Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-α]quinoline-4-carboxylic acid derivatives

Medicinal Chemistry

Volumn 4, Issue 5, 2008, Pages 482-491

  Dinakaran, Murugesan ^a   Senthilkumar, Palaniappan ^a   Yogeeswari, Perumal ^a   China, Arnab ^b   Nagaraja, Valakunja ^b   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Antimycobacterial activity; Antitubercular activity; Thiazoloquinolone; Tuberculosis

Indexed keywords

2,5 DIHYDRO 8 (2,6 DIMETHYLMORPHOLINO) 7 NITRO 5 OXO 1H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; 5H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID DERIVATIVE; 8 (1,4 DIOXA 7 AZASPIROL[4.5]DEC 8 YL) 7 FLUORO 1,2 DIHYDRO 5 OXO 5H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; 8 (2 CARBOXY 5,6 DIHYDROIMIDAZOL[1,2 A]PYRAZIN 7(8H) YL) 7 FLUORO 2,5 DIHYDRO 5 OXO 1H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; 8 [1 (TERT BUTYLCARBAMOYL) 3,4 DIHYDROISOQUINOLIN 2 (1H) YL] 2,5 DIHYDRO 7 NITRO 5 OXO 1H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; 8 [4 (6 CHLORO 1,2 DIHYDRO 2 OXOBENZO[D]IMIDAZOL 3 YL)PIPERIDIN 1 YL] 2,5 DIHYDRO 7 FLUORO 5 OXO 1H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; 8 [6 [[(1,1 DIMETHYLETHOXY)CARBONYL]AMINO] 3 AZABICYCLO[3.1.0]HEX 3 YL] 7 NITRO 1,2 DIHYDRO 5 OXO 5H THIAZOLO[3,2 A]QUINOLINE 4 CARBOXYLIC ACID; ANTIBIOTIC AGENT; ANTIMYCOBACTERIAL AGENT; GATIFLOXACIN; GYRASE INHIBITOR; ISONIAZID; LOMEFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DNA SUPERCOILING; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL INFECTION; GROWTH INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MULTIDRUG RESISTANCE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DERMATITIS, PHOTOTOXIC; DNA GYRASE; LUNG; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; QUINOLINES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 57349143932     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608785700225     Document Type: Article

References (20)

1. Blumberg, H.M.; Leonard, J.; Jasmer, R.M. J. Am. Med. Assoc., 2005, 293, 2776.
2. DeAngelis, C.D.; Flanagin, A. J. Am. Med. Assoc., 2005, 293, 2793.
3. Hampton, T. J. Am. Med. Assoc., 2005, 293, 2705.
4. Nettleman, M.D. J. Am. Med. Assoc., 2005, 293, 2788.
5. Janin, Y.L. Bioorg. Med. Chem., 2007, 15, 2479.
6. Sato, K.; Tomioka, H.; Sano, C.; Shimizu, T.; Sano, K.; Ogasawara, K.; Cai, S.; Kamei, T. J. Antimicrob. Chemother., 2003, 52, 199.
7. Maxwell, A. Trends Microbiol., 1997, 5, 102.
8. Alangaden, G.J.; Lerner, S.A. Clin. Infect. Dis., 1997, 25, 1213.
9. Sriram, D.; Aubry, A.; Yogeeswari, P.; Fisher, L.M. Bioorg. Med. Chem. Lett., 2006, 16, 2982.
10. Sriram, D.; Yogeeswari, P.; Basha, J.S.; Radha, D.R.; Nagaraja, V. Bioorg. Med. Chem., 2005, 13, 5774.
11. Kondo, H.; Taguchi, M.; Inoue, Y.; Sakamoto, F.; Tsukamoto, G. J. Med. Chem., 1990, 33, 2012.
12. National Committee for Clinical Laboratory Standards. Antimycobacterial susceptibility testing for Mycobacterium tuberculosis. Proposed standard M24-T. National Committee for Clinical Laboratory Standards, Villanova, Pa., 1995.
13. Gundersen, L.L.; Nissen-Meyer, J.; Spilsberg, B. J. Med. Chem., 2002, 45, 1383.
14. Levine, C.H.; Hiasa, A.; Marians, K.J. Biochem. Biophys. Acta, 1998, 14, 29.
15. Manjunatha, U.H.; Madhusudan, K.; Sandhya, S.; Visweswariah, S.S.; Nagaraja, V. Curr. Sci., 2000, 79, 968.
16. Ferguson, J.; Walker, E.M.; Johnson, B.E. Br. J. Dermat., 1989, 120, 291.
17. Domagala, J.M. J. Antimicrob. Chemother., 1994, 33, 685.
18. Takayama, S.; Hirohashi, M.; Kato, M.; Shimada, H.J. Toxicol. Environ. Health, 1995, 45, 1.
19. Mayne, J.T.; Johnson, N.J.; Kluwe, W.M.; Lencoski, D.L.; Polzer, R.J. J. Antimicrob. Chemother., 1997, 39, 67.
20. Manjunatha, U.H.; Dalal, M.; Chatterji, M.; Radha, D.R.; Visweswariah, S.S.; Nagaraja, V. Nucleic Acids Res., 2002, 30, 2144.