA. (2004) Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med, 15, pp. 768-784.