Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion

Journal of Toxicological Sciences

Volumn 33, Issue 5, 2008, Pages 549-553

  Waring, W Stephen ^a   Benhalim, Suzanne ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Acetaminophen; Codeine; Drug concentration; Opioid; Overdose; Poisoning

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ALCOHOL; ANTIDEPRESSANT AGENT; BENZODIAZEPINE; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG ALCOHOL INTERACTION; DRUG BLOOD LEVEL; DRUG OVERDOSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; TOXICOKINETICS;

EID: 57349139449     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.33.549     Document Type: Article

References (17)

1. Adams, B.K., Mann, M.D., Aboo, A., Isaacs, S. and Evans, A. (2004): Prolonged gastric emptying half-time and gastric hypomotility after drug overdose. Am. J. Emerg. Med., 22, 548-554.
2. Addolorato, G., Montalto, M., Capristo, E., Certo, M., Fedeli, G., Gentiloni, N., Stefanini, G.F. and Gasbarrini, G. (1997): Influence of alcohol on gastrointestinal motility: lactulose breath hydrogen testing in orocecal transit time in chronic alcoholics, social drinkers and teetotaler subjects. Hepatogastroenterology, 44, 1076-1081.
3. Bateman, D.N. and Good, A.M. (2006): Five years of poisons information on the internet: the UK experience of TOXBASE. Emerg. Med. J., 23, 614-617.
4. Brok, J., Buckley, N. and Gluud, C. (2006): Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst. Rev., 2, CD003328.
5. Buckley, N. and Eddleston, M. (2005): Paracetamol (acetaminophen) poisoning. Clin. Evid., 14, 1738-1744.
6. Camidge, D.R., Wood, R.J. and Bateman, D.N. (2003): The epidemiology of self-poisoning in the UK. Br. J. Clin. Pharmacol., 56, 613-619.
7. Daly, F.F., Fountain, J.S., Murray, L., Graudins, A. and Buckley, N.A. (2008): Guidelines for the management of paracetamol poisoning in Australia and New Zealand: explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Med. J. Aust., 188, 296-302.
8. Halcomb, S.E., Sivilotti, M.L., Goklaney, A. and Mullins, M.E. (2005): Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad. Emerg. Med., 12, 169-172.
9. Müller, F.O., van Achterbergh, S.M. and Hundt, H.K. (1983): Paracetamol overdose: protective effect of concomitantly ingested antimuscarinic drugs and codeine. Hum. Toxicol., 2, 473-477.
10. Myers, R.P., Li, B. and Shaheen, A.A. (2007): Emergency department visits for acetaminophen overdose: a Canadian population-based epidemiologic study (1997-2002). CJEM, 9, 267-274.
11. Nimmo, W.S., Todd, J.G. and Vogel, J. (1986): Effect of meptazinol on drug absorption and gastric emptying. Eur. J. Anaesthesiol., 3, 295-298.
12. Schmidt, L.E. and Dalhoff, K. (2002): Concomitant overdosing of other drugs in patients with paracetamol poisoning. Br. J. Clin. Pharmacol., 53, 535-541.
13. Thanacoody, H.K., Good, A.M., Waring, W.S. and Bateman, D.N. (2008): Survey of cases of paracetamol overdose in the UK referred to National Poisons Information Service (NPIS) consultants. Emerg. Med. J., 25, 140-143.
14. Waring, W.S., Stephen, A.F., Malkowska, A.M. and Robinson, O.D. (2008a): Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose. Acad. Emerg. Med., 15, 54-58.
15. Waring, W.S., Stephen, A.F., Robinson, O.D., Dow, M.A. and Pettie, J.M. (2008b): Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin. Toxicol., 46, 496-500.
16. Waring, W.S., Robinson, O.D., Stephen, A.F., Dow, M.A. and Pettie, J.M. (2008c): Does the patient history predict hepatotoxicity after acute paracetamol overdose? QJM, 101, 121-125.
17. Zou, G. and Klar, N. (2005): A non-iterative confidence interval estimating procedure for the intraclass kappa statistic with multinomial outcomes. Biom. J., 47, 682-690.