Differential regulation of the PIKK kinase family by Tel2

Cell Cycle

Volumn 7, Issue 23, 2008, Pages 3617-

  Boulton, Simon J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MEC1; PROTEIN TEL2; UNCLASSIFIED DRUG;

CELL CYCLE; CELL GROWTH; DNA DAMAGE; ENZYME ACTIVITY; ENZYME STABILITY; NONHUMAN; NOTE; PHENOTYPE; PROTEIN FUNCTION; YEAST;

EID: 57349163127     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.23.7430     Document Type: Note

References (5)

1. Ahmed S, Alpi A, Hengartner MO, Gartner A. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr Biol 2001; 11:1934-44.
2. Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev 2008; 22:854-9.
3. Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ. HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol 2007; 9:391-401.
4. Shikata M, Ishikawa F, Kanoh J. Tel2 is required for activation of the Mrc1-mediated replication checkpoint. J Biol Chem 2006; 282:5346-55.
5. Takai H, Wang RC, Takai KK, Yang H, de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell 2007; 131:1248-59.