Cerebrospinal fluid of patients administered moxifloxacin modulates the secretion of cytokines from human monocytes

Diagnostic Microbiology and Infectious Disease

Volumn 63, Issue 1, 2009, Pages 62-69

  Giamarellos Bourboulis, Evangelos J ^a   E Douzinas, Emmanouel ^a   Tsaganos, Thomas ^a   Pagoulatou, Alexandra ^b   Livaditi, Olga ^a   Vafiadou, Marianthi ^b   Kanellakopoulou, Kyriaki ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b SISMANOGLIO HOSPITAL   (Greece)

Author keywords

Cytokines; Immunomodulation; Monocytes; Moxifloxacin; Streptococcus pneumoniae

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MOXIFLOXACIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL SECRETION; CEREBROSPINAL FLUID ANALYSIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOMODULATION; MENINGITIS; MONOCYTE; PRIORITY JOURNAL; SINGLE DRUG DOSE; STREPTOCOCCUS PNEUMONIAE;

ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; CEREBROSPINAL FLUID; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNIZATION; IMMUNOLOGIC FACTORS; LIPOPOLYSACCHARIDES; MONOCYTES; PROSPECTIVE STUDIES; QUINOLINES; SERUM; STREPTOCOCCUS PNEUMONIAE; U937 CELLS;

EID: 57349136810     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2008.09.003     Document Type: Article

References (16)

1. Araujo F.G., Slifer T.L., and Remington J.S. Effect of moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide. Clin. Microbiol. Infect. 8 (2002) 26-30
2. Blau H., Klein K., Shalit I., Halperin D., and Fabian I. Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2. JNK, and NF-κB activation in a cystic fibrosis epithelial cell line. Am. J. Physiol. Lung. Cell. Mol. Physiol. 292 (2007) L343-L352
3. Choi J.H., Song M.J., Kim S.H., Choi S.M., Lee D.G., Yoo J.H., and Shin W.S. Effect of moxifloxacin on production of proinflammatory cytokines from human peripheral blood mononuclear cells. Antimicrob. Agents Chemother. 47 (2003) 3704-3707
4. Cook E.B., Stahl J.L., Lowe L., Chen R., Morgan E., Wilson J., Varro R., Chan A., Graziano F.M., and Barney N.P. Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics. J. Immunol. Methods 254 (2001) 109-118
5. Dalhoff A. Immunomodulatory activities of fluoroquinolones. Infection 33 Suppl. 2 (2005) 55-70
6. Drenth J.P.H., and van Der Meer J.W.M. The inflammasome-a linebacker of innate defense. N. Engl. J. Med. 355 (2006) 730-732
7. Giamarellos-Bourboulis E.J. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int. J. Antimicrob. Agents 31 (2008) 12-20
8. Kanellakopoulou K., Pagoulatou A., Stroumpoulis K., Vafiadou M., Kranidiotii H., Giamarellou H., and Giamarellos-Bourboulis E.J. Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect. J. Antimicrob. Chemother. 61 (2008) 1328-1331
9. Ostergaard C., Sorensen T.K., Knudsen J.D., and Frimodt-Møller N. Evaluation of moxifloxacin, a new 8-methoxyquinolone, for treatment of meningitis caused by a penicillin-resistant pneumococcus in rabbits. Antimicrob. Agents Chemother. 42 (1998) 1706-1712
10. Rodriguez-Cerrato V., McCoig C.C., Michelow I.C., Ghaffar F., Jafri H.S., Hardy R.D., Patel C., Olsen K., and McCracken Jr. G.H. Pharmacodynamics and bactericidal activity of moxifloxacin in experimental Escherichia coli meningitis. Antimicrob. Agents Chemother. 45 (2001) 3092-3097
11. Schmidt H., Dalhoff A., Stuertz K., Trostdorf F., Chen V., Schneider O., Kohlsdofer C., Brück W., and Nau R. Moxifloxacin in the therapy of experimental pneumococcal meningitis. Antimicrob. Agents Chemother. 42 (1998) 1397-1401
12. Shalit I., Horev-Azaria L., Fabian I., Blau H., Kariv N., Shechtman I., Alteraz H., and Kletter Y. Immunomodulatory and protective effects of moxifloxacin against Candida albicans-induced bronchopneumonia in mice injected with cyclophosphamide. Antimicrob. Agents Chemother. 46 (2002) 2442-2449
13. Shalit I., Halperin D., Haite D., Levitov A., Romano J., Osherov N., and Fabian I. Anti-inflammatory effects of moxifloxacin on IL-8, IL-1β and TNFα secretion and NFκB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus. J. Antimicrob. Chemother. 57 (2006) 230-235
14. Shoma S., Tsuchiya K., Kawamura I., Nomura T., Hara H., Uchiyama R., Daim S., and Mitsuyama M. Critical involvement of pneumolysin in production of IL-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation. Infect. Immun. 76 (2008) 1547-1557
15. Weiss T., Shalit I., Blau H., Werber S., Halperin D., Levitor A., and Fabian I. Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-κB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines. Antimicrob. Agents Chemother. 48 (2004) 1974-1982
16. Zielonka T.M., Demkow U., Białas B., Filewska M., Zycinska K., Radzikowska E., Szopiński J., and Skopińska-Rózewska E. Modulatory effect of sera from sarcoidosis patients on mononuclear cell-induced angiogenesis. J. Physiol. Pharmacol. 58 Suppl. 5 (2007) 753-766