Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose

Clinical Toxicology

Volumn 46, Issue 6, 2008, Pages 496-500

  Waring, W Stephen ^a   Stephen, Alexandra F ^a   Robinson, Oliver D ^a   Dow, Margaret A ^a   Pettie, Janice M ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Acetaminophen; Adverse drug reaction; Overdose; Poisoning; Toxicity

Indexed keywords

ACETYLCYSTEINE; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; CARBAMAZEPINE; CORTICOSTEROID; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; RIFAMPICIN; SALBUTAMOL;

ADULT; ANAPHYLAXIS; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INTOXICATION; DRUG OVERDOSE; DRUG WITHDRAWAL; EMERGENCY WARD; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INCIDENCE; INJECTION SITE REACTION; LIVER DISEASE; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MALNUTRITION;

ACETAMINOPHEN; ACETYLCYSTEINE; ADULT; ANALGESICS, NON-NARCOTIC; ANAPHYLAXIS; ANTIDOTES; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; OVERDOSE; PROSPECTIVE STUDIES;

EID: 46249097981     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701864760     Document Type: Article

References (34)

1. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998; 31:710-715.
2. Schmidt LE, Dalhoff K. Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. Br J Clin Pharmacol 2001; 51:87-91.
3. Lynch RM, Robertson R. Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study. Accid Emerg Nurs 2004; 12:10-15.
4. Knudsen TT, Thorsen S, Jensen SA, Dalhoff K, Schmidt LE, Becker U, Bendtsen F. Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects. Gut 2005; 54:515-521.
5. Butera R, Georgatos J, Arrigoni S, Lonati D, Petrolini V, Locatelli C, Manzo L. Adverse reactions to intravenous acetylcysteine: effects of reducing the infusion rate of the loading dose. Clin Toxicol 2005; 43:437-438.
6. Lieberman P, Kemp SF, Oppenheimer J, Lang DM, Bernstein L, Nicklas RA. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol 2005; 115:S483-523.
7. Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, Brown SG, Camargo CA Jr, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD Jr, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW. Second symposium on the definition and management of anaphylaxis: summary reportdSecond National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006; 117:391-397.
8. Gheshlagi F, Izadi-Mood N, Amini R, Montazeri G. Prevalence of hypersensitivity reactions to intravenous n-acetylcysteine in acetaminophen poisoned patients. Clin Toxicol 2005; 43:514-515.
9. Smilkstein MJ, Bronstein AC, Linden C, Augenstein WL, Kulig KW, Rumack BH. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991; 20:1058-1063.
10. Mant TG, Tempowski JH, Volans GN, Talbot JC. Adverse reactions to acetylcysteine and effects of overdose. BMJ 1984; 289:217-219.
11. Prescott LF, Donovan JW, Jarvie DR, Proudfoot AT. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37:501-506.
12. Bateman DN, Woodhouse KW, Rawlins MD. Adverse reactions to N-acetylcysteine. Lancet 1984; 2:228.
13. Kerr F, Dawson A, Whyte IM, Buckley N, Murray L, Graudins A, Chan B, Trudinger B. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med 2005; 45:402-408.
14. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994; 54:543-547.
15. Sunman W, Hughes AD, Sever PS. Anaphylactoid response to intravenous acetylcysteine. Lancet 1992; 339:1231-1232.
16. Waring WS, Pettie JM, Dow MA, Bateman DN. Paracetamol appears to protect against N-acetylcysteine-induced anaphylactoid reactions. Clin Toxicol 2006; 44:441-442.
17. Newton PJ, Thomas SHL. Anaphylactoid reactions to intravenous acetylcysteine, frequency, risk factors and outcome. Clin Toxicol 2006; 44:432.
18. Bateman DN, Good AM. Five years of poisons information on the internet: the UK experience of TOXBASE. Emerg Med J 2006; 23:614-617.
19. Buckley N, Eddleston M. Paracetamol (acetaminophen) poisoning. Clin Evid 2005; 14:1738-1744.
20. Report of a Working Party of the Royal College of Physicians. Alcohol- can the NHS afford it? Recommendations for a coherent alcohol strategy for hospitals. Royal College of Physicians of London, 2001.
21. Rumack BH, Peterson RC, Koch GG, Amara IA. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981; 141:380-385.
22. Zou G, Klar N. A non-iterative confidence interval estimating procedure for the intraclass kappa statistic with multinomial outcomes. Biom J 2005; 47:682-690.
23. Sprong RC, Winkelhuyzen-Janssen AM, Aarsman CJ, van Oirschot JF, van der Bruggen T, van Asbeck BS. Low-dose N-acetylcysteine protects rats against endotoxin-mediated oxidative stress, but high-dose increases mortality. Am J Respir Crit Care Med 1998; 157:1283-1293.
24. Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther 2005; 12:46-55.
25. Nossaman BD, Baber SR, Nazim MM, Waldron PR, Hyman AL, Kadowitz PJ. Acetaminophen, Phenacetin and Dipyrone Do Not Modulate Pressor Responses to Arachidonic Acid or to Pressor Agents. Pharmacology 2007; 80:249-260.
26. Robak J, Wieckowski A, Gryglewski R. The effect of 4-acetamidophenol on prostaglandin synthetase activity in bovine and ram seminal vesicle microsomes. Biochem Pharmacol 1978; 27:393-396.
27. Mukherjee TK, Mishra AK, Mukhopadhyay S, Hoidal JR. High concentration of antioxidants N-acetylcysteine and mitoquinone-Q induces intercellular adhesion molecule 1 and oxidative stress by increasing intracellular glutathione. J Immunol 2007; 178:1835-1844.
28. Lou H, Kaplowitz N. Glutathione depletion down-regulates tumor necrosis factor (TNF) alpha -induced NF-kappa B activity via Ikappa B Kinase (IKK)-dependent and -independent mechanisms. J Biol Chem. 2007 Aug 9 [Epub ahead of print].
29. Dimova S, Hoet PH, Dinsdale D, Nemery B. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Int J Biochem Cell Biol 2005; 37:1727-1737.
30. Szaszi K, Jones JJ, Nathens AB, Lo AY, Marsden PA, Kapus A, Rotstein OD. Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis. Free Radic Biol Med 2005; 38:1333-43.
31. Sakhi AK, Blomhoff R, Gundersen TE. Simultaneous and trace determination of reduced and oxidized glutathione in minute plasma samples using dual mode fluorescence detection and column switching high performance liquid chromatography. J Chromatogr A 2007; 1142:178-184.
32. Sakaguchi S, Furusawa S. Oxidative stress and septic shock: metabolic aspects of oxygen-derived free radicals generated in the liver during endotoxemia. FEMS Immunol Med Microbiol 2006; 47:167-177.
33. Rork TH, Hadzimichalis NM, Kappil MA, Merrill GF. Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. J Mol Cell Cardiol 2006; 40:553-561.
34. Shaffer JE, Cagen LM, Malik KU. Attenuation by acetaminophen or arachidonic acid-induced coronary vasodilation and output of prostaglandins in the isolated rat heart. Eur J Pharmacol 1981; 72:57-61.