Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 4, 2007, Pages 874-880

  Zimmermann, Anne ^a   Elema, Michiel Ringkjøbing ^b   Hansen, Tue ^b   Müllertz, Anette ^a   Hovgaard, Lars ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

Antisolvent precipitation; Evaporative light scattering detection (ELSD); Polymers; Poorly soluble drugs; Size exclusion chromatography (SEC); Surfactants

Indexed keywords

1' [4 [1 (4 FLUOROPHENYL) 1 H INDOL 3 YL] 1 BUTYL]SPIRO[ISOBENZOFURAN 1(3H) 4 PIPERIDINE]; ACETONITRILE; AMMONIUM FORMATE; DODECYL SULFATE SODIUM; EXCIPIENT; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LU 28 179; LUTROL; MACROGOL; POLIDOCANOL; POLOXAMER; POLYMER; UNCLASSIFIED DRUG; WATER;

ACCURACY; ACIDITY; ADSORPTION KINETICS; AQUEOUS SOLUTION; ARTICLE; CALIBRATION; CHROMATOPHORE; DRUG SOLUBILITY; DRUG STRUCTURE; EVAPORATION; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT ABSORPTION; LIGHT SCATTERING; LINEAR SYSTEM; MODEL; MOLECULAR WEIGHT; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SURFACE PROPERTY; WETTABILITY;

ADSORPTION; CALIBRATION; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; EXCIPIENTS; INDICATORS AND REAGENTS; LIGHT; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SOLVENTS; SURFACE PROPERTIES; ULTRAVIOLET RAYS;

EID: 34447623365     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.04.009     Document Type: Article

References (25)

1. Rasenack N., Hartenhauer H., and Muller B.W. Int. J. Pharm. 254 (2003) 137-145
2. Amidon G.A., Lennernäs H., Shah V.P., and Crison J.R. Pharm. Res. 12 (1995) 413-420
3. Rasenack N., Steckel H., and Muller B.W. Powder Technol. 143-144 (2004) 291-296
4. Majerik V., Charbit G., Badens E., Horvath G., Szokonya L., Bosc N., and Teillaud E. J. Supercrit. Fluids 40 (2007) 101-110
5. Sarkari M., Brown J., Chen X., Swinnea S., Williams I.I.I., and Johnston K.P. Int. J. Pharm. 243 (2002) 17-31
6. Kevelam J., Martinucci S., and Engberts J.B.F.N. Langmuir 15 (1999) 4989-5001
7. Zhu L., Seburg R.A., and Tsai E.W. J. Pharm. Biomed. Anal. 40 (2006) 1089-1096
8. Erlandsson B., Wittgren B., and Brinkmalm G. J. Pharm. Biomed. Anal. 31 (2003) 845-858
9. Whelan M.R., Ford J.L., and Powell M.W. J. Pharm. Biomed. Anal. 30 (2002) 1355-1359
10. Faisant N., Akiki J., Siepmann F., Benoit J.P., and Siepmann J. Int. J. Pharm. 314 (2006) 189-197
11. Husmann M., Schenderlein S., Luck M., Lindner H., and Kleinebudde P. Int. J. Pharm. 242 (2002) 277-280
12. Park H.S., and Rhee C.K. J. Chromatogr. A 1046 (2004) 289-291
13. Bunger H., and Pison U. J. Chromatogr. B 672 (1995) 25-31
14. Ravisankar S., Vasudevan M., Gandhimathi M., and Suresh B. Talanta 46 (1998) 1577-1581
15. Nair L.M., Konkel J., Thomas M., and Koberda M. J. Pharm. Biomed. Anal. 41 (2006) 725-730
16. Forget R., and Spagnoli S. J. Pharm. Biomed. Anal. 41 (2006) 1051-1055
17. Agueros M., Campanero M.A., and lrache J.M. J. Pharm. Biomed. Anal. 39 (2005) 495-502
18. Koropchak J.A., Heenan C.L., and Allen L.B. J. Chromatogr. A 736 (1996) 11-19
19. Clarot I., Chaimbault P., Hasdenteufel F., Netter P., and Nicolas A. J. Chromatogr. A 1031 (2004) 281-287
20. Beilmann B., Langguth P., Hausler H., and Grass P. J. Chromatogr. A 1107 (2006) 204-207
21. Megoulas N.C., and Koupparis M.A. J. Chromatogr. A 1057 (2004) 125-131
22. Porter R.S., and Chen T.K. J. Chromatogr. A 732 (1996) 399-402
23. Trathnigg B., and Kollroser M. J. Chromatogr. A 768 (1997) 223-238
24. Kibbey T.C.G., Yavaraski T.P., and Hayes K.F. J. Chromatogr. A 752 (1996) 155-165
25. Zhou J.Y., Chaminade P., Gaudin K., Prognon P., Baillet A., and Ferrier D. J. Chromatogr. A 859 (1999) 99-105